RT Journal Article
SR Electronic
T1 Association study of Toll-like receptor 5 (TLR5) and Toll-like receptor 9 (TLR9) polymorphisms in systemic lupus erythematosus.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1708
OP 1711
VO 34
IS 8
A1 F Yesim K Demirci
A1 Susan Manzi
A1 Rosalind Ramsey-Goldman
A1 Margaret Kenney
A1 Penny S Shaw
A1 Charmayne M Dunlop-Thomas
A1 Amy H Kao
A1 Elisa Y Rhew
A1 Franklin Bontempo
A1 Candace Kammerer
A1 M Ilyas Kamboh
YR 2007
UL http://www.jrheum.org/content/34/8/1708.abstract
AB OBJECTIVE: Toll-like receptors (TLR) play an important role in both adaptive and innate immunity. Variations in TLR genes have been shown to be associated with various infectious and inflammatory diseases. We investigated the association of TLR5 (Arg392Stop, rs5744168) and TLR9 (-1237T-->C, rs5743836) single nucleotide polymorphisms (SNP) with systemic lupus erythematosus (SLE) in Caucasian American subjects. METHODS: We performed a case-control association study and genotyped 409 Caucasian women with SLE and 509 Caucasian healthy female controls using TaqMan allelic discrimination (rs5744168) or polymerase chain reaction-restriction fragment length polymorphism analysis (rs5743836). RESULTS: None of the 2 TLR SNP showed a statistically significant association with SLE risk in our cohort. CONCLUSION: Our results do not indicate a major influence of these putative functional TLR SNP on the susceptibility to (or protection from) SLE.