RT Journal Article
SR Electronic
T1 Etanercept-related extensive pulmonary nodulosis in a patient with rheumatoid arthritis.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1590
OP 1592
VO 34
IS 7
A1 Annelies van Ede
A1 Alfons den Broeder
A1 Michiel Wagenaar
A1 Piet van Riel
A1 Marjonne C W Creemers
YR 2007
UL http://www.jrheum.org/content/34/7/1590.abstract
AB OBJECTIVE: Although nodulosis is a common extraarticular manifestation of rheumatoid arthritis, accelerated pulmonary nodulosis is a rare event. The etiology of rheumatoid nodules is still unknown. Nodulosis is not necessarily associated with active joint inflammation, suggesting different pathogenic mechanisms for nodule formation and synovial tissue inflammation. We describe a patient with extensive pulmonary nodulosis, probably related to etanercept treatment. Our case emphasizes the need for careful monitoring for adverse events during treatment with biologicals, especially since the differential diagnosis often includes a broad spectrum of diseases.