PT  - JOURNAL ARTICLE
AU  - MASSOUD DAHESHIA
AU  - JIAN Q. YAO
TI  - The Interleukin 1β Pathway in the Pathogenesis of Osteoarthritis
AID  - 10.3899/jrheum.080346
DP  - 2008 Dec 01
TA  - The Journal of Rheumatology
PG  - 2306--2312
VI  - 35
IP  - 12
4099  - http://www.jrheum.org/content/35/12/2306.short
4100  - http://www.jrheum.org/content/35/12/2306.full
SO  - J Rheumatol2008 Dec 01; 35
AB  - Osteoarthritis (OA) is a major disabling disease and is ranked as a major cause of chronic pain in adults. The pathology of the illness is characterized by a loss of articular cartilage leading to narrowing of joint space, increased joint friction, potential structural remodeling, persistent pain, and functional impairment. The proinflammatory cytokine interleukin 1β (IL-1β) has several chemical and bioactive characteristics allowing this catabolic protein to be involved in initiation and progression of OA. We review the current understanding of the pathogenesis of OA, and how upregulation of IL-1β initiates a cascade of intracellular events that can culminate in activation…