TY - JOUR T1 - Hepatotoxicity Associated with Etanercept in Psoriatic Arthritis JF - The Journal of Rheumatology JO - J Rheumatol SP - 2286 LP - 2288 DO - 10.3899/jrheum.080521 VL - 35 IS - 11 AU - ALISON M. LEAK AU - BLANCA RINCON-AZNAR Y1 - 2008/11/01 UR - http://www.jrheum.org/content/35/11/2286.2.abstract N2 - To the Editor: We were interested to read the recent case report on granulomatous hepatitis associated with etanercept therapy in a patient with rheumatoid arthritis (RA)1. We have also experienced hepatotoxicity with etanercept, although in a patient with psoriatic arthritis (PsA). A 50-year-old woman had a 20-year history of pustular psoriasis and PsA including arthritis mutilans. Psoriasis had been treated with combinations of topical and systemic drugs, including retinoids. Various nonsteroidal antiinflammatory drugs and disease-modifying antirheumatic drugs (DMARD) had been poorly tolerated or not effective. Episodes of toxicity included suspected allergic reactions (ibuprofen), raised transaminases (methotrexate), renal impairment (cyclosporine), and ... ER -