PT  - JOURNAL ARTICLE
AU  - HYOUNG DOO SHIN
AU  - IL KIM
AU  - CHAN-BUM CHOI
AU  - SOO OK LEE
AU  - HYE WON LEE
AU  - SANG-CHEOL BAE
TI  - Different Genetic Effects of Interferon Regulatory Factor 5 (<em>IRF5</em>) Polymorphisms on Systemic Lupus Erythematosus in a Korean Population
AID  - 10.3899/jrheum.080124
DP  - 2008 Nov 01
TA  - The Journal of Rheumatology
PG  - 2148--2151
VI  - 35
IP  - 11
4099  - http://www.jrheum.org/content/35/11/2148.short
4100  - http://www.jrheum.org/content/35/11/2148.full
SO  - J Rheumatol2008 Nov 01; 35
AB  - Objective In an effort to replicate additional associations of interferon regulatory factor 5 (IRF5) polymorphisms with systemic lupus erythematosus (SLE) in an Asian population, we examined those genetic effects in a Korean SLE cohort. Methods Each IRF5 polymorphism was genotyped in 1565 subjects using the TaqMan method and examined to determine whether it could explain the association with SLE. Results Three single-nucleotide polymorphisms (IRF5-15-1, rs2070197, and rs10488631), which showed strong and/or independent association in Caucasian populations, were not polymorphic in our Korean population. Association analysis revealed different genetic effects in Koreans compared with Caucasian populations. In addition, conditional analysis suggested independent genetic effects of 3 variant groups in the Korean population. Conclusion We demonstrate different genetic effects of IRF5 polymorphisms on the risk of SLE according to ethnicity.