RT Journal Article
SR Electronic
T1 Differential Response of the Rheumatoid Factor and Anticitrullinated Protein Antibodies During Adalimumab Treatment in Patients with Rheumatoid Arthritis
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1972
OP 1977
VO 35
IS 10
A1 WOUTER H. BOS
A1 GEERTJE M. BARTELDS
A1 GERRIT JAN WOLBINK
A1 MARGRET H.M.T. de KONING
A1 ROB J. van de STADT
A1 DIRKJAN van SCHAARDENBURG
A1 BEN A.C. DIJKMANS
A1 MICHAEL T. NURMOHAMED
YR 2008
UL http://www.jrheum.org/content/35/10/1972.abstract
AB Objective To investigate the effect of anti-tumor necrosis factor (TNF) treatment on rheumatoid factor (IgM-RF) and anticitrullinated protein antibodies (ACPA) and its association with treatment response and acute-phase reactants. Methods In a cohort of 188 consecutive patients with rheumatoid arthritis (RA) treated with adali-mumab, baseline IgM-RF and ACPA were determined by ELISA, and compared to levels after 28 weeks of treatment. ACPA were measured as antibodies to cyclic citrullinated peptide (anti-CCP). The relative change of antibody levels was correlated to the European League Against Rheumatism response criteria and to the change in acute-phase reactants [erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)]. Results The median decline in IgM-RF levels was greater than the decline in ACPA levels (31% vs 8%; p < 0.001). The decrease in antibody levels was greater in the group of good responders than in the group of nonresponders [43% vs 7% for IgM-RF (p < 0.0001) and 16 vs –4% for ACPA (p = 0.03)]. Seventeen percent of IgM-RF-positive patients at baseline turned negative at 28 weeks; this qualitative effect was not observed for ACPA. Further, the decline in IgM-RF, but not ACPA, was associated with a decrease in CRP and ESR (p = 0.004 and p = 0.006, respectively). Conclusion TNF treatment directly influences IgM-RF and ACPA levels, but in those responding to treatment only. The effect on IgM-RF levels and positivity status is greater than on ACPA levels and is associated with the decline in markers of inflammation. These results further emphasize the differential role these autoantibodies may play in RA; IgM-RF as marker of inflammatory activity, and ACPA as qualitatively stable hallmark of RA.