TY - JOUR T1 - Synovial macrophages as a biomarker of response to therapeutic intervention in rheumatoid arthritis: standardization and consistency across centers. JF - The Journal of Rheumatology JO - J Rheumatol SP - 620 LP - 622 VL - 34 IS - 3 AU - Barry Bresnihan AU - Danielle M Gerlag AU - Terence Rooney AU - Tom J M Smeets AU - Carla A Wijbrandts AU - David Boyle AU - Oliver Fitzgerald AU - Bruce W Kirkham AU - Iain B McInnes AU - Malcolm Smith AU - Ann-Kristin Ulfgren AU - Douglas J Veale AU - Paul P Tak Y1 - 2007/03/01 UR - http://www.jrheum.org/content/34/3/620.abstract N2 - Successive studies from one academic center (Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands) have consistently suggested that synovial tissue expression of sublining macrophages may be a biomarker of clinical response to therapeutic intervention in rheumatoid arthritis (RA) clinical trials. A proof-of-concept, randomized clinical trial was completed at a second academic center (St. Vincent's University Hospital, Dublin, Ireland), and the relationship between the change in disease activity and the change in sublining macrophages in distinct treatment cohorts was determined. The preliminary findings were not conclusive, but appeared to support a role for sublining CD68+ macrophages as a biomarker of clinical response to therapeutic intervention in cohorts of patients with RA. ER -