RT Journal Article
SR Electronic
T1 Synovial macrophages as a biomarker of response to therapeutic intervention in rheumatoid arthritis: standardization and consistency across centers.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 620
OP 622
VO 34
IS 3
A1 Barry Bresnihan
A1 Danielle M Gerlag
A1 Terence Rooney
A1 Tom J M Smeets
A1 Carla A Wijbrandts
A1 David Boyle
A1 Oliver Fitzgerald
A1 Bruce W Kirkham
A1 Iain B McInnes
A1 Malcolm Smith
A1 Ann-Kristin Ulfgren
A1 Douglas J Veale
A1 Paul P Tak
YR 2007
UL http://www.jrheum.org/content/34/3/620.abstract
AB Successive studies from one academic center (Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands) have consistently suggested that synovial tissue expression of sublining macrophages may be a biomarker of clinical response to therapeutic intervention in rheumatoid arthritis (RA) clinical trials. A proof-of-concept, randomized clinical trial was completed at a second academic center (St. Vincent's University Hospital, Dublin, Ireland), and the relationship between the change in disease activity and the change in sublining macrophages in distinct treatment cohorts was determined. The preliminary findings were not conclusive, but appeared to support a role for sublining CD68+ macrophages as a biomarker of clinical response to therapeutic intervention in cohorts of patients with RA.