PT  - JOURNAL ARTICLE
AU  - Barry Bresnihan
AU  - Danielle M Gerlag
AU  - Terence Rooney
AU  - Tom J M Smeets
AU  - Carla A Wijbrandts
AU  - David Boyle
AU  - Oliver Fitzgerald
AU  - Bruce W Kirkham
AU  - Iain B McInnes
AU  - Malcolm Smith
AU  - Ann-Kristin Ulfgren
AU  - Douglas J Veale
AU  - Paul P Tak
TI  - Synovial macrophages as a biomarker of response to therapeutic intervention in rheumatoid arthritis: standardization and consistency across centers.
DP  - 2007 Mar 01
TA  - The Journal of Rheumatology
PG  - 620--622
VI  - 34
IP  - 3
4099  - http://www.jrheum.org/content/34/3/620.short
4100  - http://www.jrheum.org/content/34/3/620.full
SO  - J Rheumatol2007 Mar 01; 34
AB  - Successive studies from one academic center (Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands) have consistently suggested that synovial tissue expression of sublining macrophages may be a biomarker of clinical response to therapeutic intervention in rheumatoid arthritis (RA) clinical trials. A proof-of-concept, randomized clinical trial was completed at a second academic center (St. Vincent's University Hospital, Dublin, Ireland), and the relationship between the change in disease activity and the change in sublining macrophages in distinct treatment cohorts was determined. The preliminary findings were not conclusive, but appeared to support a role for sublining CD68+ macrophages as a biomarker of clinical response to therapeutic intervention in cohorts of patients with RA.