RT Journal Article SR Electronic T1 Association of ACE gene polymorphism with genetic susceptibility to systemic lupus erythematosus in a Chinese population: a family-based association study. JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 2408 OP 2411 VO 34 IS 12 A1 Jianhua Xu A1 Yong Wang A1 Faming Pan A1 Jim Stankovich A1 Dongqing Ye A1 Li Lian A1 Kechun Zhang A1 Changhai Ding YR 2007 UL http://www.jrheum.org/content/34/12/2408.abstract AB OBJECTIVE: Family-based association analysis was performed to investigate whether the angiotensin-converting enzyme (ACE)-G261T and ACE-A592G polymorphisms are risk factors for systemic lupus erythematosus (SLE) in a Chinese population. METHODS: A total of 119 patients with SLE from 95 nuclear families, aged from 14 to 78 years, who met the American College of Rheumatology 1997 criteria, were recruited, as were 316 family members of these patients. A family-based association study was used to explore the association between ACE gene polymorphisms (ACE-G261T and ACE-A592G) and SLE. The ACE gene polymorphisms were genotyped with restriction fragment length polymorphism-polymerase chain reaction. RESULTS: Using family-based association tests, the T allele of the ACE-G261T single-nucleotide polymorphism (SNP) was significantly associated with genetic susceptibility to SLE in an additive model (Z = 2.877, p = 0.004), a dominant model (Z = 2.557, p = 0.011), and a recessive model (Z = 2.202, p = 0.028). No association between the ACE-A592G SNP and SLE susceptibility was determined. CONCLUSION: The T allele of the ACE-G261T SNP was associated with SLE in this Chinese population.