@article {Mastana1984, author = {Sarabjit Mastana and Ashley Gilmour and Anant Ghelani and Hannah Smith and Ash Samanta}, title = {Association of PTPN22 with rheumatoid arthritis among South Asians in the UK.}, volume = {34}, number = {10}, pages = {1984--1986}, year = {2007}, publisher = {The Journal of Rheumatology}, abstract = {OBJECTIVE: To compare the distribution and assess genetic associations of the PTPN22 R620W single-nucleotide polymorphism among South Asian (Asiatic Indian) patients with rheumatoid arthritis (RA) and ethnically matched controls. METHODS: DNA samples from 133 rheumatoid factor-positive South Asian RA patients and 149 control subjects from the East Midlands of the UK were genotyped for PTPN22 R620W polymorphism. Genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism method. RESULTS: The PTPN22 *T allele frequency was lower than in the Caucasian populations, but the disease association was significant (odds ratio 5.87, 95\% confidence interval 1.68-20.52). Similar association was observed for genotypes containing *T allele. CONCLUSION: Our results suggest that the T variant acts as a susceptibility allele for autoantibody-positive RA among South Asians.}, issn = {0315-162X}, URL = {https://www.jrheum.org/content/34/10/1984}, eprint = {https://www.jrheum.org/content/34/10/1984.full.pdf}, journal = {The Journal of Rheumatology} }