RT Journal Article
SR Electronic
T1 Neurological complications of infliximab.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1018
OP 1020
VO 33
IS 5
A1 Jarand, Julie
A1 Zochodne, Douglas W
A1 Martin, Liam O
A1 Voll, Christopher
YR 2006
UL http://www.jrheum.org/content/33/5/1018.abstract
AB The use of anti-tumor necrosis factor-a (TNF-a) therapies has led to improved outcomes in the treatment of rheumatoid arthritis (RA). However, the use of these new therapeutic agents requires careful monitoring for adverse effects. We describe 3 patients who developed neurological disease closely associated with the use of infliximab, a monoclonal antibody that binds to and inactivates TNF-a. All had evidence of polyneuropathy, demyelinating in one and axonal in 2. One patient had a central nervous system syndrome. Physicians should be aware of these potential adverse effects when treating patients with infliximab.