PT - JOURNAL ARTICLE AU - Julie Jarand AU - Douglas W Zochodne AU - Liam O Martin AU - Christopher Voll TI - Neurological complications of infliximab. DP - 2006 May 01 TA - The Journal of Rheumatology PG - 1018--1020 VI - 33 IP - 5 4099 - http://www.jrheum.org/content/33/5/1018.short 4100 - http://www.jrheum.org/content/33/5/1018.full SO - J Rheumatol2006 May 01; 33 AB - The use of anti-tumor necrosis factor-a (TNF-a) therapies has led to improved outcomes in the treatment of rheumatoid arthritis (RA). However, the use of these new therapeutic agents requires careful monitoring for adverse effects. We describe 3 patients who developed neurological disease closely associated with the use of infliximab, a monoclonal antibody that binds to and inactivates TNF-a. All had evidence of polyneuropathy, demyelinating in one and axonal in 2. One patient had a central nervous system syndrome. Physicians should be aware of these potential adverse effects when treating patients with infliximab.