RT Journal Article
SR Electronic
T1 Tumor necrosis factor-alpha inhibition and VATER association: a causal relationship.
JF The Journal of Rheumatology
JO J Rheumatol
FD The Journal of Rheumatology
SP 1014
OP 1017
VO 33
IS 5
A1 Carter, John D
A1 Valeriano, Joanne
A1 Vasey, Frank B
YR 2006
UL http://www.jrheum.org/content/33/5/1014.abstract
AB Inflammatory conditions that may require the use of a tumor necrosis factor-a (TNF-a) antagonist often involve women of child-bearing age. TNF-a antagonists are presumed to be safe in pregnancy based on animal data. However, this has never been formally studied in prospective trials involving humans. We describe a patient with psoriasis and psoriatic arthritis who took etanercept 50 mg subcutaneously (SQ) twice weekly throughout her pregnancy. She gave birth to a child with VATER association. Animal and human data exist to suggest a possible causal relationship between the mother's use of etanercept and the child's development of VATER association. We propose that the TNF antagonists, specifically etanercept, be used with caution in pregnant women. Patient registries of women who take TNF-a antagonists during pregnancy also need to be followed to see if there is an increase in the birth defects that are part of VATER association.