RT Journal Article SR Electronic T1 Increased expression of N-methyl-D-aspartate receptor subunit 2D in the skin of patients with fibromyalgia. JF The Journal of Rheumatology JO J Rheumatol FD The Journal of Rheumatology SP 785 OP 788 VO 33 IS 4 A1 Seong-Ho Kim A1 Tae Jung Jang A1 Il Soo Moon YR 2006 UL http://www.jrheum.org/content/33/4/785.abstract AB OBJECTIVE: We studied the expression of N-methyl-D-aspartate receptors (NMDAR) in skin of patients with fibromyalgia (FM) to investigate their role. METHODS: The presence of NMDAR subtype 2B (NR2B) and subtype 2D (NR2D) was examined in skin tissues by immunohistochemistry and immunoblot. Skin tissues from 11 female patients with FM were examined and compared to those of 8 age- and sex-matched healthy controls. RESULTS: NR2D expression was increased in the skin of patients with FM versus controls. There was no difference in the expression of NR2B between FM patients and controls. CONCLUSION: The increased expression of NMDAR found in FM skin could be indicative of a more generalized increase in other peripheral nerves. This suggests that NR2D-selective antagonists may have implications in the treatment of allodynia in patients with FM.