TY - JOUR T1 - Pantoprazole and perinuclear antineutrophil cytoplasmic antibody-associated vasculitis. JF - The Journal of Rheumatology JO - J Rheumatol SP - 629 LP - 632 VL - 33 IS - 3 AU - Dana Jacobs-Kosmin AU - Chris T Derk AU - Nora Sandorfi Y1 - 2006/03/01 UR - http://www.jrheum.org/content/33/3/629.abstract N2 - Systemic vasculitis may, at times, be drug-induced and associated with antineutrophil cytoplasmic antibodies (ANCA). However, pantoprazole, a commonly used and well-tolerated proton pump inhibitor, has not previously been reported to cause ANCA-associated syndromes. We describe a patient who developed interstitial nephritis, cutaneous vasculitis, a perinuclear ANCA staining pattern (pANCA) on immunofluorescence, and anti-myeloperoxidase antibodies (MPO-ANCA) in association with pantoprazole. We review various immune-mediated syndromes reported in association with proton pump inhibitors, including one report of omeprazole associated with interstitial nephritis and the development of ANCA. ER -