PT  - JOURNAL ARTICLE
AU  - Dana Jacobs-Kosmin
AU  - Chris T Derk
AU  - Nora Sandorfi
TI  - Pantoprazole and perinuclear antineutrophil cytoplasmic antibody-associated vasculitis.
DP  - 2006 Mar 01
TA  - The Journal of Rheumatology
PG  - 629--632
VI  - 33
IP  - 3
4099  - http://www.jrheum.org/content/33/3/629.short
4100  - http://www.jrheum.org/content/33/3/629.full
SO  - J Rheumatol2006 Mar 01; 33
AB  - Systemic vasculitis may, at times, be drug-induced and associated with antineutrophil cytoplasmic antibodies (ANCA). However, pantoprazole, a commonly used and well-tolerated proton pump inhibitor, has not previously been reported to cause ANCA-associated syndromes. We describe a patient who developed interstitial nephritis, cutaneous vasculitis, a perinuclear ANCA staining pattern (pANCA) on immunofluorescence, and anti-myeloperoxidase antibodies (MPO-ANCA) in association with pantoprazole. We review various immune-mediated syndromes reported in association with proton pump inhibitors, including one report of omeprazole associated with interstitial nephritis and the development of ANCA.