PT  - JOURNAL ARTICLE
AU  - Luca Bertinotti
AU  - Marzia Mortilla
AU  - Maria Letizia Conforti
AU  - Nicola Colangelo
AU  - Francesca Nacci
AU  - Angela Del Rosso
AU  - Claudio Fonda
AU  - Roberto Casale
AU  - Marco Matucci-Cerinic
AU  - Alberto Pignone
TI  - Proton magnetic resonance spectroscopy reveals central neuroaxonal impairment in systemic sclerosis.
DP  - 2006 Mar 01
TA  - The Journal of Rheumatology
PG  - 546--551
VI  - 33
IP  - 3
4099  - http://www.jrheum.org/content/33/3/546.short
4100  - http://www.jrheum.org/content/33/3/546.full
SO  - J Rheumatol2006 Mar 01; 33
AB  - OBJECTIVE:. Involvement of the central nervous system (CNS) in systemic sclerosis (SSc) is rare. Proton magnetic resonance spectroscopy (1H-MRS) assesses in vivo cerebral metabolites. We investigated the biochemical modifications of the CNS in SSc. METHODS: N-acetylaspartate/creatine ratio (NAA/Cr) and choline/creatine ratio (Cho/Cr) at right centrum semiovale (RCS) and at right basal ganglia (RBG) were evaluated by 1H-MRS in 12 patients with limited (lSSc) and 8 patients with diffuse SSc (dSSc) and 20 control subjects. RESULTS: With 1H-MRS, a significant reduction of NAA/Cr ratio at RBG (p < 0.02) and at RCS (p < 0.002) was detected in SSc patients. Cho/Cr ratio was increased (p < 0.02) in the RCS, but not in RBG. In patients with lSSc, a significant reduction of NAA/Cr was detected in RCS but not in RBG. CONCLUSION: Evidence of neuroaxonal damage strongly suggests the existence of CNS involvement in SSc.