Ganglion cysts are common periarticular/peritendinous masses, which are thought to form from myxoid degeneration of collagen that becomes encased by connective tissue.1 This differentiates them from synovial cysts, which are lined by synovium.2,3 The presence of numerous ganglion cysts in multiple locations is very rare and has been termed cystic ganglionosis.4
A 3-year-old male was referred with concern for juvenile idiopathic arthritis (JIA). Brain magnetic resonance imaging, performed for unrelated reasons, showed cystic lesions at the temporomandibular joints (TMJs) and atlantoaxial articulations, suggestive of joint effusions (Figure 1).
Clinical history was negative for joint pain or swelling, and family history was negative for rheumatologic conditions. His musculoskeletal examination was normal. A complete blood count was normal, and he was negative for antinuclear antibodies and rheumatoid factor. An alternative diagnosis of cystic ganglionosis was considered due to the lack of rheumatologic findings. Ultrasound of the hands/wrists was performed to screen for other lesions and showed multiple asymptomatic ganglion cysts (Figure 2). During the follow-up period, the patient has remained asymptomatic without treatment.
We found only 4 other case reports of cystic ganglionosis, 3 of which were on children.5,6,7 Management is usually conservative unless a lesion is symptomatic. This case highlights that cystic ganglionosis can mimic joint effusions in small joints such as the TMJs, leading to concern for JIA, which was also a diagnostic consideration in another report of cystic ganglionosis.5 The detection of numerous ganglion cysts and absence of other findings of arthritis should lead to the consideration of cystic ganglionosis to avoid unnecessary treatment.
Footnotes
The authors declare no conflicts of interest relevant to this article. Written consent to publish the case was obtained from the patient’s family. Case reports do not require IRB approval according to the authors’ institutions.
- © 2022 by the Journal of Rheumatology
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