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(REFERENCES)Tj
/T1_2 1 Tf
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[(1.)-875.1 (Pritzker KPH, Kessler MJ. Diseases of the musculoskeletal system.)]TJ
1.675 -1.25 Td
[(In: Bennett BT)73.9 (, )54.8 (Abee CR, Henrickson R, editors. Nonhuman)]TJ
T*
[(primates in biomedical research: diseases. San Diego: )54.8 (Academic)]TJ
T*
(Press Inc.; 1998:415-59.)Tj
-1.675 -1.25 Td
[(2.)-875.1 (Kandel RA, Renlund RC, Cheng P-T)73.9 (, Rapley )17.7 (W)110.9 (A, Mehren KG,)]TJ
1.675 -1.25 Td
(Pritzker KPH. Calcium pyrophosphate dihydrate crystal deposition)Tj
T*
(disease with concurrent vertebral hyperostosis in a Barbary ape.)Tj
T*
(Arthritis Rheum 1983;26:682-7.)Tj
-1.675 -1.25 Td
[(3.)-875.1 (Pritzker KPH, Chateauvert J, Grynpas MD, Renlund RC, )17.7 (T)35 (urnquist)]TJ
1.675 -1.25 Td
(J, Kessler MJ. Rhesus macaques as an experimental model for)Tj
T*
(degenerative arthritis. Puerto Rico Health Sci J 1989;8:99-102.)Tj
31.325 70.171 Td
[(4.)-875.1 (Renlund RC, Pritzker KPH, Kessler MJ. Rhesus monkey \(Macaca)]TJ
1.675 -1.25 Td
(mulatta\) as a model for calcium pyrophosphate dihydrate crystal)Tj
T*
[(deposition disease. J Med Primatol 1986;15:1)36.8 (1-6.)]TJ
-1.675 -1.25 Td
[(5.)-875.1 (Roberts ED, Baskin GB, )17.7 (W)79.9 (atson E, Henk )17.7 (WG, Shelton )17.7 (TC.)]TJ
1.675 -1.25 Td
(Calcium pyrophosphate deposition disease \(CPPD\) in nonhuman)Tj
T*
[(primates. )54.8 (Am J Pathol 1984;1)36.8 (16:359-61.)]TJ
-1.675 -1.25 Td
[(6.)-875.1 (Carlson CS, Loeser RF)79.7 (, Jayo MJ, )17.7 (W)79.9 (eaver DS, )54.8 (Adams MR, Jerome)]TJ
1.675 -1.25 Td
[(CP)110.7 (. Osteoarthritis in cynomolgus macaques: a primate model of)]TJ
T*
(naturally occurring disease. J Orthop Res 1994;12:331-9.)Tj
-1.675 -1.25 Td
[(7.)-875.1 (Chateauvert JMD, Pritzker KPH, Kessler MJ, Grynpas MD.)]TJ
1.675 -1.25 Td
(Spontaneous osteoarthritis in rhesus macaques. I. Chemical and)Tj
T*
(biochemical studies. J Rheumatol 1989;16:1098-104.)Tj
-1.675 -1.25 Td
[(8.)-875.1 (Chateauvert JMD, Grynpas MD, Kessler MJ, Pritzker KPH.)]TJ
1.675 -1.25 Td
(Spontaneous osteoarthritis in rhesus macaques. II. Characterization)Tj
T*
(of disease and morphometric studies. J Rheumatol 1990;17:73-83.)Tj
-1.675 -1.25 Td
[(9.)-875.1 (Gahunia HK, Lemaire C, Babyn PS, Cross )54.8 (AR, Kessler MJ,)]TJ
1.675 -1.25 Td
(Pritzker KPH. Osteoarthritis in rhesus macaque knee joint:)Tj
T*
(quantitative magnetic resonance imaging tissue characterization of)Tj
T*
(articular cartilage. J Rheumatol 1995;22:1747-56.)Tj
-2.175 -1.25 Td
[(10.)-875.1 (Pritzker KPH, Chateauvert JMD, Grynpas MD, Kessler MJ. Studies)]TJ
2.175 -1.25 Td
(of naturally degenerative arthritis in rhesus macaques as a model)Tj
T*
[(for degenerative arthritis in man. In: Maroudas )54.8 (A, Kuettner KE,)]TJ
T*
[(editors. Methods in cartilage research. London: )54.8 (Academic Press;)]TJ
0 Tc 0 Tw T*
(1990:341-2.)Tj
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[(1)36.8 (1)-0.1 (.)-875.1 (Chapman )17.7 (WL)-238.2 (Jr)39.7 (, Crowell )17.7 (W)110.9 (A. )54.8 (Amyloidosis in rhesus monkeys)]TJ
2.1381 -1.25 Td
[(with rheumatoid arthritis and enterocolitis. J )54.8 (Am )17.7 (V)110.8 (et Med )54.8 (Assoc)]TJ
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(1977;171:855-8.)Tj
-0.00011 Tc 0.02499 Tw -2.175 -1.25 Td
[(12.)-875.1 (Brown )17.7 (TM, Clark HW)91.7 (, Bailey JS, Gray CW)91.7 (. )54.8 (A)-220.1 (mechanistic)]TJ
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[(occurring in a gorilla. )17.7 (T)35 (rans )54.8 (Am Clin Climatol )54.8 (Assoc 1970;)]TJ
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(82:227-47.)Tj
-0.00011 Tc 0.02499 Tw -2.175 -1.25 Td
[(13.)-875.1 (Brown )17.7 (TM, Clark HW)91.7 (, Bailey JS. Natural occurrence of)]TJ
2.175 -1.25 Td
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T*
(Zool Soc Phil Centennial Symp 1974;43-79.)Tj
-2.175 -1.25 Td
[(14.)-875.1 (Hess EV)128.8 (, Kramer L, Linnemann CC, Herzig E, )54.8 (Adams LE, Balz G.)]TJ
2.175 -1.25 Td
[(Arthritis in gorillas [abstract]. )54.8 (Arthritis Rheum 1983;26 Suppl:S56.)]TJ
-2.175 -1.25 Td
[(15.)-875.1 (Raphael BL, Calle PP)110.7 (, Haramati N, )17.7 (W)79.9 (atkins DJ, Stetter MD, Cook)]TJ
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(RA. Reactive arthritis subsequent to Shigella flexneri enteritis in)Tj
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(Med 1995;26:132-8.)Tj
-0.00011 Tc -2.175 -1.25 Td
[(16.)-875.1 (Rothschild BM, )17.7 (W)79.9 (oods RJ. Spondyloarthropathy in gorillas. Semin)]TJ
2.175 -1.25 Td
(Arthritis Rheum 1989;18:267-76.)Tj
-2.175 -1.25 Td
[(17.)-875.1 (Urvater JA, Hickman H, Dzuris JL, et al. Gorillas with)]TJ
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(spondyloarthropathies express an MHC class I molecule with only)Tj
T*
(limited sequence similarity to HLA-B27 that binds peptides with)Tj
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[(ar)17.7 (ginine at P2. J Immunol 2001;166:3334-4.)]TJ
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[(18.)-875.1 (Neif)17.7 (fer DL, Rothschild BM, Marks SK, Urvater JA, )17.7 (W)79.9 (atkins DI.)]TJ
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(Management of reactive arthritis in a juvenile gorilla \(Gorilla)Tj
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(Med 2000;31:539-51.)Tj
-0.00011 Tc -2.175 -1.25 Td
[(19.)-875.1 (Hyrich KL, Kim )17.7 (T)91.9 (-H, Payne U, et al. Common aspects of human)]TJ
2.175 -1.25 Td
(and primate seronegative arthritis. J Rheumatol 2004;31:2300-4.)Tj
-2.175 -1.25 Td
[(20.)-875.1 (Benirschke K, )54.8 (Adams FD. Gorilla diseases and causes of death. )]TJ
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