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(primary risk factors for BD, and an attractive hypothesis is)Tj
0 Tc 0.1284 Tw 0 -1.2 TD
(that BD was spread in parallel with the distribution of its)Tj
0.3624 Tw T*
(associated allele by population movement between the)Tj
0.233 Tw T*
[(Mediterranean and )54.9 (Asia along the Silk Route. However)39.8 (,)]TJ
-0.00011 Tc 0.0778 Tw T*
(since around 43% of Italian patients were HLA-B51 nega-)Tj
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(tive, a contributory role of some other genes and/or envi-)Tj
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[(ronmental factors is likely)64.9 (.)]TJ
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[(W)79.7 (e evaluated HLA-B51 and MICA-TM allele associa-)]TJ
0 Tc -0.01579 Tw -1.2 -1.2 Td
[(tions in 69 Italian patients with BD. )17.8 (W)79.8 (e)0.1 ( found a strong asso-)]TJ
0.2863 Tw T*
(ciation with HLA-B51, but only a nonsignificant slight)Tj
-0.00011 Tc 0.24409 Tw T*
(increase of MICA-A6 in patients with BD compared to)Tj
0 Tc 0.0724 Tw T*
[(ethnically matched healthy controls. )54.9 (A)-267.3 (strong linkage dise-)]TJ
0.13989 Tw T*
(quilibrium in patients and controls was observed between)Tj
-0.00011 Tc 0.15021 Tw T*
[(HLA-B51 and MICA-A6 allele. )17.7 (Thus, the possibility that)]TJ
0 Tc 0.0222 Tw T*
[(the MICA)-217.4 (gene is primarily involved in the pathogenesis of)]TJ
-0.0054 Tw T*
(BD can be excluded, supporting the hypothesis of a primary)Tj
-0.00011 Tc 0.02499 Tw T*
(association of BD with HLA-B51. )Tj
/TT1 1 Tf
0 Tw 0 -2.4 TD
(REFERENCES)Tj
/TT0 1 Tf
0 Tc 0.0249 Tw 8 0 0 8 61 487.1616 Tm
[(1.)-875 (Barnes CG, )36.8 (Y)100.1 (azici H. Beh\347et\222)54.9 (s syndrome. Rheumatology)]TJ
0 Tw 1.675 -1.25 Td
[(1999;38:1)36.9 (171-6.)]TJ
0.0249 Tw -1.675 -1.25 Td
[(2.)-875 (Sakane )17.7 (T)74 (, )17.7 (T)69.8 (akeno M, Suzuki N, Inaba G. Beh\347et\222)54.9 (s disease. N Engl)]TJ
1.675 -1.25 Td
(J Med 1999;341:1284-91.)Tj
-0.00011 Tc -1.675 -1.25 Td
[(3.)-875.1 (Ohno S, Ohguchi M, Hirose S, Matsuda H, )17.7 (W)79.7 (akisaka )54.8 (A, )54.8 (Aizawa M.)]TJ
1.675 -1.25 Td
[(Close association of HLA-Bw51 with Beh\347et\222)54.8 (s disease. )54.8 (Arch)]TJ
0 Tc 0 -1.25 TD
(Ophthalmol 1982;100:1455-8.)Tj
-0.00011 Tc -1.675 -1.25 Td
[(4.)-875.1 (Mizuki N, Ohno S, )17.7 (T)69.7 (anaka H, et al. )54.8 (Association of HLA-B51 and)]TJ
1.675 -1.25 Td
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(Antigens 1992;40:22-30.)Tj
-1.675 -1.25 Td
[(5.)-875 (V)111.1 (erity DH, Marr JE, Ohno S, )17.7 (W)79.8 (a)0.1 (llace GR, Stanford MR. Beh\347et\222)54.9 (s)]TJ
1.675 -1.25 Td
(disease, the Silk Road and HLA-B51: historical and geographical)Tj
0.0072 Tw T*
[(perspectives. T)34.9 (issue )37.1 (Antigens )-17.8 (1999;54:213-20.)]TJ
-0.00011 Tc 0.02499 Tw -1.675 -1.25 Td
[(6.)-875.1 (Bahram S, Bresnahan M, Geraghty DE, Spies )17.7 (T)73.9 (.)-0.1 ( )54.8 (A)-219.9 (second lineage)]TJ
0 Tc 1.675 -1.25 Td
(of mammalian major histocompatibility complex class I genes. Proc)Tj
-0.00011 Tc T*
[(Natl )54.8 (Acad Sci USA)-220.2 (1994;91:6259-63.)]TJ
0 Tc -1.675 -1.25 Td
[(7.)-875 (Fodil N, Laloux L, )17.8 (W)79.8 (anner )17.8 (V)129.1 (, et al. )54.9 (Allelic repertoire of the human)]TJ
1.675 -1.25 Td
[(MHC class I MICA)-220.1 (gene. Immunogenetics 1996;44:351-7.)]TJ
-1.675 -1.25 Td
[(8.)-875 (Fodil N, Pellet P)110.8 (, Laloux L, Hauptmann G, )17.7 (Theodorou I, Bahram S.)]TJ
1.675 -1.25 Td
[(MICA)-220.1 (haplotypic diversity)64.9 (. Immunogenetics 1999;49:557-60.)]TJ
-0.00011 Tc -1.675 -1.25 Td
[(9.)-875.1 (Zwirner NW)91.7 (, Fernandez-V)59.7 (ina MA, Stastny P)110.7 (. MICA, a new)]TJ
0 Tc 1.675 -1.25 Td
(polymorphic HLA-related antigen, is expressed mainly by)Tj
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(keratinocytes, endothelial cells, and monocytes. Immunogenetic)Tj
0 Tw T*
(1998;47:139-48.)Tj
0.0249 Tw 30.825 57.171 Td
[(10.)-875 (Mizuki N, Ota M, Kimura M, et al. )17.7 (T)34.9 (riplet repeat polymorphism in)]TJ
-0.00011 Tc 2.175 -1.25 Td
[(the transmembrane region of the MICA)-220.2 (gene: a strong association)]TJ
0 Tc T*
[(of six GCT)-257.2 (repetitions with Beh\347et disease. Proc Natl )54.8 (Acad Sci)]TJ
-0.00011 Tc 0 Tw T*
[(USA)-220.2 (1997;94:1298-303.)]TJ
0.02499 Tw -2.1381 -1.25 Td
[(1)36.8 (1)-0.1 (.)-875.1 (P\351rez-Rodriguez M, Corell )54.8 (A, )54.8 (Ar)17.7 (g\373ello JR, et al. )54.8 (A)-219.9 (new MICA)]TJ
0 Tc 2.1381 -1.25 Td
[(allele with ten alanine residues in the exon 5 microsatellite. )17.8 (T)34.9 (issue)]TJ
T*
(Antigens 2000;55:162-5.)Tj
-2.175 -1.25 Td
[(12.)-875 (Y)100.1 (abuki K, Mizuki N, Ota M, et al. )54.8 (Association of MICA)-220.1 (gene and)]TJ
-0.00011 Tc 2.175 -1.25 Td
[(HLA-B*5101 with Beh\347et\222)54.8 (s disease in Greece. Invest Ophthalmol)]TJ
0 Tc T*
[(V)60.1 (is Sci 1999;40:1921-6.)]TJ
-0.00011 Tc -2.175 -1.25 Td
[(13.)-875.1 (W)79.7 (allace GR, )17.7 (V)111 (erity DH, Delamaine LJ, et al. MIC-A)-220.2 (allele profiles)]TJ
2.175 -1.25 Td
[(and HLA)-220.2 (class I associations in Beh\347et\222)54.8 (s disease. Immunogenetics)]TJ
0 Tc 0 Tw T*
(1999;49:613-7.)Tj
-0.00011 Tc -0.0298 Tw -2.175 -1.25 Td
[(14.)-875.1 (Gonzalez-Escribano )-54.8 (MF)79.7 (, )-54.9 (Rodriguez )-54.9 (MR, Aguilar )-54.8 (F)79.7 (,)-0.1 ( Alvarez A,)]TJ
0.02499 Tw 2.175 -1.25 Td
[(Sanchez-Roman J, Nunez-Roldan )54.8 (A. Lack of association of MICA)]TJ
0 Tc T*
[(transmembrane region polymorphism and Beh\347et\222)54.9 (s disease in)]TJ
0.0072 Tw T*
[(Spain. T)34.9 (issue )37.1 (Antigens )-17.8 (1999;54:278-81.)]TJ
-0.00011 Tc 0.02499 Tw -2.175 -1.25 Td
[(15.)-875.1 (International Study Group for Beh\347et\222)54.8 (s disease. Criteria for)]TJ
0 Tc 2.175 -1.25 Td
[(diagnosis of Beh\347et\222)54.9 (s disease. Lancet 1990;335:1078-80.)]TJ
-0.00011 Tc -2.175 -1.25 Td
[(16.)-875.1 (T)69.7 (erasaki PI, McClelland JD. Microdroplet assay for human serum)]TJ
0 Tc 2.175 -1.25 Td
(cytotoxins. Nature 1964;204:998-1000.)Tj
-2.175 -1.25 Td
[(17.)-875 (Lehner )17.7 (T)74 (. Immunopathogenesis of Beh\347et\222)54.9 (s disease. )54.8 (Ann Med)]TJ
2.175 -1.25 Td
(Interne 1999;150:483-7.)Tj
-2.175 -1.25 Td
[(18.)-875 (Y)100.1 (amashita N. Hyperreactivity of neutrophils and abnormal )17.8 (T)-257.2 (cell)]TJ
2.175 -1.25 Td
[(homeostasis: a new insight for pathogenesis of Beh\347et\222)54.9 (s disease. Int)]TJ
T*
[(Rev Immunol 1997;14:1)36.9 (1-9.)]TJ
-2.175 -1.25 Td
[(19.)-875 (T)69.8 (akeno M, Kariyone )54.9 (A, )36.9 (Y)100.1 (amashita N, et al. Excessive function of)]TJ
2.175 -1.25 Td
[(peripheral blood neutrophils from patients with Beh\347et\222)54.9 (s disease)]TJ
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[(and from HLA-B51 transgenic mice. )54.8 (Arthritis Rheum )]TJ
0 Tc 0 Tw T*
(1995;38:426-33.)Tj
0.0249 Tw -2.175 -1.25 Td
[(20.)-875 (Sensi )54.8 (A, Gavioli R, Spisani S, et al. HLA)-220.1 (B51 antigen associated)]TJ
2.175 -1.25 Td
[(with neutrophil hyper)19.8 (-reactivity)64.9 (. Dis Markers 1991;9:327-31.)]TJ
-0.00011 Tc -2.175 -1.25 Td
[(21.)-875.1 (Groh )17.7 (V)129 (, Bahram S, Bauer S, Herman )54.8 (A, Beauchamp M, Spies )17.7 (T)73.9 (.)]TJ
0 Tc 2.175 -1.25 Td
(Cell stress-regulated human major histocompatibility complex class)Tj
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[(I gene expressed in gastrointestinal epithelium. Proc Natl )54.8 (Acad Sci)]TJ
-0.00011 Tc 0 Tw T*
[(USA)-220.2 (1996;93:12445-50.)]TJ
0 Tc 0.0249 Tw -2.175 -1.25 Td
[(22.)-875 (Groh )17.7 (V)129.1 (, Steinle )54.8 (A, Bauer S, Spies )17.7 (T)74 (. Recognition of stress-induced)]TJ
2.175 -1.25 Td
[(MHC molecules by intestinal epithelial gamma delta )17.8 (T)-257.2 (cells.)]TJ
T*
(Science 1998;279:1737-40.)Tj
-0.00011 Tc -2.175 -1.25 Td
[(23.)-875.1 (Baricordi OR, Sensi )54.8 (A, Pivetti-Pezzi P)110.7 (,)-0.1 ( et al. Beh\347et\222)54.8 (s disease)]TJ
0 Tc 2.175 -1.25 Td
(associated with HLA-B51 and DRw52 antigens in Italians. Hum)Tj
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(Immunol 1986;17:297-301.)Tj
-0.00011 Tc -2.175 -1.25 Td
[(24.)-875.1 (Mizuki N, Ota M, Katsuyama )36.8 (Y)129.1 (,)-0.1 ( et al. )54.8 (Association analysis between)]TJ
0 Tc 2.175 -1.25 Td
[(the MIC-A)-220.1 (and HLA-B alleles in Japanese patients with Beh\347et\222)54.9 (s)]TJ
T*
[(disease. )54.9 (Arthritis Rheum 1999;42:1961-6.)]TJ
ET
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558 54 l
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8 0 0 8 424.3613 35.9844 Tm
(The Journal of Rheumatology 2001; 28:8)Tj
0 Tw -46.2952 -0.0313 Td
(1870)Tj
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