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0 792.06 612 -792 re
W n
BT
/CS0 cs 0 0 0 1 scn
/GS1 gs
/TT0 1 Tf
-0.00999 Tc 0.15669 Tw 8 0 0 8 54 714.5293 Tm
[(1996: inflammatory pain in ankles and shoulders. Morning stif)17.5 (fness: 2 h.)]TJ
0.17 Tw 0 -1.225 TD
(Antinuclear antibodies positive \(1:100, homogeneous\). Latex positive [\
48)Tj
0.095 Tw T*
[(IU/ml \(normal range < 25\)], Rose-W)79.6 (aaler dubious [10 IU \(normal range <)]TJ
0.02811 Tw T*
[(12\)], RF-IgM ELISA)-213.4 (positive \(0.258; normal < 0.200\). HLA- B27 negative,)]TJ
0.0273 Tw T*
[(DRB1 0707, DQB1 0202 \(homozygous for both\). ESR = 28 mm; CRP)-230.8 (= 15)]TJ
-0.0096 Tw T*
[(mg/l. January 1998: synovitis of knees and ankles. MCP)-193.9 (left IV)-212.7 (and PIP)-193.6 (right)]TJ
0.0939 Tw T*
[(II tender on palpation. May 1998: Morning stif)17.6 (fness > 1 h \(knees mainly\).)]TJ
0.0688 Tw T*
[(T)69.7 (enderness of MCP)-272.1 (left IV)-291.1 (and III, right III and II. Slight arthritis of knees)]TJ
0.1451 Tw T*
(and ankles. Patient denies other present or past symptoms, and especiall\
y)Tj
0.3219 Tw T*
(gastrointestinal, urogenital or ocular signs. X-rays \(pelvis, feet, han\
ds\))Tj
0.02499 Tw T*
(normal. Overall followup: 28 months.)Tj
/TT1 1 Tf
-0.02119 Tw 0 -2.45 TD
(Case 6.)Tj
/TT0 1 Tf
3.0726 0 Td
[(A)-163.7 (53-year)19.7 (-old Caucasian female. Family history: mother suf)17.6 (fers from)]TJ
0.12691 Tw -3.0726 -1.225 Td
[(polymyalgia rheumatica. No significant personal history)64.6 (. July 1995: knees)]TJ
0.0807 Tw 0 -1.225 TD
[(and right PIP)-284 (III painful and swollen. November 1995: right wrist, MCP)-284.3 (II)]TJ
0.01981 Tw T*
[(and III \(left\), II and III and IV)-242.2 (\(right\) painful and swollen. Morning stif)17.5 (fness)]TJ
0.0695 Tw T*
[(= 90 min for 2 months. ESR = 12 mm; CRP)-272.9 (= 4 mg/l. Latex, Rose-W)79.7 (aaler)]TJ
-0.00529 Tw T*
[(and RF-ELISA)-179.9 (negative. )54.8 (Antinuclear antibodies negative. HLA-B7 and B12,)]TJ
-0.00571 Tc 0.3707 Tw T*
[(DRB1 15 \(homozygous\). )54.8 (April 1996: left knee painful and swollen.)]TJ
-0.00999 Tc 0.0419 Tw T*
(November 1996: left knee painful and swollen. November 1996: tenderness)Tj
-0.0329 Tw T*
[(of left sternoclavicular joint. Synovitis of left knee, PIP)-170.6 (I)0.4 (V)-189.3 (right, DIP)-170.3 (III right.)]TJ
0.03101 Tw T*
[(October 1997: enthesopathy of the right )54.7 (Achilles tendon. June 1998: DIP)-234.3 (III)]TJ
-0.0034 Tw T*
(right painful and swollen. Patient denies other present or past symptoms\
, and)Tj
0.17171 Tw T*
(especially dermatological, urogenital or ocular signs. X-rays \(pelvis, \
feet,)Tj
0.02499 Tw T*
(hands\) normal. Overall followup: 35 months.)Tj
/TT1 1 Tf
0.2285 Tw 0 -2.45 TD
(Case 7.)Tj
/TT0 1 Tf
0.22861 Tw 3.5719 0 Td
[(A)-413.4 (53-year)19.6 (-old Caucasian female. No family history of arthritis;)]TJ
0.0858 Tw -3.5719 -1.225 Td
(personal history of psoriasis. November 1995: synovitis of left knee. Ri\
ght)Tj
0.0425 Tw 0 -1.225 TD
[(toe IV)-264.9 (painful and swollen like a sausage for 3 months. Morning stif)17.5 (fness =)]TJ
0.1523 Tw T*
[(15 min. ESR = 80 mm; CRP)-355.7 (= 35 mg/l. Latex, Rose-W)79.7 (aaler)39.8 (, RF-ELISA)]TJ
0.0006 Tw T*
[(negative. )54.9 (Antinuclear antibodies negative. HLA-B7 and B27. HLA-DR1 and)]TJ
-0.0016 Tw T*
(DR15. November 1995 to 1997: no pain. October 1997: inflammatory spinal)Tj
0.0504 Tw T*
(pain for 3 months. Enthesopathy of the elbows. Patient denies other pres\
ent)Tj
0.0248 Tw T*
(or past symptoms, and especially gastrointestinal, urogenital or ocular \
signs.)Tj
0.02499 Tw T*
(X-rays \(pelvis, feet, hands\) normal. Overall followup: 24 months.)Tj
/TT1 1 Tf
0.36211 Tw 0 -2.4625 TD
(Case 8.)Tj
/TT0 1 Tf
3.8392 0 Td
[(A)-547 (37-year)19.7 (-old Caucasian male. Family history of ankylosing)]TJ
-0.0098 Tc 0.0023 Tw -3.8392 -1.2375 Td
(spondylitis \(5 cases\). November 1995: synovitis of the right knee, rig\
ht wrist)Tj
-0.00999 Tc 0.02029 Tw 0 -1.2375 TD
(and left ankle for 3 months. Inflammatory spinal pain improved by exerci\
se.)Tj
-0.02831 Tw T*
[(Morning stif)17.8 (fness of joints: 90 min. ESR = 14 mm; CRP)-175.1 (= 10 mg/l. Latex and)]TJ
0.0405 Tw T*
[(RF-IgM \(ELISA\) negative. )54.7 (Anti-nuclear antibodies negative. HLA-B14 and)]TJ
0.1646 Tw T*
(B40. HLA-DRB1 04 and 15. November 1995 to October 1997: transient)Tj
0.0782 Tw T*
(inflammatory spinal pain for 3 months. Patient denies other present or p\
ast)Tj
0.0233 Tw T*
(symptoms, and especially gastrointestinal, urogenital or ocular signs. X\
-rays)Tj
0.02499 Tw T*
(\(pelvis, feet, hands\) normal. Overall followup: 23 months.)Tj
/TT1 1 Tf
0.1102 Tw 0 -2.475 TD
(Case 9.)Tj
/TT0 1 Tf
3.3353 0 Td
[(A)-295.1 (31-year)19.7 (-old Caucasian female. No family or personal history of)]TJ
-0.0201 Tw -3.3353 -1.2375 Td
[(arthritis. December 1995: synovitis of the right wrist, right PIP)-183.4 (IV)128.8 (, right MCP)]TJ
0.21159 Tw 0 -1.2375 TD
[(IV)128.8 (, and left MCP)-415 (II. Shoulders, right MTP)-415 (IV)-433.9 (and left MTP)-414.9 (II painful.)]TJ
-0.03461 Tw T*
[(Morning stif)17.8 (fness = 2 h. ESR = 40 mm; CRP)-168.8 (= 57 mg/l. Latex and RF-ELISA)]TJ
-0.0127 Tw T*
[([0.162 \(normal < 0.200\)] negative. )54.7 (Antinuclear antibodies negative. HLA-B8)]TJ
-0.0112 Tw T*
(and B44. HLA-DRB1 04 and 07. July 1996: synovitis of the right wrist, ri\
ght)Tj
0.0311 Tw T*
[(MCP)-234.3 (IV)128.8 (, and right PIP)-216.6 (V)129.1 (.)-0.1 ( )54.8 (All MTP)-234.4 (painful. June 1998: synovitis of the right)]TJ
0.1691 Tw T*
[(wrist. )54.8 (All MTP)-372.4 (painful. Latex and RF-IgM still at the limit of positivity)64.6 (.)]TJ
0.26401 Tw T*
(Patient denies other present or past symptoms, and especially gastroin-)Tj
0.1142 Tw T*
[(testinal, urogenital or ocular signs. X-rays: feet = erosion of both MTP\
)-300 (V)74.1 (;)]TJ
0.0027 Tw T*
(hands = erosion and demineralisation of right wrist; pelvis = normal. Ov\
erall)Tj
0.02499 Tw T*
(followup: 31 months.)Tj
/TT1 1 Tf
0.1344 Tw 0 -2.45 TD
(Case 10.)Tj
/TT0 1 Tf
3.8738 0 Td
[(A)-319.3 (23-year)19.7 (-old Caucasian male. No family or personal history of)]TJ
0.0408 Tw -3.8738 -1.225 Td
[(arthritis. Father suf)17.6 (fering from psoriasis. March 1996: synovitis of right PIP)]TJ
0.05161 Tw 0 -1.225 TD
[(II-III, and left PIP)-255 (for 2 months. Morning stif)17.6 (fness = 15 min. ESR = 2 mm;)]TJ
0.0172 Tw T*
[(CRP)-220.4 (= 3 mg/l. Latex and RF-IgM negative. )54.7 (Antinuclear antibodies negative.)]TJ
0.0424 Tw T*
(HLA-B8 and B16. HLA-DRB1 01 and 07. October 1996: flare of psoriasis,)Tj
0.0106 Tw T*
[(but no more arthritis. September 1997 to )54.7 (April 1998: pain alternating in both)]TJ
0.25459 Tw T*
(buttocks. Patient denies other present or past symptoms, and especially)Tj
0.19791 Tw 33 79.8999 Td
(gastrointestinal, urogenital or ocular signs. X-rays \(pelvis, feet, han\
ds\) =)Tj
0.0249 Tw T*
(sacroiliitis. Overall followup: 26 months.)Tj
/TT2 1 Tf
-0.00011 Tc 0 Tw 10 0 0 10 318 682.7292 Tm
(REFERENCES)Tj
/TT0 1 Tf
0 Tc 0.0249 Tw 8 0 0 8 325 672.7293 Tm
[(1.)-875 (Emery P)110.8 (, Marzo H, Proudman S. Management of patients with)]TJ
1.675 -1.25 Td
(newly diagnosed rheumatoid arthritis. Rheumatology 1999;)Tj
0 -1.25 TD
(38 Suppl 2:27-31.)Tj
-1.675 -1.25 Td
[(2.)-875 (Mottonen )17.8 (T)74 (, Hannonen P)110.8 (, Leirisalo-Repo M, et al. Comparison of)]TJ
1.675 -1.25 Td
(combination therapy with single-drug therapy in early rheumatoid)Tj
-0.00011 Tc T*
(arthritis: a randomised trial. FIN-RACo trial group. Lancet)Tj
0 Tc 0 Tw T*
(1999;353:1568-73.)Tj
-0.00011 Tc 0.02499 Tw -1.675 -1.25 Td
[(3.)-875.1 (Pincus )17.7 (T)73.9 (, O\222Dell JR, Kremer JM. Combination therapy with)]TJ
0 Tc 1.675 -1.25 Td
(multiple disease-modifying anti-rheumatic drugs in rheumatoid)Tj
T*
[(arthritis: a preventive strategy)64.9 (. )54.9 (Ann Intern Med 1999;131:768-74.)]TJ
-1.675 -1.25 Td
[(4.)-875 (Fleischmann RM. Early diagnosis and treatment of rheumatoid)]TJ
1.675 -1.25 Td
(arthritis for improved outcomes: focus on etanercept, a new)Tj
T*
[(biologic response modifier)54.9 (. Clin )17.8 (Ther 1999;9:1429-42.)]TJ
-1.675 -1.25 Td
[(5.)-875 (Cannon GW)91.8 (. Methotrexate pulmonary toxicity)64.9 (. Rheum Dis Clin)]TJ
-0.02991 Tw 1.675 -1.25 Td
[(North Am )-54.9 (1997;23:917-37.)]TJ
0.0249 Tw -1.675 -1.25 Td
[(6.)-875 (Berthelot JM, Maugars )36.8 (Y)129.2 (, Hamidou M, et al. Pancytopenia and)]TJ
1.675 -1.25 Td
(severe cytopenia induced by low-dose methotrexate. Eight case-)Tj
-0.00011 Tc T*
(reports and a review of one hundred cases from the literature \(with)Tj
0 Tc T*
(twenty-four deaths\). Rev Rhum [Engl.Ed.] 1995;62:477-86.)Tj
-0.00011 Tc -1.675 -1.25 Td
[(7.)-875.1 (Arnett FC, Edworthy SM, Bloch DA, et al. )17.7 (The )54.8 (American)]TJ
1.675 -1.25 Td
[(Rheumatism )54.8 (Association 1987 revised criteria for the classification)]TJ
0 Tc T*
[(of rheumatoid arthritis. )54.8 (Arthritis Rheum 1988;31:315-24. )]TJ
-1.675 -1.25 Td
[(8.)-875 (Dougados M, van der Linden S, Juhlin R, et al. )17.8 (The European)]TJ
1.675 -1.25 Td
(spondylarthropathy study group preliminary criteria for the)Tj
T*
[(classification of spondylarthropathy)64.9 (. )54.8 (Arthritis Rheum)]TJ
0 Tw T*
(1991;34:1218-27.)Tj
0.02499 Tw -1.675 -1.25 Td
[(9.)-875 (Isom\344ki H, Raunio J, von Essen R, H\344meenkorpi R. Incidence of)]TJ
1.675 -1.25 Td
(inflammatory rheumatic diseases in Finland. Scand J Rheumatol)Tj
0 Tw T*
(1978;7:188-92.)Tj
-0.00011 Tc 0.02499 Tw -2.175 -1.25 Td
[(10.)-875.1 (V)111 (an der Horst Bruinsma IE, Speyer I, )17.7 (V)60 (isser H, Breedveld FC,)]TJ
2.175 -1.25 Td
[(Hazes JMW)91.7 (. Diagnosis and course of early-onset arthritis: results)]TJ
0 Tc T*
(of a special arthritis clinic compared to routine patient care. Br J)Tj
T*
(Rheumatol 1998;37:1084-8.)Tj
-0.00011 Tc -2.1381 -1.25 Td
[(1)36.8 (1)-0.1 (.)-875.1 (Harrison BJ, Silman )54.8 (AJ, Barrett EM, Scott DGI, Symmons DPM.)]TJ
2.1381 -1.25 Td
(Presence of psoriasis does not influence the presentation of short-)Tj
0 Tc T*
(term outcome of patients with early inflammatory polyarthritis. )Tj
T*
(J Rheumatol 1997;24:1744-9.)Tj
-2.175 -1.25 Td
[(12.)-875 (Zeidler H. Undif)17.8 (ferentiated arthritis and spondylarthropathy as a)]TJ
2.175 -1.25 Td
(major problem of diagnosis and classification. Scand J Rheumatol)Tj
T*
(1987;Suppl 65:54-62. )Tj
-2.175 -1.25 Td
[(13.)-875 (Zeidler H, Hulsemann JL. Benign polyarthritis and undif)17.8 (ferentiated)]TJ
2.175 -1.25 Td
(arthritis: an epidemiological terra incognita. Scand J Rheumatol)Tj
T*
(1989;Suppl 79:13-20.)Tj
-2.175 -1.25 Td
[(14.)-875 (Hulsemann JL, Zeidler H. Undif)17.8 (ferentiated arthritis in an early)]TJ
2.175 -1.25 Td
(synovitis outpatient clinic. Clin Exp Rheumatol 1995;13:37-43.)Tj
-0.00011 Tc -2.175 -1.25 Td
[(15.)-875.1 (Amor B, Dougados M, Listrat )17.7 (V)129.1 (,)-0.1 ( et al. )54.8 (Are classification criteria for)]TJ
0 Tc 2.175 -1.25 Td
(spondylarthropathy useful as diagnostic criteria? Rev Rhum [Eng)Tj
T*
(Ed] 1995;62:10-5.)Tj
-0.00011 Tc -2.175 -1.25 Td
[(16.)-875.1 (Harrison BJ, Symmons DPM, Barrett EM, Silman )54.8 (A. )17.7 (The perfor-)]TJ
2.175 -1.25 Td
[(mance of the 1987 )54.8 (ARA)-220.2 (classification criteria for rheumatoid)]TJ
0 Tc T*
(arthritis in a population-based cohort of patients with early)Tj
T*
(inflammatory polyarthritis. J Rheumatol 1998;25:2324-30.)Tj
-0.00011 Tc -2.175 -1.25 Td
[(17.)-875.1 (Kaarela K, Kauppi MJ, Lehtinen KES. )17.7 (The value of the )54.8 (ACR 1987)]TJ
0 Tc 2.175 -1.25 Td
(criteria in very early rheumatoid arthritis. Scand J Rheumatol)Tj
0 Tw T*
(1995;24:279-81.)Tj
0.0249 Tw -2.175 -1.25 Td
[(18.)-875 (El-Gabalawy HS, Goldbach-Mansky R, Smith D 2nd, et al.)]TJ
2.175 -1.25 Td
[(Association of HLA)-220.1 (alleles and clinical features in patients with)]TJ
T*
[(synovitis of recent onset. )54.9 (Arthritis Rheum 1999;42:1696-1705.)]TJ
-2.175 -1.25 Td
[(19.)-875 (Schumacher HR, Bardin )17.8 (T)74 (. )17.8 (The spondylarthropathies: classification)]TJ
2.175 -1.25 Td
(and diagnosis. Do we need new terminologies? Bailli\350res Clin)Tj
T*
(Rheumatol 1998;12:551-65.)Tj
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(Berthelot, et al: Paper cases of RA)Tj
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(Personal non-commercial use only. The Journal of Rheumatology Copyright\
\251 2001. All rights reserved.)Tj
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(www.jrheum.org)Tj
0 g
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-16.72996 0 Td
(Downloaded on March 29, 2024 from )Tj
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