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/TT0 1 Tf
0.09891 Tw 10 0 0 10 66 713.1616 Tm
[(W)79.8 (e employed samples from patients with active )54.9 (AOSD)]TJ
0.0137 Tw -1.2 -1.2 Td
(as a model of an acute phase reaction because of the known)Tj
-0.00011 Tc 0.0121 Tw 0 -1.2 TD
[(hyperferritinemia. )17.8 (The serum ferritin levels in active )54.9 (AOSD)]TJ
0 Tc 0.0905 Tw T*
(can even be higher than those reported in other conditions)Tj
0.1328 Tw T*
[(with acute phase reaction. )17.8 (The reason for these very high)]TJ
0.02499 Tw T*
[(levels is not clear)54.9 (.)]TJ
0.0004 Tw 1.2 -1.2 Td
(Suggestions for the mechanism causing this increase are:)Tj
-0.00011 Tc 0.2151 Tw -1.2 -1.2 Td
(\(1\) release from hepatic cells)Tj
0 Tc 0 Tw 6.5 0 0 6.5 178.6371 632.4615 Tm
(3)Tj
0.2151 Tw 10 0 0 10 186.5382 629.1616 Tm
(\(but not all patients have)Tj
0.0462 Tw -13.2538 -1.2 Td
(increased amounts of transaminases, so liver damage is not)Tj
0.0134 Tw T*
(present in all of them\); \(2\) induction by cytokines, irrespec-)Tj
0.09241 Tw T*
(tive of the body iron stores, but perhaps influenced by the)Tj
0.0242 Tw T*
(intracellular labile iron pool)Tj
0 Tw 6.5 0 0 6.5 166.6245 584.4615 Tm
(14)Tj
0.0242 Tw 10 0 0 10 173.1244 581.1616 Tm
(; \(3\) a reflection of histiocytic)Tj
0.31461 Tw -11.9124 -1.2 Td
(hyperactivity that may sometimes lead to the so-called)Tj
0.02499 Tw T*
(hemophagocytic syndrome)Tj
0 Tw 6.5 0 0 6.5 162.2725 560.4615 Tm
(5)Tj
10 0 0 10 165.5224 557.1616 Tm
(.)Tj
0.27161 Tw -9.9522 -1.2 Td
(It is beyond the scope of this retrospective study to)Tj
0.0128 Tw -1.2 -1.2 Td
[(discuss the value of these suggestions. But )54.9 (AOSD would be)]TJ
-0.0146 Tw T*
(a good clinical model for prospective studies of cytokines in)Tj
0.0058 Tw T*
(temporal relationship with ferritin synthesis, contribution of)Tj
-0.00011 Tc 0.2999 Tw T*
(isoferritins, iron content of ferritin, H- and L-forms of)Tj
0 Tc 0.0257 Tw T*
(ferritin in active and inactive periods of disease, taking into)Tj
-0.0127 Tw T*
(account the hematological state and determinants of the iron)Tj
-0.00011 Tc 0.0334 Tw T*
(status such as serum iron, transferrin, transferrin saturation,)Tj
0.0199 Tc 0.5536 Tw T*
(serum transferrin receptor and bone marrow iron.)Tj
0 Tc 0.1033 Tw T*
(Interesting questions remain concerning the mechanism of)Tj
0.02499 Tw T*
(the hyperferritinemia and the origin of the iron in ferritin.)Tj
0.1311 Tw 1.2 -1.22 Td
[(W)79.8 (e detected highly significant decreased levels of iron)]TJ
0.1573 Tw -1.2 -1.22 Td
(saturation of ferritin in all samples, compared to samples)Tj
0.1362 Tw 0 -1.22 TD
(from healthy controls, and in comparison to patients with)Tj
-0.00011 Tc 0 Tw T*
(hemochromatosis)Tj
-0.0567 Tc 6.5 0 0 6.5 124.5347 379.6617 Tm
(11)Tj
0 Tc 0.0795 Tw 10 0 0 10 130.666 376.3616 Tm
[(. )54.9 (Although the iron saturation of ferritin)]TJ
0.06441 Tw -7.6666 -1.22 Td
[(is significantly lower in )54.9 (AOSD, the total amount of iron in)]TJ
0.16299 Tw T*
[(the circulation \(T)69.8 (able 1\) is much higher than in controls.)]TJ
0.01221 Tw T*
(This is due to the extreme increase of ferritin during attacks)Tj
0.1035 Tw T*
[(of Still\222)54.9 (s disease. In spite of the increased total amount of)]TJ
0.14439 Tw T*
(iron, the soluble transferrin receptor concentrations in the)Tj
0.02609 Tw T*
(sera were high, indicating functional iron deficiency)Tj
0 Tw 6.5 0 0 6.5 264.6407 306.4617 Tm
(15)Tj
-0.00011 Tc 0.0085 Tw 10 0 0 10 271.1406 303.1617 Tm
(. This)Tj
0.158 Tw -21.7141 -1.22 Td
[(suggests that while )54.9 (AOSD is associated with a high total)]TJ
0 Tc 0.2601 Tw T*
(amount of iron, it is not beneficial because it probably)Tj
0.00481 Tc 0.3701 Tw T*
[(resides in the \223wrong\224 pool. )17.7 (The role of the ferritin)]TJ
-0.00011 Tc 0 Tw T*
(receptor)Tj
0 Tc 6.5 0 0 6.5 86.749 257.6616 Tm
(16)Tj
0.2282 Tw 10 0 0 10 98.0316 254.3617 Tm
(in the uptake of ferritin iron in erythroid and)Tj
0.02499 Tw -4.4032 -1.22 Td
[(hepatic cells is not clear)54.9 (.)]TJ
-0.00011 Tc 0.11749 Tw 1.2 -1.2 Td
[(Other studies on ferritin in )54.8 (AOSD have focused on the)]TJ
0 Tc 0.0452 Tw -1.2 -1.2 Td
(changes of its microheterogeneity \227 the glycosylated frac-)Tj
0.1837 Tw 0 -1.2 TD
(tion is low during attacks)Tj
0 Tw 6.5 0 0 6.5 162.4389 209.4617 Tm
(3)Tj
-0.00011 Tc 0.18381 Tw 10 0 0 10 170.0264 206.1617 Tm
(and remains so during remis-)Tj
0 Tw -11.6026 -1.2 Td
(sions)Tj
0 Tc 6.5 0 0 6.5 74.5566 197.4617 Tm
(17)Tj
-0.01489 Tw 10 0 0 10 81.0566 194.1617 Tm
[(. )17.8 (The link between these 2 phenomena is unclear)55 (. )17.8 (The)]TJ
0.21941 Tw -2.7057 -1.2 Td
(described changes in glycosylation of ferritin in patients)Tj
0.0536 Tw T*
[(with )54.9 (AOSD may play a role in the changed iron loading of)]TJ
-0.0018 Tw T*
(ferritin or may have consequences for the binding of ferritin)Tj
-0.00011 Tc 0.02499 Tw T*
(to its receptor)Tj
0 Tc 0 Tw 6.5 0 0 6.5 109.4732 149.4617 Tm
(16)Tj
10 0 0 10 115.9731 146.1617 Tm
(.)Tj
0.25819 Tw -4.9973 -1.2 Td
[(W)79.8 (e observed a negative correlation between the iron)]TJ
0.2444 Tw -1.2 -1.2 Td
(saturation of ferritin and the concentration of ferritin in)Tj
0.0067 Tc 0.36819 Tw T*
[(AOSD. )17.7 (This suggests that in active )54.8 (AOSD the rapid)]TJ
-0.0002 Tc -0.00169 Tw T*
(synthesis of ferritin exceeds the rate of iron incorporation in)Tj
-0.00011 Tc 0.3432 Tw T*
[(ferritin. )17.8 (This is in support of our working hypothesis.)]TJ
0 Tc 0.02499 Tw T*
(Further investigations are needed to prove the mechanism.)Tj
-0.00011 Tc 0.1949 Tw 27.6 63.9 Td
[(W)79.7 (e suggest that for clinical practice serum transferrin)]TJ
0 Tc 0.11951 Tw -1.2 -1.2 Td
(receptor determination is to be preferred for estimation of)Tj
0.0809 Tw T*
(the iron stores in acute phase conditions. Determination of)Tj
0.06219 Tw T*
(the iron saturation of ferritin may be of value for scientific)Tj
0.0502 Tw T*
(purposes, but this method is not advocated in clinical prac-)Tj
0 Tw T*
(tice.)Tj
/TT1 1 Tf
-0.00011 Tc 0 -2.4 TD
(REFERENCES)Tj
/TT0 1 Tf
0.02499 Tw 8 0 0 8 325 619.1616 Tm
[(1.)-875.1 (Bywaters EG. Still\222)54.8 (s disease in the adult. )54.8 (Ann Rheum Dis)]TJ
0 Tc 0 Tw 1.675 -1.25 Td
(1971;30:121-33.)Tj
0.0249 Tw -1.675 -1.25 Td
[(2.)-875 (Ohta )54.8 (A, )36.8 (Y)100.1 (amaguchi M, Kaneoka H, Nagayoshi )17.7 (T)74 (,)0.1 ( Hiida M. )54.8 (Adult)]TJ
-0.00011 Tc 1.675 -1.25 Td
[(Still\222)54.8 (s disease: review of 228 cases from the literature. J Rheumatol)]TJ
0 Tc 0 Tw 0 -1.25 TD
[(1987;14:1)36.9 (139-46.)]TJ
0.0249 Tw -1.675 -1.25 Td
[(3.)-875 (V)111.1 (an Reeth C, Le Mo\353l G, Lasne )36.8 (Y)129.2 (, Revenant MC, )54.8 (Agneray J, Kahn)]TJ
-0.00011 Tc 1.675 -1.25 Td
[(MF)79.7 (, Bour)17.7 (geois P)110.7 (. Serum ferritin and isoferritins are tools for)]TJ
0 Tc T*
[(diagnosis of active Still\222)54.9 (s disease. J Rheumatol 1994;21:890-5.)]TJ
-1.675 -1.25 Td
[(4.)-875 (Hoshino )17.8 (T)74 (, Ohta )54.9 (A, )36.9 (Y)100.1 (ang D, et al. Elevated serum interleukin 6,)]TJ
-0.00011 Tc 1.675 -1.25 Td
[(interferon-gamma and tumor necrosis factor)19.7 (-alpha levels in patients)]TJ
0 Tc T*
[(with adult Still\222)54.9 (s disease. J Rheumatol 1998;25:396-8.)]TJ
-0.00011 Tc -1.675 -1.25 Td
[(5.)-875.1 (Cof)17.7 (fernils M, Soupart )54.8 (A, Pradier O, Feremans )17.7 (W)91.7 (, Neve P)110.7 (,)-0.1 ( Decaux)]TJ
1.675 -1.25 Td
[(G. Hyperferritinemia in adult onset Still\222)54.8 (s disease and the)]TJ
0 Tc T*
(hemophagocytic syndrome. J Rheumatol 1992;19:1425-7.)Tj
-0.00011 Tc -1.675 -1.25 Td
[(6.)-875.1 (W)39.7 (itte DL, )54.8 (Angstadt DS, Davis SH, Schrantz RD. Predicting bone)]TJ
0 Tc 1.675 -1.25 Td
(marrow iron stores in anemic patients in a community hospital)Tj
T*
[(using ferritin and erythrocyte sedimentation rate. )54.8 (Am J Clin Pathol)]TJ
0 Tw T*
(1988;90:85-7.)Tj
0.0249 Tw -1.675 -1.25 Td
[(7.)-875 (Coenen JLLM, van Dieijen-V)59.8 (isser MP)110.8 (, van Pelt J, et al.)]TJ
-0.00011 Tc 1.675 -1.25 Td
(Measurement of serum ferritin used to predict concentrations of)Tj
0 Tc T*
(iron in bone marrow in anemia of chronic disease. Clin Chem)Tj
0 Tw T*
(1991;37:560-3.)Tj
0.0249 Tw -1.675 -1.25 Td
[(8.)-875 (ten Kate J, )17.7 (W)79.8 (olthuis )54.8 (A, )17.7 (W)79.8 (esterhuis B, van Deursen C. )17.7 (The iron)]TJ
1.675 -1.25 Td
(content of serum ferritin: Physiological importance and diagnostic)Tj
T*
(value. Eur J Clin Chem Clin Biochem 1997;35:53-6.)Tj
-0.00011 Tc -1.675 -1.25 Td
[(9.)-875.1 (V)111 (ernet M, Doyen C. )54.8 (Assessment of iron status with a new fully)]TJ
1.675 -1.25 Td
(automated assay for transferrin receptor in human serum. Clin)Tj
0 Tc T*
(Chem Lab Med 2000;38:437-42.)Tj
-0.00011 Tc -2.175 -1.25 Td
[(10.)-875.1 (Y)100 (amaguchi M, Ohta )54.8 (A, )17.7 (T)69.7 (sunematsu )17.7 (T)73.9 (, et al. Preliminary criteria for)]TJ
0 Tc 2.175 -1.25 Td
[(classification of adult Still\222)54.9 (s disease. J Rheumatol 1992;19:424-30.)]TJ
-0.00011 Tc -2.1381 -1.25 Td
[(1)36.8 (1)-0.1 (.)-875.1 (ten Kate J, Marell K, Huizinga R, Kreeftenber)17.7 (g H, van Deursen C.)]TJ
0 Tc 2.1381 -1.25 Td
(Iron saturation of ferritin in the course of phlebotomy treatment in)Tj
T*
(patients with haemochromatosis. Clin Chem Lab Med 1999;)Tj
0 Tw T*
(37:827-30.)Tj
-0.00011 Tc 0.02499 Tw -2.175 -1.25 Td
[(12.)-875.1 (W)79.7 (orwood M, Dawkins S, )17.7 (W)79.7 (agstaf)17.7 (f M, Jacobs )54.8 (A. )17.7 (The purification)]TJ
2.175 -1.25 Td
(and properties of ferritin from human serum. Biochem J)Tj
0 Tc 0 Tw T*
(1976;157:97-103.)Tj
-0.00011 Tc 0.02499 Tw -2.175 -1.25 Td
[(13.)-875.1 (Herbert )17.7 (V)129.1 (,)-0.1 ( Shaw S, Jayatilleke E. High serum ferritin protein does)]TJ
0 Tc 2.175 -1.25 Td
[(not distinguish iron overload from inflammation, but a new assay)64.9 (,)]TJ
-0.00011 Tc T*
[(high serum ferritin iron, does. )54.8 (Am J Clin Nutr 1995;61:91)36.8 (1.)]TJ
0 Tc -2.175 -1.25 Td
[(14.)-875 (Pinero DJ, Hu J, Cook BM, Scaduto RC, Conno JR. Interleukin-)]TJ
2.175 -1.25 Td
(1beta increases binding of iron regulatory protein and the synthesis)Tj
T*
[(of ferritin by increasing the labile iron pool. Biochem Biophys )54.9 (Acta)]TJ
0 Tw T*
(2000;1497:279-88.)Tj
-0.00011 Tc 0.02499 Tw -2.175 -1.25 Td
[(15.)-875.1 (Skikne BS, Flowers CH, Cook JD. Serum transferrin receptor: a)]TJ
0 Tc 2.175 -1.25 Td
[(quantitative measure of tissue iron deficiency)64.9 (. Blood 1990;)]TJ
0 Tw T*
(75:1870-6.)Tj
0.0249 Tw -2.175 -1.25 Td
[(16.)-875 (Meyron-Holtz EG, Fibach E, Gelvan D, Konijn )54.8 (AM. Binding and)]TJ
2.175 -1.25 Td
(uptake of exogenous isoferritins by human cultured erythroid)Tj
T*
(precursor cells. Br J Haematol 1994;86:635-41.)Tj
-2.175 -1.25 Td
[(17.)-875 (V)60.1 (ignes S, Le Moel G, Fautrel B, )17.7 (W)79.8 (echsler B, Godeau P)110.8 (,)0.1 ( Piette J-C.)]TJ
2.175 -1.25 Td
(Percentage of glycosylated serum ferritin remains low throughout)Tj
T*
[(the course of adult onset Still\222)54.9 (s disease. )54.8 (Ann Rheum Dis)]TJ
0 Tw T*
(2000;59:347-50.)Tj
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0.02499 Tw 8 0 0 8 54.5 35.9844 Tm
[(ten Kate, et al: Ir)36.8 (on status in )17.8 (AOSD)]TJ
0 Tw 60.9375 -0.0313 Td
(2215)Tj
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(Personal non-commercial use only. The Journal of Rheumatology Copyright\
\251 2001. All rights reserved.)Tj
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