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Research ArticleArticle

What Affects Care Complexity in Rheumatoid Arthritis? An Integrative Review of Complexity Domains and Associated Patient and Health System Outcomes

Kiran Dhiman, Oscar Russell, Catherine Hill, Alison M. Hoens, Trafford Crump, Saania Zafar, Diane Lacaille, Manuel Ester, Cierra Stiegelmar, Cheryl Barnabe, Monika Szpunar, Melissa Sipley, Steven Katz, Jim Rankin, Glen Hazlewood and Claire E.H. Barber
The Journal of Rheumatology July 2026, jrheum.2026-0088; DOI: https://doi.org/10.3899/jrheum.2026-0088
Kiran Dhiman
K. Dhiman, MPH, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
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  • ORCID record for Kiran Dhiman
Oscar Russell
O. Russell, MBBS, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia.
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  • ORCID record for Oscar Russell
Catherine Hill
C. Hill, MBBS, MD, Faculty of Health and Medical Sciences, University of Adelaide, Adelaide, South Australia, Australia.
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Alison M. Hoens
A.M. Hoens, MSc, BScPT, Arthritis Research Canada, Vancouver, British Columbia; Department of Physical Therapy, University of British Columbia, Vancouver, British Columbia, Canada.
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  • ORCID record for Alison M. Hoens
Trafford Crump
T. Crump, PhD, Department of Surgery, Faculty of Medicine and Health Sciences, McGill University, Montreal, Quebec; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
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Saania Zafar
S. Zafar, MSc, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
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Diane Lacaille
D. Lacaille, MDCM, MHSc, Arthritis Research Canada, Vancouver, British Columbia; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
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Manuel Ester
M. Ester, PhD, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
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  • ORCID record for Manuel Ester
Cierra Stiegelmar
C. Stiegelmar, MD, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
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Cheryl Barnabe
C. Barnabe, MD, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta; Arthritis Research Canada, Vancouver, British Columbia; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary; McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
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Monika Szpunar
M. Szpunar, PhD, Arthritis Research Canada, Vancouver, British Columbia, Canada.
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Melissa Sipley
M. Sipley, MSc, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
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Steven Katz
S. Katz, MD, Division of Rheumatology, University of Alberta, Edmonton, Alberta, Canada.
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Jim Rankin
J. Rankin, RN, ACNP, PhD, Faculty of Nursing, University of Calgary, Calgary, Alberta, Canada.
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Glen Hazlewood
G. Hazlewood, MD, PhD, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta; Arthritis Research Canada, Vancouver, British Columbia; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary; McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
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Claire E.H. Barber
C.E.H. Barber, MD, PhD, Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Alberta; Arthritis Research Canada, Vancouver, British Columbia; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary; McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.
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Abstract

Objective Care complexity represents the intersection of health status and social determinants of health, which can affect patient care and outcomes. People living with rheumatoid arthritis (RA) experiencing care complexity may require longer healthcare appointments or more frequent healthcare visits or services. This review identified RA-related care complexity domains and their associated patient outcomes.

Methods An integrative literature review was conducted to identify RA-related care complexity domains and their associated patient, provider, and health system outcomes across diverse study designs. MEDLINE was searched using keywords and Medical Subject Headings (MeSH) terms for care complexity domains and outcomes from 2000 to present. Extracted data were analyzed using the constant comparison method.

Results The search yielded 9835 articles, and 181 met the inclusion criteria. The care complexity domains identified included comorbidity/multimorbidity and polypharmacy, overweight/obesity, substance use, mental health, chronic pain, difficult-to-treat RA, cognitive impairment, advanced age and/or frailty, race and ethnicity, socioeconomic considerations, social support/connectedness, and healthcare access. The most common outcomes across ≥ 1 of the domains were impaired functional status, poor quality of life, elevated mortality risk, high disease activity and/or difficulty achieving remission, and higher healthcare utilization. Intersectionality between domains compounded the effect on outcomes. Evidence was unevenly distributed, with relatively few studies examining outcomes of care complexity at the health system level.

Conclusion We identified 12 domains of care complexity and 5 patient outcomes. Our findings will inform the development of a care complexity framework and measurement strategies to tailor care to patient needs.

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The Journal of Rheumatology: 53 (9)
The Journal of Rheumatology
Vol. 53, Issue 9
1 Sep 2026
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What Affects Care Complexity in Rheumatoid Arthritis? An Integrative Review of Complexity Domains and Associated Patient and Health System Outcomes
Kiran Dhiman, Oscar Russell, Catherine Hill, Alison M. Hoens, Trafford Crump, Saania Zafar, Diane Lacaille, Manuel Ester, Cierra Stiegelmar, Cheryl Barnabe, Monika Szpunar, Melissa Sipley, Steven Katz, Jim Rankin, Glen Hazlewood, Claire E.H. Barber
The Journal of Rheumatology Jul 2026, jrheum.2026-0088; DOI: 10.3899/jrheum.2026-0088

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What Affects Care Complexity in Rheumatoid Arthritis? An Integrative Review of Complexity Domains and Associated Patient and Health System Outcomes
Kiran Dhiman, Oscar Russell, Catherine Hill, Alison M. Hoens, Trafford Crump, Saania Zafar, Diane Lacaille, Manuel Ester, Cierra Stiegelmar, Cheryl Barnabe, Monika Szpunar, Melissa Sipley, Steven Katz, Jim Rankin, Glen Hazlewood, Claire E.H. Barber
The Journal of Rheumatology Jul 2026, jrheum.2026-0088; DOI: 10.3899/jrheum.2026-0088
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