Hepatic Involvement in Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome: Clinical and Therapeutic Insights From 2 Cases

Stefano Romano; Maria Vincenza Mastrolia; Claudia Bracaglia; Francesca Minoia; Teresa Giani; Ivan Caiello; Ilaria Maccora; Martina Rossano; Valerio Maniscalco; Edoardo Marrani; Ilaria Pagnini; Gabriele Simonini

doi:10.3899/jrheum.2026-0131

LetterLetter

Hepatic Involvement in Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome: Clinical and Therapeutic Insights From 2 Cases

Stefano Romano, Maria Vincenza Mastrolia, Claudia Bracaglia, Francesca Minoia, Teresa Giani, Ivan Caiello, Ilaria Maccora, Martina Rossano, Valerio Maniscalco, Edoardo Marrani, Ilaria Pagnini and Gabriele Simonini

The Journal of Rheumatology July 2026, jrheum.2026-0131; DOI: https://doi.org/10.3899/jrheum.2026-0131

Stefano Romano

S. Romano, MD, Rheumatology Unit, ERN ReCONNET Center, Meyer Children's Hospital IRCCS, Florence; Department of Pediatrics, School of Human Health Science, University of Florence, Florence, Italy.

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Maria Vincenza Mastrolia

M.V. Mastrolia, MD, Rheumatology Unit, ERN ReCONNET Center, Meyer Children's Hospital IRCCS, Florence; Neurofarba Department, University of Florence, Florence, Italy.

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Claudia Bracaglia

C. Bracaglia, MD, Division of Rheumatology, ERN RITA Center, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.

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Francesca Minoia

F. Minoia, MD, Pediatric Immunorheumatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

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Teresa Giani

T. Giani, MD, PhD, Rheumatology Unit, ERN ReCONNET Center, Meyer Children's Hospital IRCCS, Florence, Italy.

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Ivan Caiello

I. Caiello, MSc, Laboratory of Immuno-Rheumatology, IRCCS Ospedale Pediatrico Bambino Gesù, Rome, Italy.

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Ilaria Maccora

I. Maccora, MD, PhD, Rheumatology Unit, ERN ReCONNET Center, Meyer Children's Hospital IRCCS, Florence, Italy.

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Martina Rossano

M. Rossano, MD, Pediatric Immunorheumatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

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Valerio Maniscalco

V. Maniscalco, MD, Rheumatology Unit, ERN ReCONNET Center, Meyer Children's Hospital IRCCS, Florence, Italy.

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Edoardo Marrani

E. Marrani, MD, Rheumatology Unit, ERN ReCONNET Center, Meyer Children's Hospital IRCCS, Florence, Italy.

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Ilaria Pagnini

I. Pagnini, MD, PhD, Rheumatology Unit, ERN ReCONNET Center, Meyer Children's Hospital IRCCS, Florence, Italy.

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Gabriele Simonini

G. Simonini, MD, Rheumatology Unit, ERN ReCONNET Center, Meyer Children's Hospital IRCCS, Florence; Neurofarba Department, University of Florence, Florence, Italy.

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The Journal of Rheumatology

Vol. 53, Issue 10

1 Oct 2026

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Hepatic Involvement in Systemic Juvenile Idiopathic Arthritis and Macrophage Activation Syndrome: Clinical and Therapeutic Insights From 2 Cases