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Dr. Harama et al reply

Kimie Harama, Takao Sugiyama, Chisaki Ito, Toyohiko Sugimoto, Soichiro Kubota, Ryosuke Ito, Yoshiaki Kobayashi, Shunichiro Hanai and Daiki Nakagomi
The Journal of Rheumatology November 2025, jrheum.2025-1067; DOI: https://doi.org/10.3899/jrheum.2025-1067
Kimie Harama
K. Harama, MD, Department of Rheumatology, University of Yamanashi Hospital, Yamanashi, Japan; Department of Rheumatology, National Hospital Organization, Shimoshizu Hospital, Yotsukaido, Japan.
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Takao Sugiyama
T. Sugiyama, MD, PhD, Department of Rheumatology, National Hospital Organization, Shimoshizu Hospital, Yotsukaido, Japan.
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Chisaki Ito
C. Ito, MD, Department of Rheumatology, University of Yamanashi Hospital, Yamanashi, Japan; Department of Rheumatology, National Hospital Organization, Shimoshizu Hospital, Yotsukaido, Japan.
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Toyohiko Sugimoto
T. Sugimoto, MD, Department of Rheumatology, National Hospital Organization, Shimoshizu Hospital, Yotsukaido, Japan.
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Soichiro Kubota
S. Kubota, MD, Department of Rheumatology, University of Yamanashi Hospital, Yamanashi, Japan.
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  • ORCID record for Soichiro Kubota
Ryosuke Ito
R. Ito, MD, Department of Rheumatology, University of Yamanashi Hospital, Yamanashi, Japan.
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Yoshiaki Kobayashi
Y. Kobayashi, MD, Department of Rheumatology, University of Yamanashi Hospital, Yamanashi, Japan.
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Shunichiro Hanai
S. Hanai, MD, PhD, Department of Rheumatology, University of Yamanashi Hospital, Yamanashi, Japan; Kasugai Dermatology and Rheumatology Clinic, Kasugai, Japan.
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Daiki Nakagomi
D. Nakagomi, MD, PhD, Department of Rheumatology, University of Yamanashi Hospital, Yamanashi, Japan; Kasugai Dermatology and Rheumatology Clinic, Kasugai, Japan.
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Abstract

We sincerely appreciate the thoughtful comments from Drs. Ginsberg and Rosner regarding our recent article on the efficacy of tumor necrosis factor (TNF) inhibitors for refractory leg ulcers in cutaneous polyarteritis nodosa (PAN).1 We are pleased to learn that their previously published experience with infliximab therapy in refractory systemic PAN yielded results consistent with our observations in patients with cutaneous-limited disease.2

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The Journal of Rheumatology: 53 (1)
The Journal of Rheumatology
Vol. 53, Issue 1
1 Jan 2026
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Dr. Harama et al reply
Kimie Harama, Takao Sugiyama, Chisaki Ito, Toyohiko Sugimoto, Soichiro Kubota, Ryosuke Ito, Yoshiaki Kobayashi, Shunichiro Hanai, Daiki Nakagomi
The Journal of Rheumatology Nov 2025, jrheum.2025-1067; DOI: 10.3899/jrheum.2025-1067

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Dr. Harama et al reply
Kimie Harama, Takao Sugiyama, Chisaki Ito, Toyohiko Sugimoto, Soichiro Kubota, Ryosuke Ito, Yoshiaki Kobayashi, Shunichiro Hanai, Daiki Nakagomi
The Journal of Rheumatology Nov 2025, jrheum.2025-1067; DOI: 10.3899/jrheum.2025-1067
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  • Smoking Cessation and Gout Risk in Indigenous Populations: A Call for Causal Inference and Multiethnic Mendelian Randomization
  • Promising Imaging Methods for Assessment of Structural Progression in Axial Spondyloarthritis
  • Tumor Necrosis Factor Inhibitor Therapy in Polyarteritis Nodosa: Expanding Evidence From Systemic to Cutaneous Disease
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