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Research ArticleImages in Rheumatology

An Uncommon Case of Cerebellar Leukoencephalopathy Secondary to Low-Dose Methotrexate

Dana Y.L. Lee, Sharmayne R.E. Brady and Tai-Juan Aw
The Journal of Rheumatology November 2025, jrheum.2025-0776; DOI: https://doi.org/10.3899/jrheum.2025-0776
Dana Y.L. Lee
D.Y.L. Lee, BMedSc/MD, School of Translational Medicine, Monash University, Melbourne; Department of Rheumatology, Alfred Health, Melbourne, Victoria, Australia.
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Sharmayne R.E. Brady
S.R.E. Brady, MBBS (Hons), PhD, Department of Rheumatology, Alfred Health, Melbourne; Arthritis and Rheumatology Centre, Endeavour Hills, Victoria, Australia.
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Tai-Juan Aw
T.J. Aw, MBBS, Department of Rheumatology, Alfred Health, Melbourne, Victoria; Peninsula Rheumatology, Langwarrin, Victoria, Australia.
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Abstract

Methotrexate (MTX) is a commonly used disease-modifying antirheumatic drug in the treatment of rheumatoid arthritis (RA). MTX neurotoxicity in an RA population is uncommon, with few case reports describing this phenomenon.1-3

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The Journal of Rheumatology: 52 (12)
The Journal of Rheumatology
Vol. 52, Issue 12
1 Dec 2025
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An Uncommon Case of Cerebellar Leukoencephalopathy Secondary to Low-Dose Methotrexate
Dana Y.L. Lee, Sharmayne R.E. Brady, Tai-Juan Aw
The Journal of Rheumatology Nov 2025, jrheum.2025-0776; DOI: 10.3899/jrheum.2025-0776

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An Uncommon Case of Cerebellar Leukoencephalopathy Secondary to Low-Dose Methotrexate
Dana Y.L. Lee, Sharmayne R.E. Brady, Tai-Juan Aw
The Journal of Rheumatology Nov 2025, jrheum.2025-0776; DOI: 10.3899/jrheum.2025-0776
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