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LetterResearch Letter

Anifrolumab in Systemic Lupus Erythematosus With Severe Hematological Manifestations: A Spanish Multicenter Study

Adrián Mayo-Juanatey, Santos Castañeda, Vanesa Calvo-Río, Marta Garijo-Bufort, Miriam Retuerto-Guerrero, Marina Salido Olivares and Juan José Alegre-Sancho
The Journal of Rheumatology October 2025, jrheum.2025-0658; DOI: https://doi.org/10.3899/jrheum.2025-0658
Adrián Mayo-Juanatey
A. Mayo-Juanatey, MD, Department of Rheumatology, Hospital Universitari Doctor Peset, Valencia.
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Santos Castañeda
S. Castañeda, MD, PhD, Department of Rheumatology, Hospital Universitario de la Princesa, IIS-Princesa, Madrid.
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Vanesa Calvo-Río
V. Calvo-Río, MD, PhD, Department of Rheumatology, Hospital Universitario Marqués de Valdecilla, Santander.
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Marta Garijo-Bufort
M. Garijo-Bufort, MD, PhD, Department of Rheumatology, Hospital de Sagunto, Sagunto, Valencia.
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Miriam Retuerto-Guerrero
M. Retuerto-Guerrero, MD, PhD, Department of Rheumatology, Complejo Asistencial Universitario de León, León.
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Marina Salido Olivares
M. Salido Olivares, MD, PhD, Department of Rheumatology, Hospital Universitario Infanta Cristina, Parla, Madrid, Spain.
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Juan José Alegre-Sancho
J.J. Alegre-Sancho, MD, PhD, Department of Rheumatology, Hospital Universitari Doctor Peset, Valencia.
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This article has a correction. Please see:

  • Errata - November 05, 2025

Abstract

Anifrolumab (ANI) is a monoclonal antibody targeting the interferon alpha receptor 1 (IFNAR1), used in patients with systemic lupus erythematosus (SLE). It has demonstrated particular efficacy in the cutaneous and musculoskeletal domains of SLE,1,2 leading to its inclusion in the 2023 European Alliance of Associations for Rheumatology (EULAR) SLE treatment recommendations as an effective drug to control SLE flares and taper prednisone dose.3

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The Journal of Rheumatology: 52 (11)
The Journal of Rheumatology
Vol. 52, Issue 11
1 Nov 2025
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Anifrolumab in Systemic Lupus Erythematosus With Severe Hematological Manifestations: A Spanish Multicenter Study
Adrián Mayo-Juanatey, Santos Castañeda, Vanesa Calvo-Río, Marta Garijo-Bufort, Miriam Retuerto-Guerrero, Marina Salido Olivares, Juan José Alegre-Sancho
The Journal of Rheumatology Oct 2025, jrheum.2025-0658; DOI: 10.3899/jrheum.2025-0658

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Anifrolumab in Systemic Lupus Erythematosus With Severe Hematological Manifestations: A Spanish Multicenter Study
Adrián Mayo-Juanatey, Santos Castañeda, Vanesa Calvo-Río, Marta Garijo-Bufort, Miriam Retuerto-Guerrero, Marina Salido Olivares, Juan José Alegre-Sancho
The Journal of Rheumatology Oct 2025, jrheum.2025-0658; DOI: 10.3899/jrheum.2025-0658
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