Quality of Life in Adult Patients With SAPHO Syndrome and Chronic Nonbacterial Osteomyelitis, and Comparison to Chronic Rheumatic and Inflammatory Diseases

A. Lenert, MD, MS, Division of Immunology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
J. Thomason, MD, MPH, Division of Rheumatology, University of Washington, Rheumatology Clinic at Harborview, Seattle, Washington, USA.
M.H. Smith, MD, PhD, Weill Cornell Medicine, Hospital for Special Surgery, New York, New York, USA.
H. Abodeely, Division of Immunology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
S.D. Hong, MD, Division of Pediatric Rheumatology, University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, USA.
C.E. Kremer, ARNP, Division of Pediatric Rheumatology, University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, USA.
P.S. Lenert, MD, PhD, Division of Immunology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.
T.S. Sato, MD, Department of Radiology, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.
S. Hansmann, MD, Department of Pediatrics, Division of Pediatric Rheumatology and autoinflammation reference center Tübingen (arcT), University Hospital Tübingen, Tübingen, Germany.
M. Oliver, MD, Division of Pediatric Rheumatology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Y. Zhao, MD, PhD, Division of Pediatric Rheumatology, Department of Pediatrics, University of Washington School of Medicine, Seattle Children's Hospital, Seattle, Washington, USA.
J. Templin, PhD, Department of Psychological and Quantitative Foundations, College of Education, University of Iowa, Iowa City, Iowa, USA.
M. Vaughan-Sarrazin, PhD, Department of Internal Medicine, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
R. Domsic, MD, MPH, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
D.H. Solomon, MD, MPH, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
P.J. Ferguson, MD, Division of Pediatric Rheumatology, Carver College of Medicine, University of Iowa Stead Family Children's Hospital, Iowa City, Iowa, USA.

CONTRIBUTIONS: Conceptualization, methodology, formal analysis, investigation, writing (original draft), writing (review and editing), funding acquisition: AL. Conceptualization, methodology, investigation, writing (review and editing), funding acquisition: PJF. Conceptualization, methodology, writing (review and editing): JoT, MVS, RD, DHS. Investigation, writing (review and editing): JeT, MHS, HA, SDH, CEK, PSL, TSS, SH, MO, YZ. All authors critically reviewed and approved the final version.
FUNDING: This work was funded by the National Institutes of Health (NIH; no. K23 AR082966 [AL], no. P50 AR080612 [RD], no. P30 AR072577 [DHS], no. UM1TR004403 [University of Iowa]).
COMPETING INTERESTS: DHS has received research contracts unrelated to the current study from Amgen, CorEvitas, and Janssen, and he also receives royalties from unrelated chapters in UpToDate. The remaining authors declare no conflicts of interest relevant to this article.
ETHICS AND PATIENT CONSENT: This study has received approval from the University of Iowa institutional review board (IRB; no. 202107229) through the single-site IRB (SMART IRB) reliance mechanism required by the NIH. We obtained written informed consent from all subjects enrolled in this study.
SUPPLEMENTARY DATA: Supplementary material accompanies the online version of this article.
Accepted for publication July 9, 2025.

Address correspondence to Dr. A. Lenert, Division of Immunology, Department of Internal Medicine, Carver College of Medicine, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA. Email: aleksander-lenert{at}uiowa.edu.