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Research ArticleArticle

Degenerative Disc Disease in Young Adults With Psoriatic Arthritis

Fadi Kharouf, Shangyi Gao, Daniel Pereira, Richard J. Cook, Vinod Chandran and Dafna D. Gladman
The Journal of Rheumatology February 2025, jrheum.2024-1148; DOI: https://doi.org/10.3899/jrheum.2024-1148
Fadi Kharouf
F. Kharouf, MD, Gladman-Krembil Psoriatic Arthritis Research Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, and Division of Rheumatology, Department of Medicine, University of Toronto, Toronto.
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  • ORCID record for Fadi Kharouf
Shangyi Gao
S. Gao, MSc, Gladman-Krembil Psoriatic Arthritis Research Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto.
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Daniel Pereira
D. Pereira, BSc, Gladman-Krembil Psoriatic Arthritis Research Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto.
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Richard J. Cook
R.J. Cook, MMath, PhD, Department of Statistics and Actuarial Science, University of Waterloo, Waterloo.
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Vinod Chandran
V. Chandran, MBBS, MD, DM, PhD, Gladman-Krembil Psoriatic Arthritis Research Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, and Division of Rheumatology, Department of Medicine, University of Toronto, and Institute of Medical Science, University of Toronto, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario.
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Dafna D. Gladman
D.D. Gladman, MD, Gladman-Krembil Psoriatic Arthritis Research Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, and Division of Rheumatology, Department of Medicine, University of Toronto, and Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
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Article Information

jrheum.2024-1148
DOI 
https://doi.org/10.3899/jrheum.2024-1148
PubMed 
39955091

Published By 
The Journal of Rheumatology
Print ISSN 
0315-162X
Online ISSN 
1499-2752
History 
  • Published online March 15, 2025.

Article Versions

  • Latest version (February 15, 2025 - 04:00).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2024 The Journal of Rheumatology

Author Information

  1. Fadi Kharouf,
  2. Shangyi Gao,
  3. Daniel Pereira,
  4. Richard J. Cook,
  5. Vinod Chandran and
  6. Dafna D. Gladman
  1. F. Kharouf, MD, Gladman-Krembil Psoriatic Arthritis Research Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, and Division of Rheumatology, Department of Medicine, University of Toronto, Toronto.
  2. S. Gao, MSc, Gladman-Krembil Psoriatic Arthritis Research Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto.
  3. D. Pereira, BSc, Gladman-Krembil Psoriatic Arthritis Research Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto.
  4. R.J. Cook, MMath, PhD, Department of Statistics and Actuarial Science, University of Waterloo, Waterloo.
  5. V. Chandran, MBBS, MD, DM, PhD, Gladman-Krembil Psoriatic Arthritis Research Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, and Division of Rheumatology, Department of Medicine, University of Toronto, and Institute of Medical Science, University of Toronto, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario.
  6. D.D. Gladman, MD, Gladman-Krembil Psoriatic Arthritis Research Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, and Division of Rheumatology, Department of Medicine, University of Toronto, and Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
  1. CONTRIBUTIONS: FK: conceptualization, data curation, formal analysis, investigation, methodology, project administration, validation, visualization, writing – original draft, writing – review & editing; SG: conceptualization, data curation, formal analysis, investigation, methodology, resources, software, validation, visualization, writing – original draft, writing – review & editing; DP: data curation, investigation, project administration, resources, software, supervision, validation, visualization, writing – review & editing; RJC: conceptualization, data curation, formal analysis, project administration, investigation, methodology, resources, software, supervision, validation, visualization, writing – review & editing; VC, DDG: conceptualization, data curation, formal analysis, funding acquisition, investigation, methodology, project administration, resources, software, supervision, validation, visualization, writing – original draft, writing – review & editing.
    FUNDING: The Gladman-Krembil Psoriatic Arthritis Research Program is funded by the Krembil Foundation and the Schroeder Arthritis Institute. VC is supported by a clinician scientist salary award from the Department of Medicine, University of Toronto.
    COMPETING INTERESTS: VC has received research grants from AbbVie, Amgen, and Eli Lilly, and has received honoraria for advisory board member roles from AbbVie, BMS, Eli Lilly, Fresenius Kabi, Janssen, Novartis, and UCB; and his spouse is an employee of AstraZeneca. DDG has received grants and/or consulting fees from AbbVie, Amgen, AstraZeneca, BMS, Eli Lilly, Janssen, Novartis, Pfizer, and UCB. FK, SG, DP, and RJC declare no conflicts of interest relevant to this article.
    ETHICS AND PATIENT CONSENT: We obtained ethics review and approval from the University Health Network Research Ethics Board (08-0630). We collected informed consent from all patients at enrollment.
    Accepted for publication January 28, 2025.
  1. Address correspondence to Dr. D.D. Gladman, Gladman-Krembil Psoriatic Arthritis Research Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute; Krembil Research Institute, University Health Network, 399 Bathurst Street 14MC409C, Toronto, ON M5T 2S8, Canada. Email: dafna.gladman@utoronto.ca.

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Degenerative Disc Disease in Young Adults With Psoriatic Arthritis
Fadi Kharouf, Shangyi Gao, Daniel Pereira, Richard J. Cook, Vinod Chandran, Dafna D. Gladman
The Journal of Rheumatology Feb 2025, jrheum.2024-1148; DOI: 10.3899/jrheum.2024-1148

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Degenerative Disc Disease in Young Adults With Psoriatic Arthritis
Fadi Kharouf, Shangyi Gao, Daniel Pereira, Richard J. Cook, Vinod Chandran, Dafna D. Gladman
The Journal of Rheumatology Feb 2025, jrheum.2024-1148; DOI: 10.3899/jrheum.2024-1148
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