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Research ArticleArticle

Degenerative Disc Disease in Young Adults With Psoriatic Arthritis

Fadi Kharouf, Shangyi Gao, Daniel Pereira, Richard J. Cook, Vinod Chandran and Dafna D. Gladman
The Journal of Rheumatology February 2025, jrheum.2024-1148; DOI: https://doi.org/10.3899/jrheum.2024-1148
Fadi Kharouf
F. Kharouf, MD, Gladman-Krembil Psoriatic Arthritis Research Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, and Division of Rheumatology, Department of Medicine, University of Toronto, Toronto.
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Shangyi Gao
S. Gao, MSc, Gladman-Krembil Psoriatic Arthritis Research Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto.
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Daniel Pereira
D. Pereira, BSc, Gladman-Krembil Psoriatic Arthritis Research Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto.
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Richard J. Cook
R.J. Cook, MMath, PhD, Department of Statistics and Actuarial Science, University of Waterloo, Waterloo.
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Vinod Chandran
V. Chandran, MBBS, MD, DM, PhD, Gladman-Krembil Psoriatic Arthritis Research Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, and Division of Rheumatology, Department of Medicine, University of Toronto, and Institute of Medical Science, University of Toronto, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario.
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Dafna D. Gladman
D.D. Gladman, MD, Gladman-Krembil Psoriatic Arthritis Research Program, Centre for Prognosis Studies in the Rheumatic Diseases, Schroeder Arthritis Institute, Krembil Research Institute, University Health Network, Toronto, and Division of Rheumatology, Department of Medicine, University of Toronto, and Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
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Abstract

Objective We aimed to explore the prevalence of degenerative disc disease (DDD) in patients with psoriatic arthritis (PsA) aged < 50 years and to describe the factors associated with its development. We also examined the association between radiographic axial imaging findings and inflammatory back pain (IBP) and mechanical back pain.

Methods We included patients with PsA aged < 50 years who were followed at our prospective observational cohort. We defined DDD as intervertebral disc space narrowing, spur formation, facet joint arthrosis, and spondylolisthesis on anteroposterior and lateral plain radiographs of the cervical and thoracolumbar spine. To identify factors associated with the development of DDD, we used multivariate Cox regression analysis. We used generalized estimating equations (GEEs) to test the association between imaging findings (isolated DDD, isolated axial disease, and both) and the type of back pain.

Results Of 814 patients included in the study, 316 (38.8%) were observed to have DDD on plain radiographs of the spine. Factors associated with the development of DDD included older age (hazard ratio [HR] 1.08, P < 0.01), male sex (HR 1.52, P = 0.03), diabetes mellitus (HR 2.35, P = 0.045), and IBP (HR 2.03, P < 0.01). Being employed (vs unemployed), higher BMI, calcaneal spurs, and targeted disease- modifying antirheumatic drug use showed a trending association with DDD. In the GEE analysis, none of the abnormal imaging findings were significantly associated with back pain or IBP.

Conclusion DDD is common in young patients with PsA, and its development may be associated with demographic features, comorbidities, and disease-related factors. IBP does not reliably distinguish between axial PsA and DDD.

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The Journal of Rheumatology
Vol. 52, Issue 5
1 May 2025
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Degenerative Disc Disease in Young Adults With Psoriatic Arthritis
Fadi Kharouf, Shangyi Gao, Daniel Pereira, Richard J. Cook, Vinod Chandran, Dafna D. Gladman
The Journal of Rheumatology Feb 2025, jrheum.2024-1148; DOI: 10.3899/jrheum.2024-1148

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Degenerative Disc Disease in Young Adults With Psoriatic Arthritis
Fadi Kharouf, Shangyi Gao, Daniel Pereira, Richard J. Cook, Vinod Chandran, Dafna D. Gladman
The Journal of Rheumatology Feb 2025, jrheum.2024-1148; DOI: 10.3899/jrheum.2024-1148
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