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Research ArticleAccepted Articles
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Association between abatacept exposure levels and infection occurrence in patients with rheumatoid arthritis: post hoc analysis of the AVERT-2 study

Paul Emery, Roy Fleischmann, Robert Wong, Karissa Lozenski, Yoshiya Tanaka, Vivian P. Bykerk, Clifton O. Bingham 3rd, Thomas W.J. Huizinga, Gustavo Citera, Vidya Perera, Bindu Murthy, Kelly Fellows Maxwell, Julie Passarell, William D Hedrich and Daphne Williams
The Journal of Rheumatology January 2025, jrheum.2024-0498; DOI: https://doi.org/10.3899/jrheum.2024-0498
Paul Emery
Professor Paul Emery, MD, FMedSci, Leeds NIHR Biomedical Research Centre, & Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
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Roy Fleischmann
Professor Roy Fleischmann, MD, University of Texas Southwestern Medical Center, Dallas, TX, USA.
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Robert Wong
Dr Robert Wong, MD, Bristol Myers Squibb, Princeton, NJ, USA (at the time of analysis).
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Karissa Lozenski
Dr Karissa Lozenski, PhD, Bristol Myers Squibb, Princeton, NJ, USA.
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Yoshiya Tanaka
Dr Yoshiya Tanaka, MD, PhD, University of Occupational and Environmental Health – Japan, Kitakyushu, Japan.
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Vivian P. Bykerk
Dr Vivian Bykerk, BSc, MD, FRCPC, Hospital for Special Surgery, New York, NY, USA.
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Clifton O. Bingham 3rd
Dr Clifton O Bingham, 3rd, MD, Johns Hopkins University, Baltimore, MD, USA.
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Thomas W.J. Huizinga
Dr Thomas WJ Huizinga, MD, PhD, Leiden University Medical Center, Leiden, Netherlands.
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Gustavo Citera
Dr Gustavo Citera, MD, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina.
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Vidya Perera
Dr Vidya Perera, PhD, Bristol Myers Squibb, Princeton, NJ, USA.
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Bindu Murthy
Dr Bindu Murthy, PharmD, Bristol Myers Squibb, Princeton, NJ, USA.
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Kelly Fellows Maxwell
Dr Kelly Fellows Maxwell, PhD, Cognigen Corporation, a Simulations Plus company, Buffalo, NY, USA.
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Julie Passarell
Mrs Julie Passarell, MA, Cognigen Division, a Simulations Plus company, Buffalo, NY, USA.
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William D Hedrich
Dr William D Hedrich, PhD, MS, Bristol Myers Squibb, Princeton, NJ, USA (at the time of analysis).
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Daphne Williams
Dr Daphne Williams, PharmD, Bristol Myers Squibb, Princeton, NJ, USA.
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Article Information

jrheum.2024-0498
DOI 
https://doi.org/10.3899/jrheum.2024-0498
PubMed 
39814436

Published By 
The Journal of Rheumatology
Print ISSN 
0315-162X
Online ISSN 
1499-2752
History 
  • Published online January 15, 2025.

Article Versions

  • You are currently viewing a Latest version of this article (January 15, 2025 - 04:00).
  • latest version (March 15, 2025 - 04:00).
  • View the most recent version of this article
Copyright & Usage 
© 2025 The Journal of Rheumatology

Author Information

  1. Paul Emery,
  2. Roy Fleischmann,
  3. Robert Wong,
  4. Karissa Lozenski,
  5. Yoshiya Tanaka,
  6. Vivian P. Bykerk,
  7. Clifton O. Bingham 3rd,
  8. Thomas W.J. Huizinga,
  9. Gustavo Citera,
  10. Vidya Perera,
  11. Bindu Murthy,
  12. Kelly Fellows Maxwell,
  13. Julie Passarell,
  14. William D Hedrich and
  15. Daphne Williams
  1. Professor Paul Emery, MD, FMedSci, Leeds NIHR Biomedical Research Centre, & Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.
  2. Professor Roy Fleischmann, MD, University of Texas Southwestern Medical Center, Dallas, TX, USA.
  3. Dr Robert Wong, MD, Bristol Myers Squibb, Princeton, NJ, USA (at the time of analysis).
  4. Dr Karissa Lozenski, PhD, Bristol Myers Squibb, Princeton, NJ, USA.
  5. Dr Yoshiya Tanaka, MD, PhD, University of Occupational and Environmental Health – Japan, Kitakyushu, Japan.
  6. Dr Vivian Bykerk, BSc, MD, FRCPC, Hospital for Special Surgery, New York, NY, USA.
  7. Dr Clifton O Bingham, 3rd, MD, Johns Hopkins University, Baltimore, MD, USA.
  8. Dr Thomas WJ Huizinga, MD, PhD, Leiden University Medical Center, Leiden, Netherlands.
  9. Dr Gustavo Citera, MD, Instituto de Rehabilitación Psicofísica, Buenos Aires, Argentina.
  10. Dr Vidya Perera, PhD, Bristol Myers Squibb, Princeton, NJ, USA.
  11. Dr Bindu Murthy, PharmD, Bristol Myers Squibb, Princeton, NJ, USA.
  12. Dr Kelly Fellows Maxwell, PhD, Cognigen Corporation, a Simulations Plus company, Buffalo, NY, USA.
  13. Mrs Julie Passarell, MA, Cognigen Division, a Simulations Plus company, Buffalo, NY, USA.
  14. Dr William D Hedrich, PhD, MS, Bristol Myers Squibb, Princeton, NJ, USA (at the time of analysis).
  15. Dr Daphne Williams, PharmD, Bristol Myers Squibb, Princeton, NJ, USA.
  1. CONFLICTS OF INTEREST: PE: consultant: AbbVie, Boehringer Ingelheim, Bristol Myers Squibb, Eli Lilly, Galapagos, Gilead, Janssen, Merck Sharp & Dohme, Novartis, Pfizer, Roche, Samsung; grant/research support: AbbVie, Bristol Myers Squibb, Eli Lilly, Novartis, Pfizer, Roche, Samsung. RF: consultant: Amgen, AbbVie, Arthrosi, Bristol Myers Squibb, Eli Lily, Galapagos, Galvani, Gilead, GlaxoSmithKline, Novartis, Pfizer, Vyne; grant/research support: Amgen, AbbVie, Arthrosi, AstraZeneca, Biosplice, Bristol Myers Squibb, Eli Lilly, Gilead, GlaxoSmithKline, Horizon, Novartis, Pfizer, Regeneron, UCB. RW: shareholder: Bristol Myers Squibb; employee: Bristol Myers Squibb (at the time of analysis). KL, VP, BM: shareholders and employees: Bristol Myers Squibb. YT: speakers bureau: AbbVie, AstraZeneca, Boehringer Ingelheim, Bristol Myers Squibb, Chugai, Daiichi-Sankyo, Eisai, Eli Lilly, Gilead, GlaxoSmithKline, Mitsubishi-Tanabe, Pfizer; grant/research support: AbbVie, Asahi-Kasei, Boehringer-Ingelheim, Chugai, Daiichi-Sankyo, Eisai, Takeda. VB: consultant: AbbVie, Bristol Myers Squibb, Pfizer; grant/research support: Bristol Myers Squibb (to institution). COB: consultant: AbbVie, Bristol Myers Squibb, Eli Lilly, Janssen, Pfizer, Sanofi; grant/research support: Bristol Myers Squibb. TWJH: speakers bureau, consultant, grant/research support: Ablynx, Abbott, Biotest AG, Bristol Myers Squibb, Crescendo Bioscience, Eli Lilly, Epirus, Galapagos, Janssen, Merck, Novartis, Pfizer, Roche, Sanofi-Aventis, UCB. GC: speakers bureau: AbbVie, Amgen, Bristol Myers Squibb, Eli Lilly, Janssen, Pfizer, Sandoz; consultant: AbbVie, Amgen, Bristol Myers Squibb, Pfizer; grant/research support: Pfizer. KFM, JP: consultant: Bristol Myers Squibb; employee: Cognigen Division, a Simulations Plus company. WDH: none declared. DW: consultant: Black Diamond Network, Joule, Syneos; employee: Bristol Myers Squibb.
  1. Correspondence: Professor Paul Emery, MD, FMedSci, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds and Leeds NIHR Biomedical Research Centre, Leeds, UK. Email: P.Emery{at}leeds.ac.uk

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Article usage: January 2025 to October 2025

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Feb 2025255090
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Apr 20251733460
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The Journal of Rheumatology: 52 (11)
The Journal of Rheumatology
Vol. 52, Issue 11
1 Nov 2025
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Accepted manuscript
Association between abatacept exposure levels and infection occurrence in patients with rheumatoid arthritis: post hoc analysis of the AVERT-2 study
Paul Emery, Roy Fleischmann, Robert Wong, Karissa Lozenski, Yoshiya Tanaka, Vivian P. Bykerk, Clifton O. Bingham, Thomas W.J. Huizinga, Gustavo Citera, Vidya Perera, Bindu Murthy, Kelly Fellows Maxwell, Julie Passarell, William D Hedrich, Daphne Williams
The Journal of Rheumatology Jan 2025, jrheum.2024-0498; DOI: 10.3899/jrheum.2024-0498

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Accepted manuscript
Association between abatacept exposure levels and infection occurrence in patients with rheumatoid arthritis: post hoc analysis of the AVERT-2 study
Paul Emery, Roy Fleischmann, Robert Wong, Karissa Lozenski, Yoshiya Tanaka, Vivian P. Bykerk, Clifton O. Bingham, Thomas W.J. Huizinga, Gustavo Citera, Vidya Perera, Bindu Murthy, Kelly Fellows Maxwell, Julie Passarell, William D Hedrich, Daphne Williams
The Journal of Rheumatology Jan 2025, jrheum.2024-0498; DOI: 10.3899/jrheum.2024-0498
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