Abstract
Objective Although patient outcomes in psoriatic arthritis (PsA) have improved with the advent of advanced therapies, there remains a high unmet need to treat residual disease activity. The objective of the current study was to quantify residual disease activity and burden of disease in Canadian patients with PsA.
Methods This was a multi-region, observational, retrospective analysis of patient data extracted from the Rhumadata™ and the International Psoriasis and Arthritis Research Team (IPART) registries, analyzing de-identified data from patients who had initiated advanced therapy for the treatment of PsA between January 2010 and December 2019. The primary endpoint was the proportion of patients failing to achieve minimal disease activity (MDA) within 6 months; secondary endpoints included clinical and patient-reported burden of disease. Descriptive statistics included summaries by region, treatment class, and number of prior advanced therapies.
Results 1,596 patients were included. The proportion of patients who failed to achieve MDA within 6 months of an advanced therapy was 64.8% in Ontario, 68.3% in Western Canada, 74.8% in Québec and 75.0% in the Atlantic/East region. Failure to achieve MDA was higher amongst patients receiving an IL-17i compared with a TNFi in all regions except Atlantic/East. Between 73.2 to 78.6% of patients reported pain at 6 months, and continuing functional impairment varied from 24.0% in the West to 83.3% in the Atlantic/East.
Conclusion There is substantial burden and unmet need for improved therapies for Canadians living with PsA. There is a wide regional variation in outcomes that requires further assessment.
