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LetterLetter

Geographic and Demographic Representation in Industry-Sponsored, US-Based Clinical Trials of Systemic Lupus Erythematosus Therapies

Joshua J. Skydel, Reshma Ramachandran, Sakinah Suttiratana, Joseph S. Ross, Christopher M. Burns and Joshua D. Wallach
The Journal of Rheumatology December 2023, jrheum.2023-0920; DOI: https://doi.org/10.3899/jrheum.2023-0920
Joshua J. Skydel
Joshua J. Skydel, MD, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire.
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Reshma Ramachandran
Reshma Ramachandran, MD, MPP, MHS, Section of General Internal Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, and Yale Collaboration for Regulatory Rigor, Integrity and Transparency, Yale School of Medicine, New Haven, Connecticut, USA.
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Sakinah Suttiratana
Sakinah Suttiratana, PhD, MPH, MBA, Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut.
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Joseph S. Ross
Joseph S. Ross, MD, MHS, Section of General Internal Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, Department of Health Policy and Management, Yale School of Public Health, New Haven, and Yale Collaboration for Regulatory Rigor, Integrity and Transparency, Yale School of Medicine, New Haven, Connecticut.
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Christopher M. Burns
Christopher M. Burns, MD, Section of Rheumatology, Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire.
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Joshua D. Wallach
Joshua D. Wallach, PhD, MS, Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA.
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Abstract

Clinical research into potential therapies for systemic lupus erythematosus (SLE) has increased over the last 2 decades, driven by the discovery of new targetable pathways, yet uncertainty persists over which patients benefit from new therapies.1 Black patients and other minoritized populations, which disproportionately experience severe disease, are underrepresented in SLE trials.2

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The Journal of Rheumatology: 52 (7)
The Journal of Rheumatology
Vol. 52, Issue 7
1 Jul 2025
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Geographic and Demographic Representation in Industry-Sponsored, US-Based Clinical Trials of Systemic Lupus Erythematosus Therapies
Joshua J. Skydel, Reshma Ramachandran, Sakinah Suttiratana, Joseph S. Ross, Christopher M. Burns, Joshua D. Wallach
The Journal of Rheumatology Dec 2023, jrheum.2023-0920; DOI: 10.3899/jrheum.2023-0920

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Geographic and Demographic Representation in Industry-Sponsored, US-Based Clinical Trials of Systemic Lupus Erythematosus Therapies
Joshua J. Skydel, Reshma Ramachandran, Sakinah Suttiratana, Joseph S. Ross, Christopher M. Burns, Joshua D. Wallach
The Journal of Rheumatology Dec 2023, jrheum.2023-0920; DOI: 10.3899/jrheum.2023-0920
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