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Research ArticleArticle

Patient-Reported Outcomes in Calcium Pyrophosphate Deposition Disease Compared to Gout and Osteoarthritis

Mary Grace Whelan, Keigo Hayashi, Hallie Altwies and Sara K. Tedeschi
The Journal of Rheumatology April 2023, jrheum.2023-0031; DOI: https://doi.org/10.3899/jrheum.2023-0031
Mary Grace Whelan
M.G. Whelan, BS, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital.
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Keigo Hayashi
MK. Hayashi, MD, MPH, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital.
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Hallie Altwies
H. Altwies, BS, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital.
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Sara K. Tedeschi
S.K. Tedeschi, MD, MPH, Division of Rheumatology, Inflammation, and Immunity, Brigham and Women's Hospital, and Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
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Abstract

Objective Calcium pyrophosphate deposition (CPPD) disease prevalence is similar to that of gout and osteoarthritis (OA), yet CPPD outcomes research greatly lags behind research in these other forms of arthritis. We compared validated patient-reported outcome measures in patients with CPPD vs gout and OA.

Methods Patients with CPPD were recruited from Brigham and Women's Hospital from 2018 to 2022. Presence of CPPD manifestations (acute calcium pyrophosphate [CPP] crystal arthritis, chronic CPP inflammatory arthritis, and/or OA with CPPD) was confirmed by medical record review. Baseline surveys included the Gout Assessment Questionnaire version 2.0, modified to ask about "pseudogout" rather than "gout"; Routine Assessment of Patient Index Data 3 (RAPID-3); and Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). We compared responses in patients with CPPD against published gout and OA cohort studies.

Results Among 47 patients with CPPD, the mean age was 71.9 years and 51% were female. Sixty-eight percent had at least 1 episode of acute CPP crystal arthritis, 40% had chronic CPP inflammatory arthritis, and 62% had OA with CPPD. Pain visual analog scale scores during a flare were similar in CPPD (mean 6.8 [SD 1.9]) and gout (mean 6.7 [SD 2.6]; P = 0.78). Patients with CPPD reported significantly greater unmet treatment need than patients with gout (P = 0.04). RAPID-3 scores in CPPD (mean 8.1 [SD 5.6]) were lower than in gout (mean 12.1 [SD 6.2]; P < 0.01) and similar in OA (mean 6.8 [SD 6.1]; P = 0.30). Patients with CPPD had significantly worse WOMAC stiffness scores than patients with mild OA, and significantly better WOMAC function scores than patients with severe OA.

Conclusion Patients with CPPD may experience pain comparable to that in gout and OA and reported substantial unmet treatment needs.

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The Journal of Rheumatology
Vol. 50, Issue 9
1 Sep 2023
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Patient-Reported Outcomes in Calcium Pyrophosphate Deposition Disease Compared to Gout and Osteoarthritis
Mary Grace Whelan, Keigo Hayashi, Hallie Altwies, Sara K. Tedeschi
The Journal of Rheumatology Apr 2023, jrheum.2023-0031; DOI: 10.3899/jrheum.2023-0031

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Patient-Reported Outcomes in Calcium Pyrophosphate Deposition Disease Compared to Gout and Osteoarthritis
Mary Grace Whelan, Keigo Hayashi, Hallie Altwies, Sara K. Tedeschi
The Journal of Rheumatology Apr 2023, jrheum.2023-0031; DOI: 10.3899/jrheum.2023-0031
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