Research ArticleAccepted Articles
Traditional and disease specific risk factors for cardiovascular events in ANCA-associated vasculitis: a multinational retrospective study
Sergey Moiseev, Nikolay Bulanov, Matija Crnogorac, Haner Direskeneli, Kresimir Galesic, Ummugulsum Gazel, Duvuru Geetha, Loic Guillevin, Zdenka Hrušková, Mark A. Little, Liam O'Neill, Egor Makarov, Stephen P. McAdoo, Aladdin J. Mohammad, Sarah Moran, Pavel Novikov, Charles D. Pusey, Chinar Rahmattulla, Veronika Satrapová, Joana Silva, Alexander Suvorov, Vladimír Tesar, Benjamin Terrier, Peter Willeit, Ming-Hui Zhao, Andreas Kronbichler and David R. W. Jayne
The Journal of Rheumatology January 2023, jrheum.220851; DOI: https://doi.org/10.3899/jrheum.220851
Sergey Moiseev
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Nikolay Bulanov
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Matija Crnogorac
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Haner Direskeneli
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Kresimir Galesic
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Ummugulsum Gazel
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Duvuru Geetha
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Loic Guillevin
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Zdenka Hrušková
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Mark A. Little
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Liam O'Neill
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Egor Makarov
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Stephen P. McAdoo
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Aladdin J. Mohammad
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Sarah Moran
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Pavel Novikov
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Charles D. Pusey
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Chinar Rahmattulla
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Veronika Satrapová
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Joana Silva
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Alexander Suvorov
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Vladimír Tesar
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Benjamin Terrier
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Peter Willeit
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Ming-Hui Zhao
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Andreas Kronbichler
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
David R. W. Jayne
Tareev Clinic of Internal Diseases, Sechenov First Moscow State Medical University. Faculty of Medicine, Lomonosov Moscow State University, Moscow, Russia. Department of Nephrology and Dialysis, Dubrava University Hospital, Zagreb, Croatia. Department of Internal Medicine, Division of Rheumatology, Marmara University, School of Medicine, Istanbul, Turkey. Division of Nephrology, Department of Medicine, Johns Hopkins University, Baltimore, MD, USA. Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôspital Cochin, Paris, France. Department of Nephrology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. Trinity Health Kidney Centre, Trinity Translational Medicine Institute, Dublin, Ireland. Irish Centre for Vascular Biology, Tallaght University Hospital, Dublin, Ireland. University Hospital Galway, Dublin, Ireland. Department of Immunology and Inflammation , Centre for Inflammatory Disease, Imperial College London, London, UK. Department of Rheumatology, Clinical Sciences-Lund, Lund University, Lund, Sweden. Vasculitis and Lupus Clinic, Addenbrooke's Hospital Cambridge University Hospitals, Cambridge, UK. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands. Centre for Analysis of Complex Systems, Sechenov First Moscow State Medical University, Moscow, Russia. Clinical Epidemiology Team, Medical University of Innsbruck, Innsbruck, Austria. Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. Renal Division, Peking University First Hospital, Key Laboratory of Renal Disease, Ministry of Health of China, Key Laboratory of CKD Prevention and Treatment, Ministry of Education of China, Beijing, China. Department of Medicine, University of Cambridge, Cambridge, UK.
Abstract
Objective To investigate the occurrence of cardiovascular events (CVE) in a large cohort of patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) across the European Union, China, Turkey, Russia, UK, and USA.
Methods Patients with a definite diagnosis of AAV who were followed ≥3 months and had sufficient documentation were included. Data on myocardial infarction (MI) and stroke were collected retrospectively from tertiary vasculitis centers. Univariate and multivariate Cox regression models were used to estimate hazard ratios (HRs) and 95% CIs.
Results Over a median follow-up of 62 (interquartile range: 23, 100) months, CVE (mostly MI) occurred in 245 (10.7%) of 2286 AAV patients with a higher frequency in China and the UK. On multivariate regression analysis, older age (55-64.9 years; HR 2.93, 95% CI: 1.99, 4.31), smoking (HR 1.98, 95% CI: 1.48, 2.64), Chinese origin (HR 4.24, 95% CI: 3.07, 5.85), pulmonary (HR 1.50, 95% CI: 1.09, 2.06) and kidney (HR 3.02, 95% CI: 2.08, 4.37) involvement were independent variables associated with a higher occurrence of CVE.
Conclusion We showed that geographic region and both traditional and disease specific (kidney involvement in particular) factors were independently associated with CVE. Proper assessment and management of modifiable cardiovascular risk factors are essential for prevention of cardiovascular morbidity in AAV patients.
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In this issue
The Journal of Rheumatology
Vol. 50, Issue 1
1 Jan 2023
Accepted manuscript
Traditional and disease specific risk factors for cardiovascular events in ANCA-associated vasculitis: a multinational retrospective study
Sergey Moiseev, Nikolay Bulanov, Matija Crnogorac, Haner Direskeneli, Kresimir Galesic, Ummugulsum Gazel, Duvuru Geetha, Loic Guillevin, Zdenka Hrušková, Mark A. Little, Liam O'Neill, Egor Makarov, Stephen P. McAdoo, Aladdin J. Mohammad, Sarah Moran, Pavel Novikov, Charles D. Pusey, Chinar Rahmattulla, Veronika Satrapová, Joana Silva, Alexander Suvorov, Vladimír Tesar, Benjamin Terrier, Peter Willeit, Ming-Hui Zhao, Andreas Kronbichler, David R. W. Jayne
The Journal of Rheumatology Jan 2023, jrheum.220851; DOI: 10.3899/jrheum.220851
Accepted manuscript
Traditional and disease specific risk factors for cardiovascular events in ANCA-associated vasculitis: a multinational retrospective study
Sergey Moiseev, Nikolay Bulanov, Matija Crnogorac, Haner Direskeneli, Kresimir Galesic, Ummugulsum Gazel, Duvuru Geetha, Loic Guillevin, Zdenka Hrušková, Mark A. Little, Liam O'Neill, Egor Makarov, Stephen P. McAdoo, Aladdin J. Mohammad, Sarah Moran, Pavel Novikov, Charles D. Pusey, Chinar Rahmattulla, Veronika Satrapová, Joana Silva, Alexander Suvorov, Vladimír Tesar, Benjamin Terrier, Peter Willeit, Ming-Hui Zhao, Andreas Kronbichler, David R. W. Jayne
The Journal of Rheumatology Jan 2023, jrheum.220851; DOI: 10.3899/jrheum.220851
