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Research ArticleAccepted Articles
Open Access

Preferences for COVID-19 vaccination in people with chronic immune-mediated inflammatory diseases

Glen S. Hazlewood, Ines Colmegna, Carol Hitchon, Paul R. Fortin, Sasha Bernatsk, Ann E. Clarke, Dianne Mosher, Todd Wilson, Megan Thomas, Claire Barber, Mark Harrison, Nick Bansback, Laurie Proulx, Dawn P. Richards and Gilaad G. Kaplan
The Journal of Rheumatology January 2023, jrheum.220697; DOI: https://doi.org/10.3899/jrheum.220697
Glen S. Hazlewood
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada. Arthritis Research Canada, Vancouver, British Columbia, Canada. The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Division de Rhumatologie, Département de Médecine, CHU de Québec - Université Laval, Québec City, Québec, Canada. Centre de Recherche ARThrite - Arthrite, Recherche et Traitements, Université Laval, Québec City, Québec, Canada. Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, British Columbia, Canada. Canadian Arthritis Patient Alliance, Ontario, Canada. Sources of support: This work was supported by the Canadian Rheumatology Association; a Canadian Institutes of Health Research Operating Grant: COVID-19 Rapid Research Funding Opportunity [Funding Reference umber VR5-172684]; and the Public Health Agency of Canada through the Vaccine Surveillance Reference Group (VSRG) and the COVID-19 Immunity Task Force (CITY). Dr. Hazlewood is supported by a Canadian Institutes of Health Research New Investigator Award. Dr Fortin holds a tier 1 Canada Research Chair on Systemic Autoimmune Rheumatic Diseases. Dr. Clarke holds The Arthritis Society Chair in Rheumatic Diseases at the University of Calgary. Dr. Harrison received salary support through a 2017 Scholar Award from the Michael Smith Foundation for Health Services Research. Correspondence to: Glen S Hazlewood, Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, T2N 4Z6, Canada. E-mail: gshazlew@ucalgary.ca.
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Ines Colmegna
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada. Arthritis Research Canada, Vancouver, British Columbia, Canada. The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Division de Rhumatologie, Département de Médecine, CHU de Québec - Université Laval, Québec City, Québec, Canada. Centre de Recherche ARThrite - Arthrite, Recherche et Traitements, Université Laval, Québec City, Québec, Canada. Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, British Columbia, Canada. Canadian Arthritis Patient Alliance, Ontario, Canada. Sources of support: This work was supported by the Canadian Rheumatology Association; a Canadian Institutes of Health Research Operating Grant: COVID-19 Rapid Research Funding Opportunity [Funding Reference umber VR5-172684]; and the Public Health Agency of Canada through the Vaccine Surveillance Reference Group (VSRG) and the COVID-19 Immunity Task Force (CITY). Dr. Hazlewood is supported by a Canadian Institutes of Health Research New Investigator Award. Dr Fortin holds a tier 1 Canada Research Chair on Systemic Autoimmune Rheumatic Diseases. Dr. Clarke holds The Arthritis Society Chair in Rheumatic Diseases at the University of Calgary. Dr. Harrison received salary support through a 2017 Scholar Award from the Michael Smith Foundation for Health Services Research. Correspondence to: Glen S Hazlewood, Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, T2N 4Z6, Canada. E-mail: gshazlew@ucalgary.ca.
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Carol Hitchon
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada. Arthritis Research Canada, Vancouver, British Columbia, Canada. The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Division de Rhumatologie, Département de Médecine, CHU de Québec - Université Laval, Québec City, Québec, Canada. Centre de Recherche ARThrite - Arthrite, Recherche et Traitements, Université Laval, Québec City, Québec, Canada. Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, British Columbia, Canada. Canadian Arthritis Patient Alliance, Ontario, Canada. Sources of support: This work was supported by the Canadian Rheumatology Association; a Canadian Institutes of Health Research Operating Grant: COVID-19 Rapid Research Funding Opportunity [Funding Reference umber VR5-172684]; and the Public Health Agency of Canada through the Vaccine Surveillance Reference Group (VSRG) and the COVID-19 Immunity Task Force (CITY). Dr. Hazlewood is supported by a Canadian Institutes of Health Research New Investigator Award. Dr Fortin holds a tier 1 Canada Research Chair on Systemic Autoimmune Rheumatic Diseases. Dr. Clarke holds The Arthritis Society Chair in Rheumatic Diseases at the University of Calgary. Dr. Harrison received salary support through a 2017 Scholar Award from the Michael Smith Foundation for Health Services Research. Correspondence to: Glen S Hazlewood, Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, T2N 4Z6, Canada. E-mail: gshazlew@ucalgary.ca.
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Paul R. Fortin
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada. Arthritis Research Canada, Vancouver, British Columbia, Canada. The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Division de Rhumatologie, Département de Médecine, CHU de Québec - Université Laval, Québec City, Québec, Canada. Centre de Recherche ARThrite - Arthrite, Recherche et Traitements, Université Laval, Québec City, Québec, Canada. Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, British Columbia, Canada. Canadian Arthritis Patient Alliance, Ontario, Canada. Sources of support: This work was supported by the Canadian Rheumatology Association; a Canadian Institutes of Health Research Operating Grant: COVID-19 Rapid Research Funding Opportunity [Funding Reference umber VR5-172684]; and the Public Health Agency of Canada through the Vaccine Surveillance Reference Group (VSRG) and the COVID-19 Immunity Task Force (CITY). Dr. Hazlewood is supported by a Canadian Institutes of Health Research New Investigator Award. Dr Fortin holds a tier 1 Canada Research Chair on Systemic Autoimmune Rheumatic Diseases. Dr. Clarke holds The Arthritis Society Chair in Rheumatic Diseases at the University of Calgary. Dr. Harrison received salary support through a 2017 Scholar Award from the Michael Smith Foundation for Health Services Research. Correspondence to: Glen S Hazlewood, Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, T2N 4Z6, Canada. E-mail: gshazlew@ucalgary.ca.
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Sasha Bernatsk
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada. Arthritis Research Canada, Vancouver, British Columbia, Canada. The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Division de Rhumatologie, Département de Médecine, CHU de Québec - Université Laval, Québec City, Québec, Canada. Centre de Recherche ARThrite - Arthrite, Recherche et Traitements, Université Laval, Québec City, Québec, Canada. Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, British Columbia, Canada. Canadian Arthritis Patient Alliance, Ontario, Canada. Sources of support: This work was supported by the Canadian Rheumatology Association; a Canadian Institutes of Health Research Operating Grant: COVID-19 Rapid Research Funding Opportunity [Funding Reference umber VR5-172684]; and the Public Health Agency of Canada through the Vaccine Surveillance Reference Group (VSRG) and the COVID-19 Immunity Task Force (CITY). Dr. Hazlewood is supported by a Canadian Institutes of Health Research New Investigator Award. Dr Fortin holds a tier 1 Canada Research Chair on Systemic Autoimmune Rheumatic Diseases. Dr. Clarke holds The Arthritis Society Chair in Rheumatic Diseases at the University of Calgary. Dr. Harrison received salary support through a 2017 Scholar Award from the Michael Smith Foundation for Health Services Research. Correspondence to: Glen S Hazlewood, Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, T2N 4Z6, Canada. E-mail: gshazlew@ucalgary.ca.
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Ann E. Clarke
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada. Arthritis Research Canada, Vancouver, British Columbia, Canada. The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Division de Rhumatologie, Département de Médecine, CHU de Québec - Université Laval, Québec City, Québec, Canada. Centre de Recherche ARThrite - Arthrite, Recherche et Traitements, Université Laval, Québec City, Québec, Canada. Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, British Columbia, Canada. Canadian Arthritis Patient Alliance, Ontario, Canada. Sources of support: This work was supported by the Canadian Rheumatology Association; a Canadian Institutes of Health Research Operating Grant: COVID-19 Rapid Research Funding Opportunity [Funding Reference umber VR5-172684]; and the Public Health Agency of Canada through the Vaccine Surveillance Reference Group (VSRG) and the COVID-19 Immunity Task Force (CITY). Dr. Hazlewood is supported by a Canadian Institutes of Health Research New Investigator Award. Dr Fortin holds a tier 1 Canada Research Chair on Systemic Autoimmune Rheumatic Diseases. Dr. Clarke holds The Arthritis Society Chair in Rheumatic Diseases at the University of Calgary. Dr. Harrison received salary support through a 2017 Scholar Award from the Michael Smith Foundation for Health Services Research. Correspondence to: Glen S Hazlewood, Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, T2N 4Z6, Canada. E-mail: gshazlew@ucalgary.ca.
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Dianne Mosher
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada. Arthritis Research Canada, Vancouver, British Columbia, Canada. The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Division de Rhumatologie, Département de Médecine, CHU de Québec - Université Laval, Québec City, Québec, Canada. Centre de Recherche ARThrite - Arthrite, Recherche et Traitements, Université Laval, Québec City, Québec, Canada. Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, British Columbia, Canada. Canadian Arthritis Patient Alliance, Ontario, Canada. Sources of support: This work was supported by the Canadian Rheumatology Association; a Canadian Institutes of Health Research Operating Grant: COVID-19 Rapid Research Funding Opportunity [Funding Reference umber VR5-172684]; and the Public Health Agency of Canada through the Vaccine Surveillance Reference Group (VSRG) and the COVID-19 Immunity Task Force (CITY). Dr. Hazlewood is supported by a Canadian Institutes of Health Research New Investigator Award. Dr Fortin holds a tier 1 Canada Research Chair on Systemic Autoimmune Rheumatic Diseases. Dr. Clarke holds The Arthritis Society Chair in Rheumatic Diseases at the University of Calgary. Dr. Harrison received salary support through a 2017 Scholar Award from the Michael Smith Foundation for Health Services Research. Correspondence to: Glen S Hazlewood, Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, T2N 4Z6, Canada. E-mail: gshazlew@ucalgary.ca.
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Todd Wilson
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada. Arthritis Research Canada, Vancouver, British Columbia, Canada. The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Division de Rhumatologie, Département de Médecine, CHU de Québec - Université Laval, Québec City, Québec, Canada. Centre de Recherche ARThrite - Arthrite, Recherche et Traitements, Université Laval, Québec City, Québec, Canada. Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, British Columbia, Canada. Canadian Arthritis Patient Alliance, Ontario, Canada. Sources of support: This work was supported by the Canadian Rheumatology Association; a Canadian Institutes of Health Research Operating Grant: COVID-19 Rapid Research Funding Opportunity [Funding Reference umber VR5-172684]; and the Public Health Agency of Canada through the Vaccine Surveillance Reference Group (VSRG) and the COVID-19 Immunity Task Force (CITY). Dr. Hazlewood is supported by a Canadian Institutes of Health Research New Investigator Award. Dr Fortin holds a tier 1 Canada Research Chair on Systemic Autoimmune Rheumatic Diseases. Dr. Clarke holds The Arthritis Society Chair in Rheumatic Diseases at the University of Calgary. Dr. Harrison received salary support through a 2017 Scholar Award from the Michael Smith Foundation for Health Services Research. Correspondence to: Glen S Hazlewood, Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, T2N 4Z6, Canada. E-mail: gshazlew@ucalgary.ca.
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Megan Thomas
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada. Arthritis Research Canada, Vancouver, British Columbia, Canada. The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Division de Rhumatologie, Département de Médecine, CHU de Québec - Université Laval, Québec City, Québec, Canada. Centre de Recherche ARThrite - Arthrite, Recherche et Traitements, Université Laval, Québec City, Québec, Canada. Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, British Columbia, Canada. Canadian Arthritis Patient Alliance, Ontario, Canada. Sources of support: This work was supported by the Canadian Rheumatology Association; a Canadian Institutes of Health Research Operating Grant: COVID-19 Rapid Research Funding Opportunity [Funding Reference umber VR5-172684]; and the Public Health Agency of Canada through the Vaccine Surveillance Reference Group (VSRG) and the COVID-19 Immunity Task Force (CITY). Dr. Hazlewood is supported by a Canadian Institutes of Health Research New Investigator Award. Dr Fortin holds a tier 1 Canada Research Chair on Systemic Autoimmune Rheumatic Diseases. Dr. Clarke holds The Arthritis Society Chair in Rheumatic Diseases at the University of Calgary. Dr. Harrison received salary support through a 2017 Scholar Award from the Michael Smith Foundation for Health Services Research. Correspondence to: Glen S Hazlewood, Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, T2N 4Z6, Canada. E-mail: gshazlew@ucalgary.ca.
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Claire Barber
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada. Arthritis Research Canada, Vancouver, British Columbia, Canada. The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Division de Rhumatologie, Département de Médecine, CHU de Québec - Université Laval, Québec City, Québec, Canada. Centre de Recherche ARThrite - Arthrite, Recherche et Traitements, Université Laval, Québec City, Québec, Canada. Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, British Columbia, Canada. Canadian Arthritis Patient Alliance, Ontario, Canada. Sources of support: This work was supported by the Canadian Rheumatology Association; a Canadian Institutes of Health Research Operating Grant: COVID-19 Rapid Research Funding Opportunity [Funding Reference umber VR5-172684]; and the Public Health Agency of Canada through the Vaccine Surveillance Reference Group (VSRG) and the COVID-19 Immunity Task Force (CITY). Dr. Hazlewood is supported by a Canadian Institutes of Health Research New Investigator Award. Dr Fortin holds a tier 1 Canada Research Chair on Systemic Autoimmune Rheumatic Diseases. Dr. Clarke holds The Arthritis Society Chair in Rheumatic Diseases at the University of Calgary. Dr. Harrison received salary support through a 2017 Scholar Award from the Michael Smith Foundation for Health Services Research. Correspondence to: Glen S Hazlewood, Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, T2N 4Z6, Canada. E-mail: gshazlew@ucalgary.ca.
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Mark Harrison
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada. Arthritis Research Canada, Vancouver, British Columbia, Canada. The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Division de Rhumatologie, Département de Médecine, CHU de Québec - Université Laval, Québec City, Québec, Canada. Centre de Recherche ARThrite - Arthrite, Recherche et Traitements, Université Laval, Québec City, Québec, Canada. Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, British Columbia, Canada. Canadian Arthritis Patient Alliance, Ontario, Canada. Sources of support: This work was supported by the Canadian Rheumatology Association; a Canadian Institutes of Health Research Operating Grant: COVID-19 Rapid Research Funding Opportunity [Funding Reference umber VR5-172684]; and the Public Health Agency of Canada through the Vaccine Surveillance Reference Group (VSRG) and the COVID-19 Immunity Task Force (CITY). Dr. Hazlewood is supported by a Canadian Institutes of Health Research New Investigator Award. Dr Fortin holds a tier 1 Canada Research Chair on Systemic Autoimmune Rheumatic Diseases. Dr. Clarke holds The Arthritis Society Chair in Rheumatic Diseases at the University of Calgary. Dr. Harrison received salary support through a 2017 Scholar Award from the Michael Smith Foundation for Health Services Research. Correspondence to: Glen S Hazlewood, Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, T2N 4Z6, Canada. E-mail: gshazlew@ucalgary.ca.
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Nick Bansback
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada. Arthritis Research Canada, Vancouver, British Columbia, Canada. The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Division de Rhumatologie, Département de Médecine, CHU de Québec - Université Laval, Québec City, Québec, Canada. Centre de Recherche ARThrite - Arthrite, Recherche et Traitements, Université Laval, Québec City, Québec, Canada. Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, British Columbia, Canada. Canadian Arthritis Patient Alliance, Ontario, Canada. Sources of support: This work was supported by the Canadian Rheumatology Association; a Canadian Institutes of Health Research Operating Grant: COVID-19 Rapid Research Funding Opportunity [Funding Reference umber VR5-172684]; and the Public Health Agency of Canada through the Vaccine Surveillance Reference Group (VSRG) and the COVID-19 Immunity Task Force (CITY). Dr. Hazlewood is supported by a Canadian Institutes of Health Research New Investigator Award. Dr Fortin holds a tier 1 Canada Research Chair on Systemic Autoimmune Rheumatic Diseases. Dr. Clarke holds The Arthritis Society Chair in Rheumatic Diseases at the University of Calgary. Dr. Harrison received salary support through a 2017 Scholar Award from the Michael Smith Foundation for Health Services Research. Correspondence to: Glen S Hazlewood, Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, T2N 4Z6, Canada. E-mail: gshazlew@ucalgary.ca.
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Laurie Proulx
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada. Arthritis Research Canada, Vancouver, British Columbia, Canada. The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Division de Rhumatologie, Département de Médecine, CHU de Québec - Université Laval, Québec City, Québec, Canada. Centre de Recherche ARThrite - Arthrite, Recherche et Traitements, Université Laval, Québec City, Québec, Canada. Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, British Columbia, Canada. Canadian Arthritis Patient Alliance, Ontario, Canada. Sources of support: This work was supported by the Canadian Rheumatology Association; a Canadian Institutes of Health Research Operating Grant: COVID-19 Rapid Research Funding Opportunity [Funding Reference umber VR5-172684]; and the Public Health Agency of Canada through the Vaccine Surveillance Reference Group (VSRG) and the COVID-19 Immunity Task Force (CITY). Dr. Hazlewood is supported by a Canadian Institutes of Health Research New Investigator Award. Dr Fortin holds a tier 1 Canada Research Chair on Systemic Autoimmune Rheumatic Diseases. Dr. Clarke holds The Arthritis Society Chair in Rheumatic Diseases at the University of Calgary. Dr. Harrison received salary support through a 2017 Scholar Award from the Michael Smith Foundation for Health Services Research. Correspondence to: Glen S Hazlewood, Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, T2N 4Z6, Canada. E-mail: gshazlew@ucalgary.ca.
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Dawn P. Richards
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada. Arthritis Research Canada, Vancouver, British Columbia, Canada. The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Division de Rhumatologie, Département de Médecine, CHU de Québec - Université Laval, Québec City, Québec, Canada. Centre de Recherche ARThrite - Arthrite, Recherche et Traitements, Université Laval, Québec City, Québec, Canada. Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, British Columbia, Canada. Canadian Arthritis Patient Alliance, Ontario, Canada. Sources of support: This work was supported by the Canadian Rheumatology Association; a Canadian Institutes of Health Research Operating Grant: COVID-19 Rapid Research Funding Opportunity [Funding Reference umber VR5-172684]; and the Public Health Agency of Canada through the Vaccine Surveillance Reference Group (VSRG) and the COVID-19 Immunity Task Force (CITY). Dr. Hazlewood is supported by a Canadian Institutes of Health Research New Investigator Award. Dr Fortin holds a tier 1 Canada Research Chair on Systemic Autoimmune Rheumatic Diseases. Dr. Clarke holds The Arthritis Society Chair in Rheumatic Diseases at the University of Calgary. Dr. Harrison received salary support through a 2017 Scholar Award from the Michael Smith Foundation for Health Services Research. Correspondence to: Glen S Hazlewood, Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, T2N 4Z6, Canada. E-mail: gshazlew@ucalgary.ca.
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Gilaad G. Kaplan
Department of Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada. Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada. Arthritis Research Canada, Vancouver, British Columbia, Canada. The Research Institute of the McGill University Health Centre, McGill University, Montreal, Quebec, Canada. Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Division de Rhumatologie, Département de Médecine, CHU de Québec - Université Laval, Québec City, Québec, Canada. Centre de Recherche ARThrite - Arthrite, Recherche et Traitements, Université Laval, Québec City, Québec, Canada. Pharmaceutical Sciences, University of British Columbia, Vancouver, British Columbia, Canada. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada. Centre for Health Evaluation and Outcome Sciences, St. Paul's Hospital, Vancouver, British Columbia, Canada. Canadian Arthritis Patient Alliance, Ontario, Canada. Sources of support: This work was supported by the Canadian Rheumatology Association; a Canadian Institutes of Health Research Operating Grant: COVID-19 Rapid Research Funding Opportunity [Funding Reference umber VR5-172684]; and the Public Health Agency of Canada through the Vaccine Surveillance Reference Group (VSRG) and the COVID-19 Immunity Task Force (CITY). Dr. Hazlewood is supported by a Canadian Institutes of Health Research New Investigator Award. Dr Fortin holds a tier 1 Canada Research Chair on Systemic Autoimmune Rheumatic Diseases. Dr. Clarke holds The Arthritis Society Chair in Rheumatic Diseases at the University of Calgary. Dr. Harrison received salary support through a 2017 Scholar Award from the Michael Smith Foundation for Health Services Research. Correspondence to: Glen S Hazlewood, Departments of Medicine and Community Health Sciences, Cumming School of Medicine, University of Calgary, 3280 Hospital Drive NW, Calgary, T2N 4Z6, Canada. E-mail: gshazlew@ucalgary.ca.
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Abstract

Objective To understand how people with chronic immune-mediated inflammatory diseases (IMIDs) trade-off the benefits and risks of COVID-19 vaccine options.

Methods We conducted an online discrete-choice experiment in people with IMIDs to quantify the relative importance of attributes relevant to COVID-19 vaccination. Participants were recruited between May-Aug 2021 through patient groups and clinics in Canada and completed 10 choices where they selected one of 2 hypothetical vaccine options or no vaccine. The relative importance (RI) of each attribute was estimated and heterogeneity was explored through latent class analysis.

Results The survey was completed by 551 people (89% female, mean age 46 years) with a range of IMIDs (48% IBD, 38% RA, 16% SLE). Most had received one (94%) or two (64%) vaccines. Across the ranges of levels considered, vaccine effectiveness was most important (RI = 66%), followed by disease flare (21%), rare but serious risks (9%) and number/timing of shots (4%). Patients would accept a risk of disease flare requiring a treatment change of 8.8% or less, for a vaccine with a small absolute increase in effectiveness (10%). Of the three latent classes, the group with the greatest aversion to disease flare were more likely to be male and have lower incomes, but this group still valued effectiveness higher than other attributes.

Conclusion Patients perceived the benefits of COVID-19 vaccination to outweigh rare serious risks and disease flare. This supports COVID-19 vaccine strategies that maximize effectiveness, while recognizing the heterogeneity in preferences that exists.

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The Journal of Rheumatology
Vol. 50, Issue 2
1 Feb 2023
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Preferences for COVID-19 vaccination in people with chronic immune-mediated inflammatory diseases
Glen S. Hazlewood, Ines Colmegna, Carol Hitchon, Paul R. Fortin, Sasha Bernatsk, Ann E. Clarke, Dianne Mosher, Todd Wilson, Megan Thomas, Claire Barber, Mark Harrison, Nick Bansback, Laurie Proulx, Dawn P. Richards, Gilaad G. Kaplan
The Journal of Rheumatology Jan 2023, jrheum.220697; DOI: 10.3899/jrheum.220697

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Accepted manuscript
Preferences for COVID-19 vaccination in people with chronic immune-mediated inflammatory diseases
Glen S. Hazlewood, Ines Colmegna, Carol Hitchon, Paul R. Fortin, Sasha Bernatsk, Ann E. Clarke, Dianne Mosher, Todd Wilson, Megan Thomas, Claire Barber, Mark Harrison, Nick Bansback, Laurie Proulx, Dawn P. Richards, Gilaad G. Kaplan
The Journal of Rheumatology Jan 2023, jrheum.220697; DOI: 10.3899/jrheum.220697
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