Research ArticleAccepted Articles
Pain Mechanisms Associated with Disease Activity in Patients with Rheumatoid Arthritis Treated with DMARDs: A Regression Tree Analysis
Alyssa Wohlfahrt, Lut fiyya Muhammad, Jing Song, Dorothy Dunlop, Tuhina Neogi, Clifton O. Bingham III, Marcy B. Bolster, Wendy Marder, Daniel J. Clauw and Yvonne C. Lee
The Journal of Rheumatology January 2023, jrheum.220500; DOI: https://doi.org/10.3899/jrheum.220500
Alyssa Wohlfahrt
Alyssa Wohlfahrt, MS: Tufts University School of Medicine, Boston, Massachusetts. Lutfiyya Muhammad, PhD, MPH: Northwestern University, Chicago, Illinois. Jing Song, MS: Northwestern University, Chicago, Illinois. Dorothy Dunlop, PhD: Northwestern University, Chicago, Illinois. Tuhina Neogi, MD, PhD: Boston University School of Medicine, Boston, Massachusetts. Clifton O. Bingham III, MD: Johns Hopkins University School of Medicine, Baltimore, Maryland. Marcy B. Bolster, MD: Massachusetts General Hospital, Boston, Massachusetts. Wendy Marder, MD, MS: University of Michigan, Ann Arbor, Michigan. Daniel J. Clauw, MD: University of Michigan, Ann Arbor, Michigan. Yvonne C. Lee, MD, MMSc: Northwestern University, Chicago, Illinois. FUNDING: This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health [R01-AR-064850, P30-AR-07257, K24 AR070892 to TN, and P30 AR070254 to CB]. DISCLOSURE STATEMENTS: Yvonne Lee, MD owns stock or stock options in Cigna and has received research support from Pfizer. Marcy B. Bolster, MD has research grants from Corbus, Cumberland, Inc, Genentech, Amgen, AbbVie, Pfizer, and Rheumatology Research Foundation. All other authors declare no conflicts of interest. Correspondence: Yvonne C. Lee, MD, MMSc, Northwestern University Feinberg School of Medicine, Medicine/Rheumatology, 18th Floor, 633 North St. Clair Street, Chicago, IL 60611. Email: Yvonne.lee@northwestern.edu
Lut fiyya Muhammad
Alyssa Wohlfahrt, MS: Tufts University School of Medicine, Boston, Massachusetts. Lutfiyya Muhammad, PhD, MPH: Northwestern University, Chicago, Illinois. Jing Song, MS: Northwestern University, Chicago, Illinois. Dorothy Dunlop, PhD: Northwestern University, Chicago, Illinois. Tuhina Neogi, MD, PhD: Boston University School of Medicine, Boston, Massachusetts. Clifton O. Bingham III, MD: Johns Hopkins University School of Medicine, Baltimore, Maryland. Marcy B. Bolster, MD: Massachusetts General Hospital, Boston, Massachusetts. Wendy Marder, MD, MS: University of Michigan, Ann Arbor, Michigan. Daniel J. Clauw, MD: University of Michigan, Ann Arbor, Michigan. Yvonne C. Lee, MD, MMSc: Northwestern University, Chicago, Illinois. FUNDING: This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health [R01-AR-064850, P30-AR-07257, K24 AR070892 to TN, and P30 AR070254 to CB]. DISCLOSURE STATEMENTS: Yvonne Lee, MD owns stock or stock options in Cigna and has received research support from Pfizer. Marcy B. Bolster, MD has research grants from Corbus, Cumberland, Inc, Genentech, Amgen, AbbVie, Pfizer, and Rheumatology Research Foundation. All other authors declare no conflicts of interest. Correspondence: Yvonne C. Lee, MD, MMSc, Northwestern University Feinberg School of Medicine, Medicine/Rheumatology, 18th Floor, 633 North St. Clair Street, Chicago, IL 60611. Email: Yvonne.lee@northwestern.edu
Jing Song
Alyssa Wohlfahrt, MS: Tufts University School of Medicine, Boston, Massachusetts. Lutfiyya Muhammad, PhD, MPH: Northwestern University, Chicago, Illinois. Jing Song, MS: Northwestern University, Chicago, Illinois. Dorothy Dunlop, PhD: Northwestern University, Chicago, Illinois. Tuhina Neogi, MD, PhD: Boston University School of Medicine, Boston, Massachusetts. Clifton O. Bingham III, MD: Johns Hopkins University School of Medicine, Baltimore, Maryland. Marcy B. Bolster, MD: Massachusetts General Hospital, Boston, Massachusetts. Wendy Marder, MD, MS: University of Michigan, Ann Arbor, Michigan. Daniel J. Clauw, MD: University of Michigan, Ann Arbor, Michigan. Yvonne C. Lee, MD, MMSc: Northwestern University, Chicago, Illinois. FUNDING: This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health [R01-AR-064850, P30-AR-07257, K24 AR070892 to TN, and P30 AR070254 to CB]. DISCLOSURE STATEMENTS: Yvonne Lee, MD owns stock or stock options in Cigna and has received research support from Pfizer. Marcy B. Bolster, MD has research grants from Corbus, Cumberland, Inc, Genentech, Amgen, AbbVie, Pfizer, and Rheumatology Research Foundation. All other authors declare no conflicts of interest. Correspondence: Yvonne C. Lee, MD, MMSc, Northwestern University Feinberg School of Medicine, Medicine/Rheumatology, 18th Floor, 633 North St. Clair Street, Chicago, IL 60611. Email: Yvonne.lee@northwestern.edu
Dorothy Dunlop
Alyssa Wohlfahrt, MS: Tufts University School of Medicine, Boston, Massachusetts. Lutfiyya Muhammad, PhD, MPH: Northwestern University, Chicago, Illinois. Jing Song, MS: Northwestern University, Chicago, Illinois. Dorothy Dunlop, PhD: Northwestern University, Chicago, Illinois. Tuhina Neogi, MD, PhD: Boston University School of Medicine, Boston, Massachusetts. Clifton O. Bingham III, MD: Johns Hopkins University School of Medicine, Baltimore, Maryland. Marcy B. Bolster, MD: Massachusetts General Hospital, Boston, Massachusetts. Wendy Marder, MD, MS: University of Michigan, Ann Arbor, Michigan. Daniel J. Clauw, MD: University of Michigan, Ann Arbor, Michigan. Yvonne C. Lee, MD, MMSc: Northwestern University, Chicago, Illinois. FUNDING: This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health [R01-AR-064850, P30-AR-07257, K24 AR070892 to TN, and P30 AR070254 to CB]. DISCLOSURE STATEMENTS: Yvonne Lee, MD owns stock or stock options in Cigna and has received research support from Pfizer. Marcy B. Bolster, MD has research grants from Corbus, Cumberland, Inc, Genentech, Amgen, AbbVie, Pfizer, and Rheumatology Research Foundation. All other authors declare no conflicts of interest. Correspondence: Yvonne C. Lee, MD, MMSc, Northwestern University Feinberg School of Medicine, Medicine/Rheumatology, 18th Floor, 633 North St. Clair Street, Chicago, IL 60611. Email: Yvonne.lee@northwestern.edu
Tuhina Neogi
Alyssa Wohlfahrt, MS: Tufts University School of Medicine, Boston, Massachusetts. Lutfiyya Muhammad, PhD, MPH: Northwestern University, Chicago, Illinois. Jing Song, MS: Northwestern University, Chicago, Illinois. Dorothy Dunlop, PhD: Northwestern University, Chicago, Illinois. Tuhina Neogi, MD, PhD: Boston University School of Medicine, Boston, Massachusetts. Clifton O. Bingham III, MD: Johns Hopkins University School of Medicine, Baltimore, Maryland. Marcy B. Bolster, MD: Massachusetts General Hospital, Boston, Massachusetts. Wendy Marder, MD, MS: University of Michigan, Ann Arbor, Michigan. Daniel J. Clauw, MD: University of Michigan, Ann Arbor, Michigan. Yvonne C. Lee, MD, MMSc: Northwestern University, Chicago, Illinois. FUNDING: This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health [R01-AR-064850, P30-AR-07257, K24 AR070892 to TN, and P30 AR070254 to CB]. DISCLOSURE STATEMENTS: Yvonne Lee, MD owns stock or stock options in Cigna and has received research support from Pfizer. Marcy B. Bolster, MD has research grants from Corbus, Cumberland, Inc, Genentech, Amgen, AbbVie, Pfizer, and Rheumatology Research Foundation. All other authors declare no conflicts of interest. Correspondence: Yvonne C. Lee, MD, MMSc, Northwestern University Feinberg School of Medicine, Medicine/Rheumatology, 18th Floor, 633 North St. Clair Street, Chicago, IL 60611. Email: Yvonne.lee@northwestern.edu
Clifton O. Bingham III
Alyssa Wohlfahrt, MS: Tufts University School of Medicine, Boston, Massachusetts. Lutfiyya Muhammad, PhD, MPH: Northwestern University, Chicago, Illinois. Jing Song, MS: Northwestern University, Chicago, Illinois. Dorothy Dunlop, PhD: Northwestern University, Chicago, Illinois. Tuhina Neogi, MD, PhD: Boston University School of Medicine, Boston, Massachusetts. Clifton O. Bingham III, MD: Johns Hopkins University School of Medicine, Baltimore, Maryland. Marcy B. Bolster, MD: Massachusetts General Hospital, Boston, Massachusetts. Wendy Marder, MD, MS: University of Michigan, Ann Arbor, Michigan. Daniel J. Clauw, MD: University of Michigan, Ann Arbor, Michigan. Yvonne C. Lee, MD, MMSc: Northwestern University, Chicago, Illinois. FUNDING: This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health [R01-AR-064850, P30-AR-07257, K24 AR070892 to TN, and P30 AR070254 to CB]. DISCLOSURE STATEMENTS: Yvonne Lee, MD owns stock or stock options in Cigna and has received research support from Pfizer. Marcy B. Bolster, MD has research grants from Corbus, Cumberland, Inc, Genentech, Amgen, AbbVie, Pfizer, and Rheumatology Research Foundation. All other authors declare no conflicts of interest. Correspondence: Yvonne C. Lee, MD, MMSc, Northwestern University Feinberg School of Medicine, Medicine/Rheumatology, 18th Floor, 633 North St. Clair Street, Chicago, IL 60611. Email: Yvonne.lee@northwestern.edu
Marcy B. Bolster
Alyssa Wohlfahrt, MS: Tufts University School of Medicine, Boston, Massachusetts. Lutfiyya Muhammad, PhD, MPH: Northwestern University, Chicago, Illinois. Jing Song, MS: Northwestern University, Chicago, Illinois. Dorothy Dunlop, PhD: Northwestern University, Chicago, Illinois. Tuhina Neogi, MD, PhD: Boston University School of Medicine, Boston, Massachusetts. Clifton O. Bingham III, MD: Johns Hopkins University School of Medicine, Baltimore, Maryland. Marcy B. Bolster, MD: Massachusetts General Hospital, Boston, Massachusetts. Wendy Marder, MD, MS: University of Michigan, Ann Arbor, Michigan. Daniel J. Clauw, MD: University of Michigan, Ann Arbor, Michigan. Yvonne C. Lee, MD, MMSc: Northwestern University, Chicago, Illinois. FUNDING: This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health [R01-AR-064850, P30-AR-07257, K24 AR070892 to TN, and P30 AR070254 to CB]. DISCLOSURE STATEMENTS: Yvonne Lee, MD owns stock or stock options in Cigna and has received research support from Pfizer. Marcy B. Bolster, MD has research grants from Corbus, Cumberland, Inc, Genentech, Amgen, AbbVie, Pfizer, and Rheumatology Research Foundation. All other authors declare no conflicts of interest. Correspondence: Yvonne C. Lee, MD, MMSc, Northwestern University Feinberg School of Medicine, Medicine/Rheumatology, 18th Floor, 633 North St. Clair Street, Chicago, IL 60611. Email: Yvonne.lee@northwestern.edu
Wendy Marder
Alyssa Wohlfahrt, MS: Tufts University School of Medicine, Boston, Massachusetts. Lutfiyya Muhammad, PhD, MPH: Northwestern University, Chicago, Illinois. Jing Song, MS: Northwestern University, Chicago, Illinois. Dorothy Dunlop, PhD: Northwestern University, Chicago, Illinois. Tuhina Neogi, MD, PhD: Boston University School of Medicine, Boston, Massachusetts. Clifton O. Bingham III, MD: Johns Hopkins University School of Medicine, Baltimore, Maryland. Marcy B. Bolster, MD: Massachusetts General Hospital, Boston, Massachusetts. Wendy Marder, MD, MS: University of Michigan, Ann Arbor, Michigan. Daniel J. Clauw, MD: University of Michigan, Ann Arbor, Michigan. Yvonne C. Lee, MD, MMSc: Northwestern University, Chicago, Illinois. FUNDING: This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health [R01-AR-064850, P30-AR-07257, K24 AR070892 to TN, and P30 AR070254 to CB]. DISCLOSURE STATEMENTS: Yvonne Lee, MD owns stock or stock options in Cigna and has received research support from Pfizer. Marcy B. Bolster, MD has research grants from Corbus, Cumberland, Inc, Genentech, Amgen, AbbVie, Pfizer, and Rheumatology Research Foundation. All other authors declare no conflicts of interest. Correspondence: Yvonne C. Lee, MD, MMSc, Northwestern University Feinberg School of Medicine, Medicine/Rheumatology, 18th Floor, 633 North St. Clair Street, Chicago, IL 60611. Email: Yvonne.lee@northwestern.edu
Daniel J. Clauw
Alyssa Wohlfahrt, MS: Tufts University School of Medicine, Boston, Massachusetts. Lutfiyya Muhammad, PhD, MPH: Northwestern University, Chicago, Illinois. Jing Song, MS: Northwestern University, Chicago, Illinois. Dorothy Dunlop, PhD: Northwestern University, Chicago, Illinois. Tuhina Neogi, MD, PhD: Boston University School of Medicine, Boston, Massachusetts. Clifton O. Bingham III, MD: Johns Hopkins University School of Medicine, Baltimore, Maryland. Marcy B. Bolster, MD: Massachusetts General Hospital, Boston, Massachusetts. Wendy Marder, MD, MS: University of Michigan, Ann Arbor, Michigan. Daniel J. Clauw, MD: University of Michigan, Ann Arbor, Michigan. Yvonne C. Lee, MD, MMSc: Northwestern University, Chicago, Illinois. FUNDING: This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health [R01-AR-064850, P30-AR-07257, K24 AR070892 to TN, and P30 AR070254 to CB]. DISCLOSURE STATEMENTS: Yvonne Lee, MD owns stock or stock options in Cigna and has received research support from Pfizer. Marcy B. Bolster, MD has research grants from Corbus, Cumberland, Inc, Genentech, Amgen, AbbVie, Pfizer, and Rheumatology Research Foundation. All other authors declare no conflicts of interest. Correspondence: Yvonne C. Lee, MD, MMSc, Northwestern University Feinberg School of Medicine, Medicine/Rheumatology, 18th Floor, 633 North St. Clair Street, Chicago, IL 60611. Email: Yvonne.lee@northwestern.edu
Yvonne C. Lee
Alyssa Wohlfahrt, MS: Tufts University School of Medicine, Boston, Massachusetts. Lutfiyya Muhammad, PhD, MPH: Northwestern University, Chicago, Illinois. Jing Song, MS: Northwestern University, Chicago, Illinois. Dorothy Dunlop, PhD: Northwestern University, Chicago, Illinois. Tuhina Neogi, MD, PhD: Boston University School of Medicine, Boston, Massachusetts. Clifton O. Bingham III, MD: Johns Hopkins University School of Medicine, Baltimore, Maryland. Marcy B. Bolster, MD: Massachusetts General Hospital, Boston, Massachusetts. Wendy Marder, MD, MS: University of Michigan, Ann Arbor, Michigan. Daniel J. Clauw, MD: University of Michigan, Ann Arbor, Michigan. Yvonne C. Lee, MD, MMSc: Northwestern University, Chicago, Illinois. FUNDING: This work was supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases at the National Institutes of Health [R01-AR-064850, P30-AR-07257, K24 AR070892 to TN, and P30 AR070254 to CB]. DISCLOSURE STATEMENTS: Yvonne Lee, MD owns stock or stock options in Cigna and has received research support from Pfizer. Marcy B. Bolster, MD has research grants from Corbus, Cumberland, Inc, Genentech, Amgen, AbbVie, Pfizer, and Rheumatology Research Foundation. All other authors declare no conflicts of interest. Correspondence: Yvonne C. Lee, MD, MMSc, Northwestern University Feinberg School of Medicine, Medicine/Rheumatology, 18th Floor, 633 North St. Clair Street, Chicago, IL 60611. Email: Yvonne.lee@northwestern.edu
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Accepted manuscript
Pain Mechanisms Associated with Disease Activity in Patients with Rheumatoid Arthritis Treated with DMARDs: A Regression Tree Analysis
Alyssa Wohlfahrt, Lut fiyya Muhammad, Jing Song, Dorothy Dunlop, Tuhina Neogi, Clifton O. Bingham, Marcy B. Bolster, Wendy Marder, Daniel J. Clauw, Yvonne C. Lee
The Journal of Rheumatology Jan 2023, jrheum.220500; DOI: 10.3899/jrheum.220500
Accepted manuscript
Pain Mechanisms Associated with Disease Activity in Patients with Rheumatoid Arthritis Treated with DMARDs: A Regression Tree Analysis
Alyssa Wohlfahrt, Lut fiyya Muhammad, Jing Song, Dorothy Dunlop, Tuhina Neogi, Clifton O. Bingham, Marcy B. Bolster, Wendy Marder, Daniel J. Clauw, Yvonne C. Lee
The Journal of Rheumatology Jan 2023, jrheum.220500; DOI: 10.3899/jrheum.220500