Skip to main content

Main menu

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • Privacy/GDPR Policy
    • Accessibility
  • Contact Us
  • JRheum Supplements
  • Services

User menu

  • My Cart
  • Log In

Search

  • Advanced search
The Journal of Rheumatology
  • JRheum Supplements
  • Services
  • My Cart
  • Log In
The Journal of Rheumatology

Advanced Search

  • Home
  • Content
    • First Release
    • Current
    • Archives
    • Collections
    • Audiovisual Rheum
    • COVID-19 and Rheumatology
  • Resources
    • Guide for Authors
    • Submit Manuscript
    • Payment
    • Reviewers
    • Advertisers
    • Classified Ads
    • Reprints and Translations
    • Permissions
    • Meetings
    • FAQ
    • Policies
  • Subscribers
    • Subscription Information
    • Purchase Subscription
    • Your Account
    • Terms and Conditions
  • About Us
    • About Us
    • Editorial Board
    • Letter from the Editor
    • Duncan A. Gordon Award
    • Privacy/GDPR Policy
    • Accessibility
  • Contact Us
  • Follow jrheum on Twitter
  • Visit jrheum on Facebook
  • Follow jrheum on LinkedIn
  • Follow jrheum on YouTube
  • Follow jrheum on Instagram
  • Follow jrheum on RSS
Research ArticleAccepted Article

A systematic review and meta-analysis of predictors of mortality in idiopathic inflammatory myopathy-associated interstitial lung disease

Jennifer Hannah, Huiyi Esther Law, Tanya Gordon, Michael Rooney, April Buazon, Maryam Adas, Deepak Nagra, Christopher Stovin, James Galloway and Patrick Gordon
The Journal of Rheumatology September 2022, jrheum.220383; DOI: https://doi.org/10.3899/jrheum.220383
Jennifer Hannah
Sources of support: JH is supported by a grant from King's College Hospital Charity. They had no role in study design, implementation, analysis or write up of this manuscript. Department of Rheumatology, King's College Hospital NHS Foundation Trust, London, UK. Centre for Rheumatic Disease, School of Immunology & Microbial Sciences, King's College London, London, UK; University of Liverpool School of Medicine, University of Liverpool, London, UK; Guys and St Thomas' NHS Trust, London, UK. Conflict of interest: None declared. Corresponding author: Dr Jennifer Hannah, Department of Academic Rheumatology, Weston Education Centre, King's College London, Denmark Hill, London, SE5 9RS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Huiyi Esther Law
Sources of support: JH is supported by a grant from King's College Hospital Charity. They had no role in study design, implementation, analysis or write up of this manuscript. Department of Rheumatology, King's College Hospital NHS Foundation Trust, London, UK. Centre for Rheumatic Disease, School of Immunology & Microbial Sciences, King's College London, London, UK; University of Liverpool School of Medicine, University of Liverpool, London, UK; Guys and St Thomas' NHS Trust, London, UK. Conflict of interest: None declared. Corresponding author: Dr Jennifer Hannah, Department of Academic Rheumatology, Weston Education Centre, King's College London, Denmark Hill, London, SE5 9RS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tanya Gordon
Sources of support: JH is supported by a grant from King's College Hospital Charity. They had no role in study design, implementation, analysis or write up of this manuscript. Department of Rheumatology, King's College Hospital NHS Foundation Trust, London, UK. Centre for Rheumatic Disease, School of Immunology & Microbial Sciences, King's College London, London, UK; University of Liverpool School of Medicine, University of Liverpool, London, UK; Guys and St Thomas' NHS Trust, London, UK. Conflict of interest: None declared. Corresponding author: Dr Jennifer Hannah, Department of Academic Rheumatology, Weston Education Centre, King's College London, Denmark Hill, London, SE5 9RS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael Rooney
Sources of support: JH is supported by a grant from King's College Hospital Charity. They had no role in study design, implementation, analysis or write up of this manuscript. Department of Rheumatology, King's College Hospital NHS Foundation Trust, London, UK. Centre for Rheumatic Disease, School of Immunology & Microbial Sciences, King's College London, London, UK; University of Liverpool School of Medicine, University of Liverpool, London, UK; Guys and St Thomas' NHS Trust, London, UK. Conflict of interest: None declared. Corresponding author: Dr Jennifer Hannah, Department of Academic Rheumatology, Weston Education Centre, King's College London, Denmark Hill, London, SE5 9RS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
April Buazon
Sources of support: JH is supported by a grant from King's College Hospital Charity. They had no role in study design, implementation, analysis or write up of this manuscript. Department of Rheumatology, King's College Hospital NHS Foundation Trust, London, UK. Centre for Rheumatic Disease, School of Immunology & Microbial Sciences, King's College London, London, UK; University of Liverpool School of Medicine, University of Liverpool, London, UK; Guys and St Thomas' NHS Trust, London, UK. Conflict of interest: None declared. Corresponding author: Dr Jennifer Hannah, Department of Academic Rheumatology, Weston Education Centre, King's College London, Denmark Hill, London, SE5 9RS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maryam Adas
Sources of support: JH is supported by a grant from King's College Hospital Charity. They had no role in study design, implementation, analysis or write up of this manuscript. Department of Rheumatology, King's College Hospital NHS Foundation Trust, London, UK. Centre for Rheumatic Disease, School of Immunology & Microbial Sciences, King's College London, London, UK; University of Liverpool School of Medicine, University of Liverpool, London, UK; Guys and St Thomas' NHS Trust, London, UK. Conflict of interest: None declared. Corresponding author: Dr Jennifer Hannah, Department of Academic Rheumatology, Weston Education Centre, King's College London, Denmark Hill, London, SE5 9RS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Deepak Nagra
Sources of support: JH is supported by a grant from King's College Hospital Charity. They had no role in study design, implementation, analysis or write up of this manuscript. Department of Rheumatology, King's College Hospital NHS Foundation Trust, London, UK. Centre for Rheumatic Disease, School of Immunology & Microbial Sciences, King's College London, London, UK; University of Liverpool School of Medicine, University of Liverpool, London, UK; Guys and St Thomas' NHS Trust, London, UK. Conflict of interest: None declared. Corresponding author: Dr Jennifer Hannah, Department of Academic Rheumatology, Weston Education Centre, King's College London, Denmark Hill, London, SE5 9RS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christopher Stovin
Sources of support: JH is supported by a grant from King's College Hospital Charity. They had no role in study design, implementation, analysis or write up of this manuscript. Department of Rheumatology, King's College Hospital NHS Foundation Trust, London, UK. Centre for Rheumatic Disease, School of Immunology & Microbial Sciences, King's College London, London, UK; University of Liverpool School of Medicine, University of Liverpool, London, UK; Guys and St Thomas' NHS Trust, London, UK. Conflict of interest: None declared. Corresponding author: Dr Jennifer Hannah, Department of Academic Rheumatology, Weston Education Centre, King's College London, Denmark Hill, London, SE5 9RS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James Galloway
Sources of support: JH is supported by a grant from King's College Hospital Charity. They had no role in study design, implementation, analysis or write up of this manuscript. Department of Rheumatology, King's College Hospital NHS Foundation Trust, London, UK. Centre for Rheumatic Disease, School of Immunology & Microbial Sciences, King's College London, London, UK; University of Liverpool School of Medicine, University of Liverpool, London, UK; Guys and St Thomas' NHS Trust, London, UK. Conflict of interest: None declared. Corresponding author: Dr Jennifer Hannah, Department of Academic Rheumatology, Weston Education Centre, King's College London, Denmark Hill, London, SE5 9RS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Patrick Gordon
Sources of support: JH is supported by a grant from King's College Hospital Charity. They had no role in study design, implementation, analysis or write up of this manuscript. Department of Rheumatology, King's College Hospital NHS Foundation Trust, London, UK. Centre for Rheumatic Disease, School of Immunology & Microbial Sciences, King's College London, London, UK; University of Liverpool School of Medicine, University of Liverpool, London, UK; Guys and St Thomas' NHS Trust, London, UK. Conflict of interest: None declared. Corresponding author: Dr Jennifer Hannah, Department of Academic Rheumatology, Weston Education Centre, King's College London, Denmark Hill, London, SE5 9RS
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
  • References
  • PDF
  • eLetters
PreviousNext
Loading

Abstract

Objective Idiopathic inflammatory myopathy-associated interstitial lung disease (IIMILD) can range from rapidly-progressive with high mortality to indolent with minimal morbidity. This systematic review and meta-analysis describes immunological, clinical and radiographical predictors of mortality in IIM-ILD.

Methods MEDLINE and EMBASE database searches were completed on 18/10/21 for articles providing survival data according to baseline characteristics in patients with concurrent IIM and ILD. Prognostic factors common to >5 papers were included in meta-analysis using a random-effects model to report odds ratio for binary variables and hedge's g for continuous variables. Risk of bias was assessed by Newcastle- Ottawa score and Egger's test for publication bias.

Results From 4433 articles, 62 papers were suitable for inclusion, considering 38 different variables. OR for risk of death for anti-MDA-5 was 6.20 (3.58-10.71), and antitRNA- synthetase was protective OR=0.24 (0.14-0.41). ANA, Anti-Ro52 or SS-A did not significantly alter mortality, nor was MDA-5 titre predictive. Age, male gender, acute/sub-acute onset, clinically amyopathic disease, dyspnoea, ulceration, fever, raised CRP, ferritin, LDH, A-aO2 gradient, ground-glass opacities on HRCT and overall HRCT score; and reduced albumin, lymphocytes, PF ratio, %TLCO and %VC are all examples of prognostic factors significantly associated with mortality in this study. Baseline SP-D and KL-6 were not predictors of mortality.

Conclusion Many mortality risk factors were identified, though heterogeneity was high with low quality of evidence and risk of publication bias. Anti-MDA5 disease, and studies from East Asia predominate and may mask risk factors relevant to other IIM subgroups or populations.

Log in using your username and password

Forgot your user name or password?

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top

In this issue

The Journal of Rheumatology
Vol. 50, Issue 1
1 Jan 2023
  • Table of Contents
  • Table of Contents (PDF)
  • Index by Author
  • Editorial Board (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word about The Journal of Rheumatology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
A systematic review and meta-analysis of predictors of mortality in idiopathic inflammatory myopathy-associated interstitial lung disease
(Your Name) has forwarded a page to you from The Journal of Rheumatology
(Your Name) thought you would like to see this page from the The Journal of Rheumatology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Accepted manuscript
A systematic review and meta-analysis of predictors of mortality in idiopathic inflammatory myopathy-associated interstitial lung disease
Jennifer Hannah, Huiyi Esther Law, Tanya Gordon, Michael Rooney, April Buazon, Maryam Adas, Deepak Nagra, Christopher Stovin, James Galloway, Patrick Gordon
The Journal of Rheumatology Sep 2022, jrheum.220383; DOI: 10.3899/jrheum.220383

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

 Request Permissions

Share
Accepted manuscript
A systematic review and meta-analysis of predictors of mortality in idiopathic inflammatory myopathy-associated interstitial lung disease
Jennifer Hannah, Huiyi Esther Law, Tanya Gordon, Michael Rooney, April Buazon, Maryam Adas, Deepak Nagra, Christopher Stovin, James Galloway, Patrick Gordon
The Journal of Rheumatology Sep 2022, jrheum.220383; DOI: 10.3899/jrheum.220383
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
  • Info & Metrics
  • References
  • PDF
  • eLetters

Related Articles

Cited By...

More in this TOC Section

  • Pediatric Sarcoidosis: Retrospective Analysis of Biopsy-proven Patients
Show more Accepted Article

Similar Articles

Content

  • First Release
  • Current
  • Archives
  • Collections
  • Audiovisual Rheum
  • COVID-19 and Rheumatology

Resources

  • Guide for Authors
  • Submit Manuscript
  • Author Payment
  • Reviewers
  • Advertisers
  • Classified Ads
  • Reprints and Translations
  • Permissions
  • Meetings
  • FAQ
  • Policies

Subscribers

  • Subscription Information
  • Purchase Subscription
  • Your Account
  • Terms and Conditions

More

  • About Us
  • Contact Us
  • My Alerts
  • My Folders
  • Privacy/GDPR Policy
  • RSS Feeds
The Journal of Rheumatology
The content of this site is intended for health care professionals.
Copyright © 2022 by The Journal of Rheumatology Publishing Co. Ltd.
Print ISSN: 0315-162X; Online ISSN: 1499-2752
Powered by HighWire