Research ArticleArticle
Hemophagocytic Lymphohistiocytosis Gene Variants in Childhood-Onset Systemic Lupus Erythematosus With Macrophage Activation Syndrome
Piya Lahiry, Sergey Naumenko, Madeline Couse, Fangming Liao, Daniela Dominguez, Andrea Knight, Deborah M. Levy, Melissa Misztal, Lawrence W.K. Ng and Linda T. Hiraki
The Journal of Rheumatology June 2022, jrheum.211200; DOI: https://doi.org/10.3899/jrheum.211200
Piya Lahiry
LTH is supported by The Arthritis Society Stars Career Development Award and is the Canada Research Chair in Genetics of Rare Systemic Inflammatory Diseases. P. Lahiry, MD, PhD, FRCPC, D. Dominguez, MD, MSc, D.M. Levy, MD, MSc, FRCPC, L.W.K. Ng, BSc, Division of Rheumatology, SickKids; S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids; M. Couse, MSc, F. Liao, MSc, M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids; A. Knight, MD, FRCPC, Division of Rheumatology and Research Institute, SickKids; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids, and Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. L.T. Hiraki, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki@sickkids.ca. Accepted for publication May 20, 2022.
Sergey Naumenko
LTH is supported by The Arthritis Society Stars Career Development Award and is the Canada Research Chair in Genetics of Rare Systemic Inflammatory Diseases. P. Lahiry, MD, PhD, FRCPC, D. Dominguez, MD, MSc, D.M. Levy, MD, MSc, FRCPC, L.W.K. Ng, BSc, Division of Rheumatology, SickKids; S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids; M. Couse, MSc, F. Liao, MSc, M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids; A. Knight, MD, FRCPC, Division of Rheumatology and Research Institute, SickKids; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids, and Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. L.T. Hiraki, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki@sickkids.ca. Accepted for publication May 20, 2022.
Madeline Couse
LTH is supported by The Arthritis Society Stars Career Development Award and is the Canada Research Chair in Genetics of Rare Systemic Inflammatory Diseases. P. Lahiry, MD, PhD, FRCPC, D. Dominguez, MD, MSc, D.M. Levy, MD, MSc, FRCPC, L.W.K. Ng, BSc, Division of Rheumatology, SickKids; S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids; M. Couse, MSc, F. Liao, MSc, M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids; A. Knight, MD, FRCPC, Division of Rheumatology and Research Institute, SickKids; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids, and Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. L.T. Hiraki, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki@sickkids.ca. Accepted for publication May 20, 2022.
Fangming Liao
LTH is supported by The Arthritis Society Stars Career Development Award and is the Canada Research Chair in Genetics of Rare Systemic Inflammatory Diseases. P. Lahiry, MD, PhD, FRCPC, D. Dominguez, MD, MSc, D.M. Levy, MD, MSc, FRCPC, L.W.K. Ng, BSc, Division of Rheumatology, SickKids; S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids; M. Couse, MSc, F. Liao, MSc, M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids; A. Knight, MD, FRCPC, Division of Rheumatology and Research Institute, SickKids; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids, and Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. L.T. Hiraki, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki@sickkids.ca. Accepted for publication May 20, 2022.
Daniela Dominguez
LTH is supported by The Arthritis Society Stars Career Development Award and is the Canada Research Chair in Genetics of Rare Systemic Inflammatory Diseases. P. Lahiry, MD, PhD, FRCPC, D. Dominguez, MD, MSc, D.M. Levy, MD, MSc, FRCPC, L.W.K. Ng, BSc, Division of Rheumatology, SickKids; S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids; M. Couse, MSc, F. Liao, MSc, M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids; A. Knight, MD, FRCPC, Division of Rheumatology and Research Institute, SickKids; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids, and Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. L.T. Hiraki, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki@sickkids.ca. Accepted for publication May 20, 2022.
Andrea Knight
LTH is supported by The Arthritis Society Stars Career Development Award and is the Canada Research Chair in Genetics of Rare Systemic Inflammatory Diseases. P. Lahiry, MD, PhD, FRCPC, D. Dominguez, MD, MSc, D.M. Levy, MD, MSc, FRCPC, L.W.K. Ng, BSc, Division of Rheumatology, SickKids; S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids; M. Couse, MSc, F. Liao, MSc, M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids; A. Knight, MD, FRCPC, Division of Rheumatology and Research Institute, SickKids; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids, and Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. L.T. Hiraki, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki@sickkids.ca. Accepted for publication May 20, 2022.
Deborah M. Levy
LTH is supported by The Arthritis Society Stars Career Development Award and is the Canada Research Chair in Genetics of Rare Systemic Inflammatory Diseases. P. Lahiry, MD, PhD, FRCPC, D. Dominguez, MD, MSc, D.M. Levy, MD, MSc, FRCPC, L.W.K. Ng, BSc, Division of Rheumatology, SickKids; S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids; M. Couse, MSc, F. Liao, MSc, M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids; A. Knight, MD, FRCPC, Division of Rheumatology and Research Institute, SickKids; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids, and Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. L.T. Hiraki, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki@sickkids.ca. Accepted for publication May 20, 2022.
Melissa Misztal
LTH is supported by The Arthritis Society Stars Career Development Award and is the Canada Research Chair in Genetics of Rare Systemic Inflammatory Diseases. P. Lahiry, MD, PhD, FRCPC, D. Dominguez, MD, MSc, D.M. Levy, MD, MSc, FRCPC, L.W.K. Ng, BSc, Division of Rheumatology, SickKids; S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids; M. Couse, MSc, F. Liao, MSc, M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids; A. Knight, MD, FRCPC, Division of Rheumatology and Research Institute, SickKids; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids, and Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. L.T. Hiraki, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki@sickkids.ca. Accepted for publication May 20, 2022.
Lawrence W.K. Ng
LTH is supported by The Arthritis Society Stars Career Development Award and is the Canada Research Chair in Genetics of Rare Systemic Inflammatory Diseases. P. Lahiry, MD, PhD, FRCPC, D. Dominguez, MD, MSc, D.M. Levy, MD, MSc, FRCPC, L.W.K. Ng, BSc, Division of Rheumatology, SickKids; S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids; M. Couse, MSc, F. Liao, MSc, M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids; A. Knight, MD, FRCPC, Division of Rheumatology and Research Institute, SickKids; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids, and Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. L.T. Hiraki, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki@sickkids.ca. Accepted for publication May 20, 2022.
Linda T. Hiraki
LTH is supported by The Arthritis Society Stars Career Development Award and is the Canada Research Chair in Genetics of Rare Systemic Inflammatory Diseases. P. Lahiry, MD, PhD, FRCPC, D. Dominguez, MD, MSc, D.M. Levy, MD, MSc, FRCPC, L.W.K. Ng, BSc, Division of Rheumatology, SickKids; S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids; M. Couse, MSc, F. Liao, MSc, M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids; A. Knight, MD, FRCPC, Division of Rheumatology and Research Institute, SickKids; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids, and Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. L.T. Hiraki, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki@sickkids.ca. Accepted for publication May 20, 2022.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Hemophagocytic Lymphohistiocytosis Gene Variants in Childhood-Onset Systemic Lupus Erythematosus With Macrophage Activation Syndrome
Piya Lahiry, Sergey Naumenko, Madeline Couse, Fangming Liao, Daniela Dominguez, Andrea Knight, Deborah M. Levy, Melissa Misztal, Lawrence W.K. Ng, Linda T. Hiraki
The Journal of Rheumatology Jun 2022, jrheum.211200; DOI: 10.3899/jrheum.211200
Hemophagocytic Lymphohistiocytosis Gene Variants in Childhood-Onset Systemic Lupus Erythematosus With Macrophage Activation Syndrome
Piya Lahiry, Sergey Naumenko, Madeline Couse, Fangming Liao, Daniela Dominguez, Andrea Knight, Deborah M. Levy, Melissa Misztal, Lawrence W.K. Ng, Linda T. Hiraki
The Journal of Rheumatology Jun 2022, jrheum.211200; DOI: 10.3899/jrheum.211200