A Novel Antineutrophil Extracellular Trap Antibody Targeting Myosin Light Chain 6 in Microscopic Polyangiitis

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University; Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. This study was supported by grants from the Ministry of Health, Labour and Welfare of Japan for the Japan Research Committee for Intractable Vasculitis ( JPVAS; 20FC1044) and the Japan Agency for Medical Research and Development (ek0109360h0003). The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. A. Ishizu, Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-ku, Sapporo 0600812, Japan. Email: aishizu@med. hokudai.ac.jp.

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University; Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. This study was supported by grants from the Ministry of Health, Labour and Welfare of Japan for the Japan Research Committee for Intractable Vasculitis ( JPVAS; 20FC1044) and the Japan Agency for Medical Research and Development (ek0109360h0003). The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. A. Ishizu, Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-ku, Sapporo 0600812, Japan. Email: aishizu@med. hokudai.ac.jp.

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University; Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. This study was supported by grants from the Ministry of Health, Labour and Welfare of Japan for the Japan Research Committee for Intractable Vasculitis ( JPVAS; 20FC1044) and the Japan Agency for Medical Research and Development (ek0109360h0003). The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. A. Ishizu, Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-ku, Sapporo 0600812, Japan. Email: aishizu@med. hokudai.ac.jp.

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University; Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. This study was supported by grants from the Ministry of Health, Labour and Welfare of Japan for the Japan Research Committee for Intractable Vasculitis ( JPVAS; 20FC1044) and the Japan Agency for Medical Research and Development (ek0109360h0003). The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. A. Ishizu, Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-ku, Sapporo 0600812, Japan. Email: aishizu@med. hokudai.ac.jp.

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University; Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. This study was supported by grants from the Ministry of Health, Labour and Welfare of Japan for the Japan Research Committee for Intractable Vasculitis ( JPVAS; 20FC1044) and the Japan Agency for Medical Research and Development (ek0109360h0003). The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. A. Ishizu, Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-ku, Sapporo 0600812, Japan. Email: aishizu@med. hokudai.ac.jp.

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University; Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. This study was supported by grants from the Ministry of Health, Labour and Welfare of Japan for the Japan Research Committee for Intractable Vasculitis ( JPVAS; 20FC1044) and the Japan Agency for Medical Research and Development (ek0109360h0003). The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. A. Ishizu, Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-ku, Sapporo 0600812, Japan. Email: aishizu@med. hokudai.ac.jp.

Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University; Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University; Department of Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan. This study was supported by grants from the Ministry of Health, Labour and Welfare of Japan for the Japan Research Committee for Intractable Vasculitis ( JPVAS; 20FC1044) and the Japan Agency for Medical Research and Development (ek0109360h0003). The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. A. Ishizu, Department of Medical Laboratory Science, Faculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-ku, Sapporo 0600812, Japan. Email: aishizu@med. hokudai.ac.jp.