Research ArticleAccepted Article
Hemophagocytic Lymphohistiocytosis Gene Variants in Childhood-Onset SLE with Macrophage Activation Syndrome
Piya Lahiry, Sergey Naumenko, Madeline Couse, Fangming Liao, Daniela Dominguez, Andrea Knight, Deborah M. Levy, Melissa Misztal, Lawrence W.K. Ng and Linda T. Hiraki
The Journal of Rheumatology June 2022, jrheum.211200; DOI: https://doi.org/10.3899/jrheum.211200
Piya Lahiry
P. Lahiry, MD PhD FRCPC, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids, Toronto, Ontario, Canada; M. Couse, MSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; F. Liao, MSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; D. Dominguez, MD, MSc, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; A. Knight, MD FRCPC, Division of Rheumatology and Research Institute, SickKids, Toronto, Ontario, Canada; D.M. Levy, MD MSc FRCPC, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; L.W.K. Ng, BSc, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids; Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada. Financial Support: Dr. Hiraki - The Arthritis Society, Stars Career Development Award; Canada Research Chair in Genetics of Rare Systemic Inflammatory Diseases. Corresponding Author: Linda T. Hiraki, MD, FRCPC, ScD, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, Ontario, Canada, M5G 0A4, Email: linda.hiraki@sickkids.ca
Sergey Naumenko
P. Lahiry, MD PhD FRCPC, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids, Toronto, Ontario, Canada; M. Couse, MSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; F. Liao, MSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; D. Dominguez, MD, MSc, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; A. Knight, MD FRCPC, Division of Rheumatology and Research Institute, SickKids, Toronto, Ontario, Canada; D.M. Levy, MD MSc FRCPC, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; L.W.K. Ng, BSc, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids; Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada. Financial Support: Dr. Hiraki - The Arthritis Society, Stars Career Development Award; Canada Research Chair in Genetics of Rare Systemic Inflammatory Diseases. Corresponding Author: Linda T. Hiraki, MD, FRCPC, ScD, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, Ontario, Canada, M5G 0A4, Email: linda.hiraki@sickkids.ca
Madeline Couse
P. Lahiry, MD PhD FRCPC, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids, Toronto, Ontario, Canada; M. Couse, MSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; F. Liao, MSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; D. Dominguez, MD, MSc, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; A. Knight, MD FRCPC, Division of Rheumatology and Research Institute, SickKids, Toronto, Ontario, Canada; D.M. Levy, MD MSc FRCPC, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; L.W.K. Ng, BSc, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids; Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada. Financial Support: Dr. Hiraki - The Arthritis Society, Stars Career Development Award; Canada Research Chair in Genetics of Rare Systemic Inflammatory Diseases. Corresponding Author: Linda T. Hiraki, MD, FRCPC, ScD, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, Ontario, Canada, M5G 0A4, Email: linda.hiraki@sickkids.ca
Fangming Liao
P. Lahiry, MD PhD FRCPC, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids, Toronto, Ontario, Canada; M. Couse, MSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; F. Liao, MSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; D. Dominguez, MD, MSc, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; A. Knight, MD FRCPC, Division of Rheumatology and Research Institute, SickKids, Toronto, Ontario, Canada; D.M. Levy, MD MSc FRCPC, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; L.W.K. Ng, BSc, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids; Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada. Financial Support: Dr. Hiraki - The Arthritis Society, Stars Career Development Award; Canada Research Chair in Genetics of Rare Systemic Inflammatory Diseases. Corresponding Author: Linda T. Hiraki, MD, FRCPC, ScD, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, Ontario, Canada, M5G 0A4, Email: linda.hiraki@sickkids.ca
Daniela Dominguez
P. Lahiry, MD PhD FRCPC, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids, Toronto, Ontario, Canada; M. Couse, MSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; F. Liao, MSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; D. Dominguez, MD, MSc, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; A. Knight, MD FRCPC, Division of Rheumatology and Research Institute, SickKids, Toronto, Ontario, Canada; D.M. Levy, MD MSc FRCPC, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; L.W.K. Ng, BSc, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids; Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada. Financial Support: Dr. Hiraki - The Arthritis Society, Stars Career Development Award; Canada Research Chair in Genetics of Rare Systemic Inflammatory Diseases. Corresponding Author: Linda T. Hiraki, MD, FRCPC, ScD, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, Ontario, Canada, M5G 0A4, Email: linda.hiraki@sickkids.ca
Andrea Knight
P. Lahiry, MD PhD FRCPC, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids, Toronto, Ontario, Canada; M. Couse, MSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; F. Liao, MSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; D. Dominguez, MD, MSc, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; A. Knight, MD FRCPC, Division of Rheumatology and Research Institute, SickKids, Toronto, Ontario, Canada; D.M. Levy, MD MSc FRCPC, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; L.W.K. Ng, BSc, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids; Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada. Financial Support: Dr. Hiraki - The Arthritis Society, Stars Career Development Award; Canada Research Chair in Genetics of Rare Systemic Inflammatory Diseases. Corresponding Author: Linda T. Hiraki, MD, FRCPC, ScD, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, Ontario, Canada, M5G 0A4, Email: linda.hiraki@sickkids.ca
Deborah M. Levy
P. Lahiry, MD PhD FRCPC, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids, Toronto, Ontario, Canada; M. Couse, MSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; F. Liao, MSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; D. Dominguez, MD, MSc, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; A. Knight, MD FRCPC, Division of Rheumatology and Research Institute, SickKids, Toronto, Ontario, Canada; D.M. Levy, MD MSc FRCPC, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; L.W.K. Ng, BSc, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids; Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada. Financial Support: Dr. Hiraki - The Arthritis Society, Stars Career Development Award; Canada Research Chair in Genetics of Rare Systemic Inflammatory Diseases. Corresponding Author: Linda T. Hiraki, MD, FRCPC, ScD, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, Ontario, Canada, M5G 0A4, Email: linda.hiraki@sickkids.ca
Melissa Misztal
P. Lahiry, MD PhD FRCPC, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids, Toronto, Ontario, Canada; M. Couse, MSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; F. Liao, MSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; D. Dominguez, MD, MSc, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; A. Knight, MD FRCPC, Division of Rheumatology and Research Institute, SickKids, Toronto, Ontario, Canada; D.M. Levy, MD MSc FRCPC, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; L.W.K. Ng, BSc, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids; Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada. Financial Support: Dr. Hiraki - The Arthritis Society, Stars Career Development Award; Canada Research Chair in Genetics of Rare Systemic Inflammatory Diseases. Corresponding Author: Linda T. Hiraki, MD, FRCPC, ScD, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, Ontario, Canada, M5G 0A4, Email: linda.hiraki@sickkids.ca
Lawrence W.K. Ng
P. Lahiry, MD PhD FRCPC, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids, Toronto, Ontario, Canada; M. Couse, MSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; F. Liao, MSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; D. Dominguez, MD, MSc, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; A. Knight, MD FRCPC, Division of Rheumatology and Research Institute, SickKids, Toronto, Ontario, Canada; D.M. Levy, MD MSc FRCPC, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; L.W.K. Ng, BSc, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids; Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada. Financial Support: Dr. Hiraki - The Arthritis Society, Stars Career Development Award; Canada Research Chair in Genetics of Rare Systemic Inflammatory Diseases. Corresponding Author: Linda T. Hiraki, MD, FRCPC, ScD, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, Ontario, Canada, M5G 0A4, Email: linda.hiraki@sickkids.ca
Linda T. Hiraki
P. Lahiry, MD PhD FRCPC, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; S. Naumenko, PhD, The Centre for Computational Medicine, Research Institute, SickKids, Toronto, Ontario, Canada; M. Couse, MSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; F. Liao, MSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; D. Dominguez, MD, MSc, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; A. Knight, MD FRCPC, Division of Rheumatology and Research Institute, SickKids, Toronto, Ontario, Canada; D.M. Levy, MD MSc FRCPC, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; M. Misztal, BSc, Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada; L.W.K. Ng, BSc, Division of Rheumatology, SickKids, Toronto, Ontario, Canada; L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, SickKids; Genetics & Genome Biology, Research Institute, SickKids, Toronto, Ontario, Canada. Financial Support: Dr. Hiraki - The Arthritis Society, Stars Career Development Award; Canada Research Chair in Genetics of Rare Systemic Inflammatory Diseases. Corresponding Author: Linda T. Hiraki, MD, FRCPC, ScD, Clinical Scientist, Division of Rheumatology, Genetics & Genome Biology, The Peter Gilgan Centre for Research and Learning (PGCRL), SickKids, 686 Bay Street, Toronto, Ontario, Canada, M5G 0A4, Email: linda.hiraki@sickkids.ca
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Accepted manuscript
Hemophagocytic Lymphohistiocytosis Gene Variants in Childhood-Onset SLE with Macrophage Activation Syndrome
Piya Lahiry, Sergey Naumenko, Madeline Couse, Fangming Liao, Daniela Dominguez, Andrea Knight, Deborah M. Levy, Melissa Misztal, Lawrence W.K. Ng, Linda T. Hiraki
The Journal of Rheumatology Jun 2022, jrheum.211200; DOI: 10.3899/jrheum.211200
Accepted manuscript
Hemophagocytic Lymphohistiocytosis Gene Variants in Childhood-Onset SLE with Macrophage Activation Syndrome
Piya Lahiry, Sergey Naumenko, Madeline Couse, Fangming Liao, Daniela Dominguez, Andrea Knight, Deborah M. Levy, Melissa Misztal, Lawrence W.K. Ng, Linda T. Hiraki
The Journal of Rheumatology Jun 2022, jrheum.211200; DOI: 10.3899/jrheum.211200