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Research ArticleArticle

GRAPPA Treatment Recommendations: 2021 Update

Laura C. Coates, Nadia Corp, Danielle A. van der Windt, Denis O'Sullivan, Enrique R. Soriano and Arthur Kavanaugh
The Journal of Rheumatology March 2022, jrheum.211331; DOI: https://doi.org/10.3899/jrheum.211331
Laura C. Coates
As part of the supplement series GRAPPA 2021, this report was reviewed internally and approved by the Guest Editors for integrity, accuracy, and consistency with scientific and ethical standards. L.C. Coates, MB ChB, PhD, Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK; N. Corp, PhD, D.A. van der Windt, PhD, Primary Care Centre Versus Arthritis, School of Medicine, Keele University, Staffordshire, UK; D. O'Sullivan, Our Lady's Hospice & Care Services, Rheumatic and Musculoskeletal Disease Unit, Dublin, Ireland; E.R. Soriano, MD, MSc, Rheumatology Unit, Internal Medicine Services and University Institute, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; A. Kavanaugh, MD, Division of Rheumatology Allergy and Immunology, University of California San Diego, La Jolla, California, USA. The authors declare no conflicts of interest relevant to this article. This paper does not require institutional review board approval. Address correspondence to Dr. A. Kavanaugh, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037-0943, USA. Email: akavanaugh@health.ucsd.edu. Accepted for publication December 8, 2021.
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Nadia Corp
As part of the supplement series GRAPPA 2021, this report was reviewed internally and approved by the Guest Editors for integrity, accuracy, and consistency with scientific and ethical standards. L.C. Coates, MB ChB, PhD, Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK; N. Corp, PhD, D.A. van der Windt, PhD, Primary Care Centre Versus Arthritis, School of Medicine, Keele University, Staffordshire, UK; D. O'Sullivan, Our Lady's Hospice & Care Services, Rheumatic and Musculoskeletal Disease Unit, Dublin, Ireland; E.R. Soriano, MD, MSc, Rheumatology Unit, Internal Medicine Services and University Institute, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; A. Kavanaugh, MD, Division of Rheumatology Allergy and Immunology, University of California San Diego, La Jolla, California, USA. The authors declare no conflicts of interest relevant to this article. This paper does not require institutional review board approval. Address correspondence to Dr. A. Kavanaugh, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037-0943, USA. Email: akavanaugh@health.ucsd.edu. Accepted for publication December 8, 2021.
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Danielle A. van der Windt
As part of the supplement series GRAPPA 2021, this report was reviewed internally and approved by the Guest Editors for integrity, accuracy, and consistency with scientific and ethical standards. L.C. Coates, MB ChB, PhD, Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK; N. Corp, PhD, D.A. van der Windt, PhD, Primary Care Centre Versus Arthritis, School of Medicine, Keele University, Staffordshire, UK; D. O'Sullivan, Our Lady's Hospice & Care Services, Rheumatic and Musculoskeletal Disease Unit, Dublin, Ireland; E.R. Soriano, MD, MSc, Rheumatology Unit, Internal Medicine Services and University Institute, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; A. Kavanaugh, MD, Division of Rheumatology Allergy and Immunology, University of California San Diego, La Jolla, California, USA. The authors declare no conflicts of interest relevant to this article. This paper does not require institutional review board approval. Address correspondence to Dr. A. Kavanaugh, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037-0943, USA. Email: akavanaugh@health.ucsd.edu. Accepted for publication December 8, 2021.
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Denis O'Sullivan
As part of the supplement series GRAPPA 2021, this report was reviewed internally and approved by the Guest Editors for integrity, accuracy, and consistency with scientific and ethical standards. L.C. Coates, MB ChB, PhD, Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK; N. Corp, PhD, D.A. van der Windt, PhD, Primary Care Centre Versus Arthritis, School of Medicine, Keele University, Staffordshire, UK; D. O'Sullivan, Our Lady's Hospice & Care Services, Rheumatic and Musculoskeletal Disease Unit, Dublin, Ireland; E.R. Soriano, MD, MSc, Rheumatology Unit, Internal Medicine Services and University Institute, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; A. Kavanaugh, MD, Division of Rheumatology Allergy and Immunology, University of California San Diego, La Jolla, California, USA. The authors declare no conflicts of interest relevant to this article. This paper does not require institutional review board approval. Address correspondence to Dr. A. Kavanaugh, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037-0943, USA. Email: akavanaugh@health.ucsd.edu. Accepted for publication December 8, 2021.
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Enrique R. Soriano
As part of the supplement series GRAPPA 2021, this report was reviewed internally and approved by the Guest Editors for integrity, accuracy, and consistency with scientific and ethical standards. L.C. Coates, MB ChB, PhD, Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK; N. Corp, PhD, D.A. van der Windt, PhD, Primary Care Centre Versus Arthritis, School of Medicine, Keele University, Staffordshire, UK; D. O'Sullivan, Our Lady's Hospice & Care Services, Rheumatic and Musculoskeletal Disease Unit, Dublin, Ireland; E.R. Soriano, MD, MSc, Rheumatology Unit, Internal Medicine Services and University Institute, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; A. Kavanaugh, MD, Division of Rheumatology Allergy and Immunology, University of California San Diego, La Jolla, California, USA. The authors declare no conflicts of interest relevant to this article. This paper does not require institutional review board approval. Address correspondence to Dr. A. Kavanaugh, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037-0943, USA. Email: akavanaugh@health.ucsd.edu. Accepted for publication December 8, 2021.
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Arthur Kavanaugh
As part of the supplement series GRAPPA 2021, this report was reviewed internally and approved by the Guest Editors for integrity, accuracy, and consistency with scientific and ethical standards. L.C. Coates, MB ChB, PhD, Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK; N. Corp, PhD, D.A. van der Windt, PhD, Primary Care Centre Versus Arthritis, School of Medicine, Keele University, Staffordshire, UK; D. O'Sullivan, Our Lady's Hospice & Care Services, Rheumatic and Musculoskeletal Disease Unit, Dublin, Ireland; E.R. Soriano, MD, MSc, Rheumatology Unit, Internal Medicine Services and University Institute, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina; A. Kavanaugh, MD, Division of Rheumatology Allergy and Immunology, University of California San Diego, La Jolla, California, USA. The authors declare no conflicts of interest relevant to this article. This paper does not require institutional review board approval. Address correspondence to Dr. A. Kavanaugh, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92037-0943, USA. Email: akavanaugh@health.ucsd.edu. Accepted for publication December 8, 2021.
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Abstract

Since its inception, one of the central missions of the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA) has been the development of treatment recommendations for patients with psoriatic arthritis (PsA). The initial guidelines, developed in 2009, were updated in 2015. Because of the abundance of new data concerning the therapeutic approach to PsA, GRAPPA members have been working throughout 2020–2021 to once again update the recommendations. At the GRAPPA 2021 annual meeting, the full committee presented proposals from each of the treatment domain groups, including the comorbidities and related conditions groups, based on previous systematic literature reviews. Overarching principles and summary evidence tables were presented, including results from a GRAPPA membership survey of patients and clinicians to assess levels of agreement. A draft of the figure for the treatment recommendations was presented and discussed with the wider membership.

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The Journal of Rheumatology: 52 (7)
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1 Jul 2025
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GRAPPA Treatment Recommendations: 2021 Update
Laura C. Coates, Nadia Corp, Danielle A. van der Windt, Denis O'Sullivan, Enrique R. Soriano, Arthur Kavanaugh
The Journal of Rheumatology Mar 2022, jrheum.211331; DOI: 10.3899/jrheum.211331

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GRAPPA Treatment Recommendations: 2021 Update
Laura C. Coates, Nadia Corp, Danielle A. van der Windt, Denis O'Sullivan, Enrique R. Soriano, Arthur Kavanaugh
The Journal of Rheumatology Mar 2022, jrheum.211331; DOI: 10.3899/jrheum.211331
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