Research ArticleArticle
Synovitis Is Associated With Constant Pain in Knee Osteoarthritis: A Cross-sectional Study of OMERACT Knee Ultrasound Scores
Holly T. Philpott, Trevor B. Birmingham, Ryan Pinto, Codie A. Primeau, Dominique Arsenault, Brent A. Lanting, Yayuan Zhu and C. Thomas Appleton on behalf of the WOREO Knee Study Group
The Journal of Rheumatology August 2021, jrheum.210285; DOI: https://doi.org/10.3899/jrheum.210285
Holly T. Philpott
This work was financially supported by the Academic Medical Organization of Southwestern Ontario and Western University's Bone and Joint Institute. HTP is supported by a Frederick Banting and Charles Best Doctoral Award from the Canadian Institutes of Health Research. H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, Faculty of Health Sciences, and Bone and Joint Institute, Western University; D. Arsenault, MSc, London Health Sciences Centre, University Hospital; B.A. Lanting, MD, Bone and Joint Institute, and Department of Surgery, Schulich School of Medicine and Dentistry, Western University, and London Health Sciences Centre, University Hospital; Y. Zhu, PhD, Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University; C.T. Appleton, MD, PhD, Bone and Joint Institute, and Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. CTA is a consultant for AbbVie, Amgen, BMS, Celgene, Fresenius Kabi, Gilead, Janssen, Merck, Novartis, Pfizer, Hoffmann-La Roche, Sandoz, Sanofi Genzyme, and UCB. BAL is a consultant and receives institutional support from Stryker, DePuy, Smith & Nephew, and Zimmer; and is a principal investigator with research grants from Stryker, DePuy, and Smith & Nephew. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. C.T. Appleton, St. Joseph's Health Care Rheumatology Centre, 268 Grosvenor St., London, ON N6A 4V2, Canada. Email: tom.appleton@sjhc.london.on.ca. Accepted for publication August 3, 2021.
Trevor B. Birmingham
This work was financially supported by the Academic Medical Organization of Southwestern Ontario and Western University's Bone and Joint Institute. HTP is supported by a Frederick Banting and Charles Best Doctoral Award from the Canadian Institutes of Health Research. H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, Faculty of Health Sciences, and Bone and Joint Institute, Western University; D. Arsenault, MSc, London Health Sciences Centre, University Hospital; B.A. Lanting, MD, Bone and Joint Institute, and Department of Surgery, Schulich School of Medicine and Dentistry, Western University, and London Health Sciences Centre, University Hospital; Y. Zhu, PhD, Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University; C.T. Appleton, MD, PhD, Bone and Joint Institute, and Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. CTA is a consultant for AbbVie, Amgen, BMS, Celgene, Fresenius Kabi, Gilead, Janssen, Merck, Novartis, Pfizer, Hoffmann-La Roche, Sandoz, Sanofi Genzyme, and UCB. BAL is a consultant and receives institutional support from Stryker, DePuy, Smith & Nephew, and Zimmer; and is a principal investigator with research grants from Stryker, DePuy, and Smith & Nephew. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. C.T. Appleton, St. Joseph's Health Care Rheumatology Centre, 268 Grosvenor St., London, ON N6A 4V2, Canada. Email: tom.appleton@sjhc.london.on.ca. Accepted for publication August 3, 2021.
Ryan Pinto
This work was financially supported by the Academic Medical Organization of Southwestern Ontario and Western University's Bone and Joint Institute. HTP is supported by a Frederick Banting and Charles Best Doctoral Award from the Canadian Institutes of Health Research. H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, Faculty of Health Sciences, and Bone and Joint Institute, Western University; D. Arsenault, MSc, London Health Sciences Centre, University Hospital; B.A. Lanting, MD, Bone and Joint Institute, and Department of Surgery, Schulich School of Medicine and Dentistry, Western University, and London Health Sciences Centre, University Hospital; Y. Zhu, PhD, Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University; C.T. Appleton, MD, PhD, Bone and Joint Institute, and Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. CTA is a consultant for AbbVie, Amgen, BMS, Celgene, Fresenius Kabi, Gilead, Janssen, Merck, Novartis, Pfizer, Hoffmann-La Roche, Sandoz, Sanofi Genzyme, and UCB. BAL is a consultant and receives institutional support from Stryker, DePuy, Smith & Nephew, and Zimmer; and is a principal investigator with research grants from Stryker, DePuy, and Smith & Nephew. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. C.T. Appleton, St. Joseph's Health Care Rheumatology Centre, 268 Grosvenor St., London, ON N6A 4V2, Canada. Email: tom.appleton@sjhc.london.on.ca. Accepted for publication August 3, 2021.
Codie A. Primeau
This work was financially supported by the Academic Medical Organization of Southwestern Ontario and Western University's Bone and Joint Institute. HTP is supported by a Frederick Banting and Charles Best Doctoral Award from the Canadian Institutes of Health Research. H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, Faculty of Health Sciences, and Bone and Joint Institute, Western University; D. Arsenault, MSc, London Health Sciences Centre, University Hospital; B.A. Lanting, MD, Bone and Joint Institute, and Department of Surgery, Schulich School of Medicine and Dentistry, Western University, and London Health Sciences Centre, University Hospital; Y. Zhu, PhD, Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University; C.T. Appleton, MD, PhD, Bone and Joint Institute, and Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. CTA is a consultant for AbbVie, Amgen, BMS, Celgene, Fresenius Kabi, Gilead, Janssen, Merck, Novartis, Pfizer, Hoffmann-La Roche, Sandoz, Sanofi Genzyme, and UCB. BAL is a consultant and receives institutional support from Stryker, DePuy, Smith & Nephew, and Zimmer; and is a principal investigator with research grants from Stryker, DePuy, and Smith & Nephew. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. C.T. Appleton, St. Joseph's Health Care Rheumatology Centre, 268 Grosvenor St., London, ON N6A 4V2, Canada. Email: tom.appleton@sjhc.london.on.ca. Accepted for publication August 3, 2021.
Dominique Arsenault
This work was financially supported by the Academic Medical Organization of Southwestern Ontario and Western University's Bone and Joint Institute. HTP is supported by a Frederick Banting and Charles Best Doctoral Award from the Canadian Institutes of Health Research. H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, Faculty of Health Sciences, and Bone and Joint Institute, Western University; D. Arsenault, MSc, London Health Sciences Centre, University Hospital; B.A. Lanting, MD, Bone and Joint Institute, and Department of Surgery, Schulich School of Medicine and Dentistry, Western University, and London Health Sciences Centre, University Hospital; Y. Zhu, PhD, Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University; C.T. Appleton, MD, PhD, Bone and Joint Institute, and Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. CTA is a consultant for AbbVie, Amgen, BMS, Celgene, Fresenius Kabi, Gilead, Janssen, Merck, Novartis, Pfizer, Hoffmann-La Roche, Sandoz, Sanofi Genzyme, and UCB. BAL is a consultant and receives institutional support from Stryker, DePuy, Smith & Nephew, and Zimmer; and is a principal investigator with research grants from Stryker, DePuy, and Smith & Nephew. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. C.T. Appleton, St. Joseph's Health Care Rheumatology Centre, 268 Grosvenor St., London, ON N6A 4V2, Canada. Email: tom.appleton@sjhc.london.on.ca. Accepted for publication August 3, 2021.
Brent A. Lanting
This work was financially supported by the Academic Medical Organization of Southwestern Ontario and Western University's Bone and Joint Institute. HTP is supported by a Frederick Banting and Charles Best Doctoral Award from the Canadian Institutes of Health Research. H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, Faculty of Health Sciences, and Bone and Joint Institute, Western University; D. Arsenault, MSc, London Health Sciences Centre, University Hospital; B.A. Lanting, MD, Bone and Joint Institute, and Department of Surgery, Schulich School of Medicine and Dentistry, Western University, and London Health Sciences Centre, University Hospital; Y. Zhu, PhD, Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University; C.T. Appleton, MD, PhD, Bone and Joint Institute, and Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. CTA is a consultant for AbbVie, Amgen, BMS, Celgene, Fresenius Kabi, Gilead, Janssen, Merck, Novartis, Pfizer, Hoffmann-La Roche, Sandoz, Sanofi Genzyme, and UCB. BAL is a consultant and receives institutional support from Stryker, DePuy, Smith & Nephew, and Zimmer; and is a principal investigator with research grants from Stryker, DePuy, and Smith & Nephew. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. C.T. Appleton, St. Joseph's Health Care Rheumatology Centre, 268 Grosvenor St., London, ON N6A 4V2, Canada. Email: tom.appleton@sjhc.london.on.ca. Accepted for publication August 3, 2021.
Yayuan Zhu
This work was financially supported by the Academic Medical Organization of Southwestern Ontario and Western University's Bone and Joint Institute. HTP is supported by a Frederick Banting and Charles Best Doctoral Award from the Canadian Institutes of Health Research. H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, Faculty of Health Sciences, and Bone and Joint Institute, Western University; D. Arsenault, MSc, London Health Sciences Centre, University Hospital; B.A. Lanting, MD, Bone and Joint Institute, and Department of Surgery, Schulich School of Medicine and Dentistry, Western University, and London Health Sciences Centre, University Hospital; Y. Zhu, PhD, Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University; C.T. Appleton, MD, PhD, Bone and Joint Institute, and Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. CTA is a consultant for AbbVie, Amgen, BMS, Celgene, Fresenius Kabi, Gilead, Janssen, Merck, Novartis, Pfizer, Hoffmann-La Roche, Sandoz, Sanofi Genzyme, and UCB. BAL is a consultant and receives institutional support from Stryker, DePuy, Smith & Nephew, and Zimmer; and is a principal investigator with research grants from Stryker, DePuy, and Smith & Nephew. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. C.T. Appleton, St. Joseph's Health Care Rheumatology Centre, 268 Grosvenor St., London, ON N6A 4V2, Canada. Email: tom.appleton@sjhc.london.on.ca. Accepted for publication August 3, 2021.
C. Thomas Appleton
This work was financially supported by the Academic Medical Organization of Southwestern Ontario and Western University's Bone and Joint Institute. HTP is supported by a Frederick Banting and Charles Best Doctoral Award from the Canadian Institutes of Health Research. H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, Faculty of Health Sciences, and Bone and Joint Institute, Western University; D. Arsenault, MSc, London Health Sciences Centre, University Hospital; B.A. Lanting, MD, Bone and Joint Institute, and Department of Surgery, Schulich School of Medicine and Dentistry, Western University, and London Health Sciences Centre, University Hospital; Y. Zhu, PhD, Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, Western University; C.T. Appleton, MD, PhD, Bone and Joint Institute, and Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, Ontario, Canada. CTA is a consultant for AbbVie, Amgen, BMS, Celgene, Fresenius Kabi, Gilead, Janssen, Merck, Novartis, Pfizer, Hoffmann-La Roche, Sandoz, Sanofi Genzyme, and UCB. BAL is a consultant and receives institutional support from Stryker, DePuy, Smith & Nephew, and Zimmer; and is a principal investigator with research grants from Stryker, DePuy, and Smith & Nephew. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. C.T. Appleton, St. Joseph's Health Care Rheumatology Centre, 268 Grosvenor St., London, ON N6A 4V2, Canada. Email: tom.appleton@sjhc.london.on.ca. Accepted for publication August 3, 2021.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Synovitis Is Associated With Constant Pain in Knee Osteoarthritis: A Cross-sectional Study of OMERACT Knee Ultrasound Scores
Holly T. Philpott, Trevor B. Birmingham, Ryan Pinto, Codie A. Primeau, Dominique Arsenault, Brent A. Lanting, Yayuan Zhu, C. Thomas Appleton
The Journal of Rheumatology Aug 2021, jrheum.210285; DOI: 10.3899/jrheum.210285
Synovitis Is Associated With Constant Pain in Knee Osteoarthritis: A Cross-sectional Study of OMERACT Knee Ultrasound Scores
Holly T. Philpott, Trevor B. Birmingham, Ryan Pinto, Codie A. Primeau, Dominique Arsenault, Brent A. Lanting, Yayuan Zhu, C. Thomas Appleton
The Journal of Rheumatology Aug 2021, jrheum.210285; DOI: 10.3899/jrheum.210285