Research ArticleArticle
Aotearoa New Zealand Māori and Pacific Population-amplified Gout Risk Variants: CLNK Is a Separate Risk Gene at the SLC2A9 Locus
Aichang Ji, Amara Shaukat, Riku Takei, Matthew Bixley, Murray Cadzow, Ruth K. Topless, Tanya J. Major, Amanda Phipps-Green, Marilyn E. Merriman, Jennie Harré Hindmarsh, Lisa K. Stamp, Nicola Dalbeth, Changgui Li and Tony R. Merriman
The Journal of Rheumatology July 2021, jrheum.201684; DOI: https://doi.org/10.3899/jrheum.201684
Aichang Ji
This research was supported by the Health Research Council of New Zealand (Grant 14/527). 1A. Ji, PhD, Research Fellow, C. Li, PhD, Professor, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China; 2A. Shaukat, MSc, Doctoral Student, M. Bixley, MSc, Assistant Research Fellow, M. Cadzow, PhD, Research Fellow, R.K. Topless, BSc, Assistant Research Fellow, T.J. Major, PhD, Research Fellow, A. Phipps-Green, MSc, Assistant Research Fellow, M.E. Merriman, BSc, Research Assistant, Department of Biochemistry, University of Otago, Dunedin, New Zealand; 3R. Takei, MSc, Scientist, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA; 4J. Harré Hindmarsh, PhD, Research Coordinator, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti East Coast, New Zealand; 5L.K. Stamp, PhD, Professor, Department of Medicine, University of Otago, Christchurch, New Zealand; 6N. Dalbeth, MD, Professor, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; 7T.R. Merriman, BSc, Research Assistant, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China, Department of Biochemistry, University of Otago, Dunedin, New Zealand, and Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA. A. Ji and A. Shaukat contributed equally to this work. The authors declare no conflict of interest relevant to this article. Address correspondence to T.R. Merriman, School of Biomedical Sciences, Department of Biochemistry, 710 Cumberland Street, Dunedin, Otago 9054, New Zealand. Email: tony.merriman@otago.ac.nz. Accepted for publication June 11, 2021.
Amara Shaukat
This research was supported by the Health Research Council of New Zealand (Grant 14/527). 1A. Ji, PhD, Research Fellow, C. Li, PhD, Professor, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China; 2A. Shaukat, MSc, Doctoral Student, M. Bixley, MSc, Assistant Research Fellow, M. Cadzow, PhD, Research Fellow, R.K. Topless, BSc, Assistant Research Fellow, T.J. Major, PhD, Research Fellow, A. Phipps-Green, MSc, Assistant Research Fellow, M.E. Merriman, BSc, Research Assistant, Department of Biochemistry, University of Otago, Dunedin, New Zealand; 3R. Takei, MSc, Scientist, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA; 4J. Harré Hindmarsh, PhD, Research Coordinator, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti East Coast, New Zealand; 5L.K. Stamp, PhD, Professor, Department of Medicine, University of Otago, Christchurch, New Zealand; 6N. Dalbeth, MD, Professor, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; 7T.R. Merriman, BSc, Research Assistant, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China, Department of Biochemistry, University of Otago, Dunedin, New Zealand, and Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA. A. Ji and A. Shaukat contributed equally to this work. The authors declare no conflict of interest relevant to this article. Address correspondence to T.R. Merriman, School of Biomedical Sciences, Department of Biochemistry, 710 Cumberland Street, Dunedin, Otago 9054, New Zealand. Email: tony.merriman@otago.ac.nz. Accepted for publication June 11, 2021.
Riku Takei
This research was supported by the Health Research Council of New Zealand (Grant 14/527). 1A. Ji, PhD, Research Fellow, C. Li, PhD, Professor, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China; 2A. Shaukat, MSc, Doctoral Student, M. Bixley, MSc, Assistant Research Fellow, M. Cadzow, PhD, Research Fellow, R.K. Topless, BSc, Assistant Research Fellow, T.J. Major, PhD, Research Fellow, A. Phipps-Green, MSc, Assistant Research Fellow, M.E. Merriman, BSc, Research Assistant, Department of Biochemistry, University of Otago, Dunedin, New Zealand; 3R. Takei, MSc, Scientist, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA; 4J. Harré Hindmarsh, PhD, Research Coordinator, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti East Coast, New Zealand; 5L.K. Stamp, PhD, Professor, Department of Medicine, University of Otago, Christchurch, New Zealand; 6N. Dalbeth, MD, Professor, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; 7T.R. Merriman, BSc, Research Assistant, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China, Department of Biochemistry, University of Otago, Dunedin, New Zealand, and Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA. A. Ji and A. Shaukat contributed equally to this work. The authors declare no conflict of interest relevant to this article. Address correspondence to T.R. Merriman, School of Biomedical Sciences, Department of Biochemistry, 710 Cumberland Street, Dunedin, Otago 9054, New Zealand. Email: tony.merriman@otago.ac.nz. Accepted for publication June 11, 2021.
Matthew Bixley
This research was supported by the Health Research Council of New Zealand (Grant 14/527). 1A. Ji, PhD, Research Fellow, C. Li, PhD, Professor, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China; 2A. Shaukat, MSc, Doctoral Student, M. Bixley, MSc, Assistant Research Fellow, M. Cadzow, PhD, Research Fellow, R.K. Topless, BSc, Assistant Research Fellow, T.J. Major, PhD, Research Fellow, A. Phipps-Green, MSc, Assistant Research Fellow, M.E. Merriman, BSc, Research Assistant, Department of Biochemistry, University of Otago, Dunedin, New Zealand; 3R. Takei, MSc, Scientist, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA; 4J. Harré Hindmarsh, PhD, Research Coordinator, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti East Coast, New Zealand; 5L.K. Stamp, PhD, Professor, Department of Medicine, University of Otago, Christchurch, New Zealand; 6N. Dalbeth, MD, Professor, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; 7T.R. Merriman, BSc, Research Assistant, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China, Department of Biochemistry, University of Otago, Dunedin, New Zealand, and Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA. A. Ji and A. Shaukat contributed equally to this work. The authors declare no conflict of interest relevant to this article. Address correspondence to T.R. Merriman, School of Biomedical Sciences, Department of Biochemistry, 710 Cumberland Street, Dunedin, Otago 9054, New Zealand. Email: tony.merriman@otago.ac.nz. Accepted for publication June 11, 2021.
Murray Cadzow
This research was supported by the Health Research Council of New Zealand (Grant 14/527). 1A. Ji, PhD, Research Fellow, C. Li, PhD, Professor, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China; 2A. Shaukat, MSc, Doctoral Student, M. Bixley, MSc, Assistant Research Fellow, M. Cadzow, PhD, Research Fellow, R.K. Topless, BSc, Assistant Research Fellow, T.J. Major, PhD, Research Fellow, A. Phipps-Green, MSc, Assistant Research Fellow, M.E. Merriman, BSc, Research Assistant, Department of Biochemistry, University of Otago, Dunedin, New Zealand; 3R. Takei, MSc, Scientist, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA; 4J. Harré Hindmarsh, PhD, Research Coordinator, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti East Coast, New Zealand; 5L.K. Stamp, PhD, Professor, Department of Medicine, University of Otago, Christchurch, New Zealand; 6N. Dalbeth, MD, Professor, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; 7T.R. Merriman, BSc, Research Assistant, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China, Department of Biochemistry, University of Otago, Dunedin, New Zealand, and Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA. A. Ji and A. Shaukat contributed equally to this work. The authors declare no conflict of interest relevant to this article. Address correspondence to T.R. Merriman, School of Biomedical Sciences, Department of Biochemistry, 710 Cumberland Street, Dunedin, Otago 9054, New Zealand. Email: tony.merriman@otago.ac.nz. Accepted for publication June 11, 2021.
Ruth K. Topless
This research was supported by the Health Research Council of New Zealand (Grant 14/527). 1A. Ji, PhD, Research Fellow, C. Li, PhD, Professor, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China; 2A. Shaukat, MSc, Doctoral Student, M. Bixley, MSc, Assistant Research Fellow, M. Cadzow, PhD, Research Fellow, R.K. Topless, BSc, Assistant Research Fellow, T.J. Major, PhD, Research Fellow, A. Phipps-Green, MSc, Assistant Research Fellow, M.E. Merriman, BSc, Research Assistant, Department of Biochemistry, University of Otago, Dunedin, New Zealand; 3R. Takei, MSc, Scientist, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA; 4J. Harré Hindmarsh, PhD, Research Coordinator, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti East Coast, New Zealand; 5L.K. Stamp, PhD, Professor, Department of Medicine, University of Otago, Christchurch, New Zealand; 6N. Dalbeth, MD, Professor, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; 7T.R. Merriman, BSc, Research Assistant, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China, Department of Biochemistry, University of Otago, Dunedin, New Zealand, and Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA. A. Ji and A. Shaukat contributed equally to this work. The authors declare no conflict of interest relevant to this article. Address correspondence to T.R. Merriman, School of Biomedical Sciences, Department of Biochemistry, 710 Cumberland Street, Dunedin, Otago 9054, New Zealand. Email: tony.merriman@otago.ac.nz. Accepted for publication June 11, 2021.
Tanya J. Major
This research was supported by the Health Research Council of New Zealand (Grant 14/527). 1A. Ji, PhD, Research Fellow, C. Li, PhD, Professor, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China; 2A. Shaukat, MSc, Doctoral Student, M. Bixley, MSc, Assistant Research Fellow, M. Cadzow, PhD, Research Fellow, R.K. Topless, BSc, Assistant Research Fellow, T.J. Major, PhD, Research Fellow, A. Phipps-Green, MSc, Assistant Research Fellow, M.E. Merriman, BSc, Research Assistant, Department of Biochemistry, University of Otago, Dunedin, New Zealand; 3R. Takei, MSc, Scientist, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA; 4J. Harré Hindmarsh, PhD, Research Coordinator, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti East Coast, New Zealand; 5L.K. Stamp, PhD, Professor, Department of Medicine, University of Otago, Christchurch, New Zealand; 6N. Dalbeth, MD, Professor, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; 7T.R. Merriman, BSc, Research Assistant, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China, Department of Biochemistry, University of Otago, Dunedin, New Zealand, and Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA. A. Ji and A. Shaukat contributed equally to this work. The authors declare no conflict of interest relevant to this article. Address correspondence to T.R. Merriman, School of Biomedical Sciences, Department of Biochemistry, 710 Cumberland Street, Dunedin, Otago 9054, New Zealand. Email: tony.merriman@otago.ac.nz. Accepted for publication June 11, 2021.
Amanda Phipps-Green
This research was supported by the Health Research Council of New Zealand (Grant 14/527). 1A. Ji, PhD, Research Fellow, C. Li, PhD, Professor, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China; 2A. Shaukat, MSc, Doctoral Student, M. Bixley, MSc, Assistant Research Fellow, M. Cadzow, PhD, Research Fellow, R.K. Topless, BSc, Assistant Research Fellow, T.J. Major, PhD, Research Fellow, A. Phipps-Green, MSc, Assistant Research Fellow, M.E. Merriman, BSc, Research Assistant, Department of Biochemistry, University of Otago, Dunedin, New Zealand; 3R. Takei, MSc, Scientist, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA; 4J. Harré Hindmarsh, PhD, Research Coordinator, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti East Coast, New Zealand; 5L.K. Stamp, PhD, Professor, Department of Medicine, University of Otago, Christchurch, New Zealand; 6N. Dalbeth, MD, Professor, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; 7T.R. Merriman, BSc, Research Assistant, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China, Department of Biochemistry, University of Otago, Dunedin, New Zealand, and Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA. A. Ji and A. Shaukat contributed equally to this work. The authors declare no conflict of interest relevant to this article. Address correspondence to T.R. Merriman, School of Biomedical Sciences, Department of Biochemistry, 710 Cumberland Street, Dunedin, Otago 9054, New Zealand. Email: tony.merriman@otago.ac.nz. Accepted for publication June 11, 2021.
Marilyn E. Merriman
This research was supported by the Health Research Council of New Zealand (Grant 14/527). 1A. Ji, PhD, Research Fellow, C. Li, PhD, Professor, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China; 2A. Shaukat, MSc, Doctoral Student, M. Bixley, MSc, Assistant Research Fellow, M. Cadzow, PhD, Research Fellow, R.K. Topless, BSc, Assistant Research Fellow, T.J. Major, PhD, Research Fellow, A. Phipps-Green, MSc, Assistant Research Fellow, M.E. Merriman, BSc, Research Assistant, Department of Biochemistry, University of Otago, Dunedin, New Zealand; 3R. Takei, MSc, Scientist, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA; 4J. Harré Hindmarsh, PhD, Research Coordinator, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti East Coast, New Zealand; 5L.K. Stamp, PhD, Professor, Department of Medicine, University of Otago, Christchurch, New Zealand; 6N. Dalbeth, MD, Professor, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; 7T.R. Merriman, BSc, Research Assistant, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China, Department of Biochemistry, University of Otago, Dunedin, New Zealand, and Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA. A. Ji and A. Shaukat contributed equally to this work. The authors declare no conflict of interest relevant to this article. Address correspondence to T.R. Merriman, School of Biomedical Sciences, Department of Biochemistry, 710 Cumberland Street, Dunedin, Otago 9054, New Zealand. Email: tony.merriman@otago.ac.nz. Accepted for publication June 11, 2021.
Jennie Harré Hindmarsh
This research was supported by the Health Research Council of New Zealand (Grant 14/527). 1A. Ji, PhD, Research Fellow, C. Li, PhD, Professor, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China; 2A. Shaukat, MSc, Doctoral Student, M. Bixley, MSc, Assistant Research Fellow, M. Cadzow, PhD, Research Fellow, R.K. Topless, BSc, Assistant Research Fellow, T.J. Major, PhD, Research Fellow, A. Phipps-Green, MSc, Assistant Research Fellow, M.E. Merriman, BSc, Research Assistant, Department of Biochemistry, University of Otago, Dunedin, New Zealand; 3R. Takei, MSc, Scientist, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA; 4J. Harré Hindmarsh, PhD, Research Coordinator, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti East Coast, New Zealand; 5L.K. Stamp, PhD, Professor, Department of Medicine, University of Otago, Christchurch, New Zealand; 6N. Dalbeth, MD, Professor, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; 7T.R. Merriman, BSc, Research Assistant, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China, Department of Biochemistry, University of Otago, Dunedin, New Zealand, and Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA. A. Ji and A. Shaukat contributed equally to this work. The authors declare no conflict of interest relevant to this article. Address correspondence to T.R. Merriman, School of Biomedical Sciences, Department of Biochemistry, 710 Cumberland Street, Dunedin, Otago 9054, New Zealand. Email: tony.merriman@otago.ac.nz. Accepted for publication June 11, 2021.
Lisa K. Stamp
This research was supported by the Health Research Council of New Zealand (Grant 14/527). 1A. Ji, PhD, Research Fellow, C. Li, PhD, Professor, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China; 2A. Shaukat, MSc, Doctoral Student, M. Bixley, MSc, Assistant Research Fellow, M. Cadzow, PhD, Research Fellow, R.K. Topless, BSc, Assistant Research Fellow, T.J. Major, PhD, Research Fellow, A. Phipps-Green, MSc, Assistant Research Fellow, M.E. Merriman, BSc, Research Assistant, Department of Biochemistry, University of Otago, Dunedin, New Zealand; 3R. Takei, MSc, Scientist, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA; 4J. Harré Hindmarsh, PhD, Research Coordinator, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti East Coast, New Zealand; 5L.K. Stamp, PhD, Professor, Department of Medicine, University of Otago, Christchurch, New Zealand; 6N. Dalbeth, MD, Professor, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; 7T.R. Merriman, BSc, Research Assistant, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China, Department of Biochemistry, University of Otago, Dunedin, New Zealand, and Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA. A. Ji and A. Shaukat contributed equally to this work. The authors declare no conflict of interest relevant to this article. Address correspondence to T.R. Merriman, School of Biomedical Sciences, Department of Biochemistry, 710 Cumberland Street, Dunedin, Otago 9054, New Zealand. Email: tony.merriman@otago.ac.nz. Accepted for publication June 11, 2021.
Nicola Dalbeth
This research was supported by the Health Research Council of New Zealand (Grant 14/527). 1A. Ji, PhD, Research Fellow, C. Li, PhD, Professor, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China; 2A. Shaukat, MSc, Doctoral Student, M. Bixley, MSc, Assistant Research Fellow, M. Cadzow, PhD, Research Fellow, R.K. Topless, BSc, Assistant Research Fellow, T.J. Major, PhD, Research Fellow, A. Phipps-Green, MSc, Assistant Research Fellow, M.E. Merriman, BSc, Research Assistant, Department of Biochemistry, University of Otago, Dunedin, New Zealand; 3R. Takei, MSc, Scientist, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA; 4J. Harré Hindmarsh, PhD, Research Coordinator, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti East Coast, New Zealand; 5L.K. Stamp, PhD, Professor, Department of Medicine, University of Otago, Christchurch, New Zealand; 6N. Dalbeth, MD, Professor, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; 7T.R. Merriman, BSc, Research Assistant, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China, Department of Biochemistry, University of Otago, Dunedin, New Zealand, and Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA. A. Ji and A. Shaukat contributed equally to this work. The authors declare no conflict of interest relevant to this article. Address correspondence to T.R. Merriman, School of Biomedical Sciences, Department of Biochemistry, 710 Cumberland Street, Dunedin, Otago 9054, New Zealand. Email: tony.merriman@otago.ac.nz. Accepted for publication June 11, 2021.
Changgui Li
This research was supported by the Health Research Council of New Zealand (Grant 14/527). 1A. Ji, PhD, Research Fellow, C. Li, PhD, Professor, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China; 2A. Shaukat, MSc, Doctoral Student, M. Bixley, MSc, Assistant Research Fellow, M. Cadzow, PhD, Research Fellow, R.K. Topless, BSc, Assistant Research Fellow, T.J. Major, PhD, Research Fellow, A. Phipps-Green, MSc, Assistant Research Fellow, M.E. Merriman, BSc, Research Assistant, Department of Biochemistry, University of Otago, Dunedin, New Zealand; 3R. Takei, MSc, Scientist, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA; 4J. Harré Hindmarsh, PhD, Research Coordinator, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti East Coast, New Zealand; 5L.K. Stamp, PhD, Professor, Department of Medicine, University of Otago, Christchurch, New Zealand; 6N. Dalbeth, MD, Professor, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; 7T.R. Merriman, BSc, Research Assistant, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China, Department of Biochemistry, University of Otago, Dunedin, New Zealand, and Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA. A. Ji and A. Shaukat contributed equally to this work. The authors declare no conflict of interest relevant to this article. Address correspondence to T.R. Merriman, School of Biomedical Sciences, Department of Biochemistry, 710 Cumberland Street, Dunedin, Otago 9054, New Zealand. Email: tony.merriman@otago.ac.nz. Accepted for publication June 11, 2021.
Tony R. Merriman
This research was supported by the Health Research Council of New Zealand (Grant 14/527). 1A. Ji, PhD, Research Fellow, C. Li, PhD, Professor, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China; 2A. Shaukat, MSc, Doctoral Student, M. Bixley, MSc, Assistant Research Fellow, M. Cadzow, PhD, Research Fellow, R.K. Topless, BSc, Assistant Research Fellow, T.J. Major, PhD, Research Fellow, A. Phipps-Green, MSc, Assistant Research Fellow, M.E. Merriman, BSc, Research Assistant, Department of Biochemistry, University of Otago, Dunedin, New Zealand; 3R. Takei, MSc, Scientist, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA; 4J. Harré Hindmarsh, PhD, Research Coordinator, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti East Coast, New Zealand; 5L.K. Stamp, PhD, Professor, Department of Medicine, University of Otago, Christchurch, New Zealand; 6N. Dalbeth, MD, Professor, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; 7T.R. Merriman, BSc, Research Assistant, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China, Department of Biochemistry, University of Otago, Dunedin, New Zealand, and Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA. A. Ji and A. Shaukat contributed equally to this work. The authors declare no conflict of interest relevant to this article. Address correspondence to T.R. Merriman, School of Biomedical Sciences, Department of Biochemistry, 710 Cumberland Street, Dunedin, Otago 9054, New Zealand. Email: tony.merriman@otago.ac.nz. Accepted for publication June 11, 2021.
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- Published online September 1, 2021.
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- Aichang Ji,
- Amara Shaukat,
- Riku Takei,
- Matthew Bixley,
- Murray Cadzow,
- Ruth K. Topless,
- Tanya J. Major,
- Amanda Phipps-Green,
- Marilyn E. Merriman,
- Jennie Harré Hindmarsh,
- Lisa K. Stamp,
- Nicola Dalbeth,
- Changgui Li and
- Tony R. Merriman
- This research was supported by the Health Research Council of New Zealand (Grant 14/527).
1A. Ji, PhD, Research Fellow, C. Li, PhD, Professor, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China; 2A. Shaukat, MSc, Doctoral Student, M. Bixley, MSc, Assistant Research Fellow, M. Cadzow, PhD, Research Fellow, R.K. Topless, BSc, Assistant Research Fellow, T.J. Major, PhD, Research Fellow, A. Phipps-Green, MSc, Assistant Research Fellow, M.E. Merriman, BSc, Research Assistant, Department of Biochemistry, University of Otago, Dunedin, New Zealand; 3R. Takei, MSc, Scientist, Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA; 4J. Harré Hindmarsh, PhD, Research Coordinator, Ngāti Porou Hauora Charitable Trust, Te Puia Springs, Tairāwhiti East Coast, New Zealand; 5L.K. Stamp, PhD, Professor, Department of Medicine, University of Otago, Christchurch, New Zealand; 6N. Dalbeth, MD, Professor, Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; 7T.R. Merriman, BSc, Research Assistant, Shandong Provincial Key Laboratory of Metabolic Diseases, the Affiliated Hospital of Qingdao University, Qingdao, China, Department of Biochemistry, University of Otago, Dunedin, New Zealand, and Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, USA.
A. Ji and A. Shaukat contributed equally to this work.
The authors declare no conflict of interest relevant to this article. Address correspondence to T.R. Merriman, School of Biomedical Sciences, Department of Biochemistry, 710 Cumberland Street, Dunedin, Otago 9054, New Zealand. Email: tony.merriman@otago.ac.nz.
Accepted for publication June 11, 2021.
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The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Aotearoa New Zealand Māori and Pacific Population-amplified Gout Risk Variants: CLNK Is a Separate Risk Gene at the SLC2A9 Locus
Aichang Ji, Amara Shaukat, Riku Takei, Matthew Bixley, Murray Cadzow, Ruth K. Topless, Tanya J. Major, Amanda Phipps-Green, Marilyn E. Merriman, Jennie Harré Hindmarsh, Lisa K. Stamp, Nicola Dalbeth, Changgui Li, Tony R. Merriman
The Journal of Rheumatology Jul 2021, jrheum.201684; DOI: 10.3899/jrheum.201684
Aotearoa New Zealand Māori and Pacific Population-amplified Gout Risk Variants: CLNK Is a Separate Risk Gene at the SLC2A9 Locus
Aichang Ji, Amara Shaukat, Riku Takei, Matthew Bixley, Murray Cadzow, Ruth K. Topless, Tanya J. Major, Amanda Phipps-Green, Marilyn E. Merriman, Jennie Harré Hindmarsh, Lisa K. Stamp, Nicola Dalbeth, Changgui Li, Tony R. Merriman
The Journal of Rheumatology Jul 2021, jrheum.201684; DOI: 10.3899/jrheum.201684