Research ArticleAccepted Article
Synovitis is associated with constant pain in knee osteoarthritis: a cross-sectional study of OMERACT knee ultrasound scores
Holly T. Philpott, Trevor B. Birmingham, Ryan Pinto, Codie A. Primeau, Dominique Arsenault, Brent Lanting, Yayuan Zhu and C. Thomas Appleton
The Journal of Rheumatology August 2021, jrheum.210285; DOI: https://doi.org/10.3899/jrheum.210285
Holly T. Philpott
This work was financially supported by the Academic Medical Organization of Southwestern Ontario (AMOSO) and Western University's Bone and Joint Institute. HP is supported by a Frederick Banting and Charles Best Doctoral Award from the Canadian Institutes of Health Research (CIHR). H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, Faculty of Health Sciences, University of Western Ontario, London, ON, Canada; H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, B. Lanting, MD, MSc, C.T. Appleton, MD, PhD, Bone and Joint Institute, University of Western Ontario, London, ON, Canada; D. Arsenault, MSc, B. Lanting, MD, MSc, London Health Sciences Centre, University Hospital, London, ON, Canada; B. Lanting, MD, MSc, Department of Surgery, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Y. Zhu, PhD, Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; C.T. Appleton, MD, PhD, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada, on behalf of the WOREO Knee Study group. Conflict of Interest: CTA is a consultant for Abbvie, Amgen, Bristol Myers Squibb, Celgene, Fresenius Kabi, Gilead, Janssen, Merck, Novartis, Pfizer, Hoffman LaRoche, Sandoz, Sanofi- Genzyme, and UCB. BL is a consultant and receives institutional support from Stryker, DePuy, Smith & Nephew, and Zimmer. BL is a principal investigator with research grants from Stryker, DePuy, and Smith & Nephew. Statement of ethics and consent: Participants provided written informed consent and the registry was approved by Western University's Research Ethics Board for Health Sciences Research Involving Human Subjects (HSREB #109255). Corresponding author: Tom Appleton MD PhD FRCPC, SJHC Rheumatology Centre, 268 Grosvenor St., London, ON, Canada, N6A 4V2. Email: tom.appleton@sjhc.london.on.ca
Trevor B. Birmingham
This work was financially supported by the Academic Medical Organization of Southwestern Ontario (AMOSO) and Western University's Bone and Joint Institute. HP is supported by a Frederick Banting and Charles Best Doctoral Award from the Canadian Institutes of Health Research (CIHR). H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, Faculty of Health Sciences, University of Western Ontario, London, ON, Canada; H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, B. Lanting, MD, MSc, C.T. Appleton, MD, PhD, Bone and Joint Institute, University of Western Ontario, London, ON, Canada; D. Arsenault, MSc, B. Lanting, MD, MSc, London Health Sciences Centre, University Hospital, London, ON, Canada; B. Lanting, MD, MSc, Department of Surgery, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Y. Zhu, PhD, Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; C.T. Appleton, MD, PhD, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada, on behalf of the WOREO Knee Study group. Conflict of Interest: CTA is a consultant for Abbvie, Amgen, Bristol Myers Squibb, Celgene, Fresenius Kabi, Gilead, Janssen, Merck, Novartis, Pfizer, Hoffman LaRoche, Sandoz, Sanofi- Genzyme, and UCB. BL is a consultant and receives institutional support from Stryker, DePuy, Smith & Nephew, and Zimmer. BL is a principal investigator with research grants from Stryker, DePuy, and Smith & Nephew. Statement of ethics and consent: Participants provided written informed consent and the registry was approved by Western University's Research Ethics Board for Health Sciences Research Involving Human Subjects (HSREB #109255). Corresponding author: Tom Appleton MD PhD FRCPC, SJHC Rheumatology Centre, 268 Grosvenor St., London, ON, Canada, N6A 4V2. Email: tom.appleton@sjhc.london.on.ca
Ryan Pinto
This work was financially supported by the Academic Medical Organization of Southwestern Ontario (AMOSO) and Western University's Bone and Joint Institute. HP is supported by a Frederick Banting and Charles Best Doctoral Award from the Canadian Institutes of Health Research (CIHR). H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, Faculty of Health Sciences, University of Western Ontario, London, ON, Canada; H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, B. Lanting, MD, MSc, C.T. Appleton, MD, PhD, Bone and Joint Institute, University of Western Ontario, London, ON, Canada; D. Arsenault, MSc, B. Lanting, MD, MSc, London Health Sciences Centre, University Hospital, London, ON, Canada; B. Lanting, MD, MSc, Department of Surgery, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Y. Zhu, PhD, Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; C.T. Appleton, MD, PhD, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada, on behalf of the WOREO Knee Study group. Conflict of Interest: CTA is a consultant for Abbvie, Amgen, Bristol Myers Squibb, Celgene, Fresenius Kabi, Gilead, Janssen, Merck, Novartis, Pfizer, Hoffman LaRoche, Sandoz, Sanofi- Genzyme, and UCB. BL is a consultant and receives institutional support from Stryker, DePuy, Smith & Nephew, and Zimmer. BL is a principal investigator with research grants from Stryker, DePuy, and Smith & Nephew. Statement of ethics and consent: Participants provided written informed consent and the registry was approved by Western University's Research Ethics Board for Health Sciences Research Involving Human Subjects (HSREB #109255). Corresponding author: Tom Appleton MD PhD FRCPC, SJHC Rheumatology Centre, 268 Grosvenor St., London, ON, Canada, N6A 4V2. Email: tom.appleton@sjhc.london.on.ca
Codie A. Primeau
This work was financially supported by the Academic Medical Organization of Southwestern Ontario (AMOSO) and Western University's Bone and Joint Institute. HP is supported by a Frederick Banting and Charles Best Doctoral Award from the Canadian Institutes of Health Research (CIHR). H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, Faculty of Health Sciences, University of Western Ontario, London, ON, Canada; H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, B. Lanting, MD, MSc, C.T. Appleton, MD, PhD, Bone and Joint Institute, University of Western Ontario, London, ON, Canada; D. Arsenault, MSc, B. Lanting, MD, MSc, London Health Sciences Centre, University Hospital, London, ON, Canada; B. Lanting, MD, MSc, Department of Surgery, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Y. Zhu, PhD, Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; C.T. Appleton, MD, PhD, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada, on behalf of the WOREO Knee Study group. Conflict of Interest: CTA is a consultant for Abbvie, Amgen, Bristol Myers Squibb, Celgene, Fresenius Kabi, Gilead, Janssen, Merck, Novartis, Pfizer, Hoffman LaRoche, Sandoz, Sanofi- Genzyme, and UCB. BL is a consultant and receives institutional support from Stryker, DePuy, Smith & Nephew, and Zimmer. BL is a principal investigator with research grants from Stryker, DePuy, and Smith & Nephew. Statement of ethics and consent: Participants provided written informed consent and the registry was approved by Western University's Research Ethics Board for Health Sciences Research Involving Human Subjects (HSREB #109255). Corresponding author: Tom Appleton MD PhD FRCPC, SJHC Rheumatology Centre, 268 Grosvenor St., London, ON, Canada, N6A 4V2. Email: tom.appleton@sjhc.london.on.ca
Dominique Arsenault
This work was financially supported by the Academic Medical Organization of Southwestern Ontario (AMOSO) and Western University's Bone and Joint Institute. HP is supported by a Frederick Banting and Charles Best Doctoral Award from the Canadian Institutes of Health Research (CIHR). H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, Faculty of Health Sciences, University of Western Ontario, London, ON, Canada; H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, B. Lanting, MD, MSc, C.T. Appleton, MD, PhD, Bone and Joint Institute, University of Western Ontario, London, ON, Canada; D. Arsenault, MSc, B. Lanting, MD, MSc, London Health Sciences Centre, University Hospital, London, ON, Canada; B. Lanting, MD, MSc, Department of Surgery, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Y. Zhu, PhD, Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; C.T. Appleton, MD, PhD, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada, on behalf of the WOREO Knee Study group. Conflict of Interest: CTA is a consultant for Abbvie, Amgen, Bristol Myers Squibb, Celgene, Fresenius Kabi, Gilead, Janssen, Merck, Novartis, Pfizer, Hoffman LaRoche, Sandoz, Sanofi- Genzyme, and UCB. BL is a consultant and receives institutional support from Stryker, DePuy, Smith & Nephew, and Zimmer. BL is a principal investigator with research grants from Stryker, DePuy, and Smith & Nephew. Statement of ethics and consent: Participants provided written informed consent and the registry was approved by Western University's Research Ethics Board for Health Sciences Research Involving Human Subjects (HSREB #109255). Corresponding author: Tom Appleton MD PhD FRCPC, SJHC Rheumatology Centre, 268 Grosvenor St., London, ON, Canada, N6A 4V2. Email: tom.appleton@sjhc.london.on.ca
Brent Lanting
This work was financially supported by the Academic Medical Organization of Southwestern Ontario (AMOSO) and Western University's Bone and Joint Institute. HP is supported by a Frederick Banting and Charles Best Doctoral Award from the Canadian Institutes of Health Research (CIHR). H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, Faculty of Health Sciences, University of Western Ontario, London, ON, Canada; H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, B. Lanting, MD, MSc, C.T. Appleton, MD, PhD, Bone and Joint Institute, University of Western Ontario, London, ON, Canada; D. Arsenault, MSc, B. Lanting, MD, MSc, London Health Sciences Centre, University Hospital, London, ON, Canada; B. Lanting, MD, MSc, Department of Surgery, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Y. Zhu, PhD, Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; C.T. Appleton, MD, PhD, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada, on behalf of the WOREO Knee Study group. Conflict of Interest: CTA is a consultant for Abbvie, Amgen, Bristol Myers Squibb, Celgene, Fresenius Kabi, Gilead, Janssen, Merck, Novartis, Pfizer, Hoffman LaRoche, Sandoz, Sanofi- Genzyme, and UCB. BL is a consultant and receives institutional support from Stryker, DePuy, Smith & Nephew, and Zimmer. BL is a principal investigator with research grants from Stryker, DePuy, and Smith & Nephew. Statement of ethics and consent: Participants provided written informed consent and the registry was approved by Western University's Research Ethics Board for Health Sciences Research Involving Human Subjects (HSREB #109255). Corresponding author: Tom Appleton MD PhD FRCPC, SJHC Rheumatology Centre, 268 Grosvenor St., London, ON, Canada, N6A 4V2. Email: tom.appleton@sjhc.london.on.ca
Yayuan Zhu
This work was financially supported by the Academic Medical Organization of Southwestern Ontario (AMOSO) and Western University's Bone and Joint Institute. HP is supported by a Frederick Banting and Charles Best Doctoral Award from the Canadian Institutes of Health Research (CIHR). H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, Faculty of Health Sciences, University of Western Ontario, London, ON, Canada; H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, B. Lanting, MD, MSc, C.T. Appleton, MD, PhD, Bone and Joint Institute, University of Western Ontario, London, ON, Canada; D. Arsenault, MSc, B. Lanting, MD, MSc, London Health Sciences Centre, University Hospital, London, ON, Canada; B. Lanting, MD, MSc, Department of Surgery, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Y. Zhu, PhD, Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; C.T. Appleton, MD, PhD, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada, on behalf of the WOREO Knee Study group. Conflict of Interest: CTA is a consultant for Abbvie, Amgen, Bristol Myers Squibb, Celgene, Fresenius Kabi, Gilead, Janssen, Merck, Novartis, Pfizer, Hoffman LaRoche, Sandoz, Sanofi- Genzyme, and UCB. BL is a consultant and receives institutional support from Stryker, DePuy, Smith & Nephew, and Zimmer. BL is a principal investigator with research grants from Stryker, DePuy, and Smith & Nephew. Statement of ethics and consent: Participants provided written informed consent and the registry was approved by Western University's Research Ethics Board for Health Sciences Research Involving Human Subjects (HSREB #109255). Corresponding author: Tom Appleton MD PhD FRCPC, SJHC Rheumatology Centre, 268 Grosvenor St., London, ON, Canada, N6A 4V2. Email: tom.appleton@sjhc.london.on.ca
C. Thomas Appleton
This work was financially supported by the Academic Medical Organization of Southwestern Ontario (AMOSO) and Western University's Bone and Joint Institute. HP is supported by a Frederick Banting and Charles Best Doctoral Award from the Canadian Institutes of Health Research (CIHR). H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, Faculty of Health Sciences, University of Western Ontario, London, ON, Canada; H.T. Philpott, MSc, T.B. Birmingham, PT, PhD, R. Pinto, MSc, C.A. Primeau, MSc, B. Lanting, MD, MSc, C.T. Appleton, MD, PhD, Bone and Joint Institute, University of Western Ontario, London, ON, Canada; D. Arsenault, MSc, B. Lanting, MD, MSc, London Health Sciences Centre, University Hospital, London, ON, Canada; B. Lanting, MD, MSc, Department of Surgery, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; Y. Zhu, PhD, Department of Epidemiology and Biostatistics, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada; C.T. Appleton, MD, PhD, Department of Medicine, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada, on behalf of the WOREO Knee Study group. Conflict of Interest: CTA is a consultant for Abbvie, Amgen, Bristol Myers Squibb, Celgene, Fresenius Kabi, Gilead, Janssen, Merck, Novartis, Pfizer, Hoffman LaRoche, Sandoz, Sanofi- Genzyme, and UCB. BL is a consultant and receives institutional support from Stryker, DePuy, Smith & Nephew, and Zimmer. BL is a principal investigator with research grants from Stryker, DePuy, and Smith & Nephew. Statement of ethics and consent: Participants provided written informed consent and the registry was approved by Western University's Research Ethics Board for Health Sciences Research Involving Human Subjects (HSREB #109255). Corresponding author: Tom Appleton MD PhD FRCPC, SJHC Rheumatology Centre, 268 Grosvenor St., London, ON, Canada, N6A 4V2. Email: tom.appleton@sjhc.london.on.ca
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The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Accepted manuscript
Synovitis is associated with constant pain in knee osteoarthritis: a cross-sectional study of OMERACT knee ultrasound scores
Holly T. Philpott, Trevor B. Birmingham, Ryan Pinto, Codie A. Primeau, Dominique Arsenault, Brent Lanting, Yayuan Zhu, C. Thomas Appleton
The Journal of Rheumatology Aug 2021, jrheum.210285; DOI: 10.3899/jrheum.210285
Accepted manuscript
Synovitis is associated with constant pain in knee osteoarthritis: a cross-sectional study of OMERACT knee ultrasound scores
Holly T. Philpott, Trevor B. Birmingham, Ryan Pinto, Codie A. Primeau, Dominique Arsenault, Brent Lanting, Yayuan Zhu, C. Thomas Appleton
The Journal of Rheumatology Aug 2021, jrheum.210285; DOI: 10.3899/jrheum.210285