Research ArticleArticle
Effectiveness of a Second Biologic After Failure of a Non–tumor Necrosis Factor Inhibitor As First Biologic in Rheumatoid Arthritis
Katerina Chatzidionysiou, Merete Lund Hetland, Thomas Frisell, Daniela Di Giuseppe, Karin Hellgren, Bente Glintborg, Dan Nordström, Ritva Peltomaa, Kalle Aaltonen, Nina Trokovic, Eirik K. Kristianslund, Tore K. Kvien, Sella A. Provan, Bjorn Gudbjornsson, Gerdur Grondal, Lene Dreyer, Lars Erik Kristensen, Tanja Schjødt Jørgensen, Lennart T.H. Jacobsson and Johan Askling
The Journal of Rheumatology March 2021, jrheum.201467; DOI: https://doi.org/10.3899/jrheum.201467
Katerina Chatzidionysiou
This study was partly funded by grants from Nord-Forsk and FOREUM.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
Merete Lund Hetland
This study was partly funded by grants from Nord-Forsk and FOREUM.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
Thomas Frisell
This study was partly funded by grants from Nord-Forsk and FOREUM.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
Daniela Di Giuseppe
This study was partly funded by grants from Nord-Forsk and FOREUM.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
Karin Hellgren
This study was partly funded by grants from Nord-Forsk and FOREUM.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
Bente Glintborg
This study was partly funded by grants from Nord-Forsk and FOREUM.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
Dan Nordström
This study was partly funded by grants from Nord-Forsk and FOREUM.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
Ritva Peltomaa
This study was partly funded by grants from Nord-Forsk and FOREUM.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
Kalle Aaltonen
This study was partly funded by grants from Nord-Forsk and FOREUM.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
Nina Trokovic
This study was partly funded by grants from Nord-Forsk and FOREUM.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
Eirik K. Kristianslund
This study was partly funded by grants from Nord-Forsk and FOREUM.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
Tore K. Kvien
This study was partly funded by grants from Nord-Forsk and FOREUM.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
Sella A. Provan
This study was partly funded by grants from Nord-Forsk and FOREUM.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
Bjorn Gudbjornsson
This study was partly funded by grants from Nord-Forsk and FOREUM.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
Gerdur Grondal
This study was partly funded by grants from Nord-Forsk and FOREUM.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
Lene Dreyer
This study was partly funded by grants from Nord-Forsk and FOREUM.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
Lars Erik Kristensen
This study was partly funded by grants from Nord-Forsk and FOREUM.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
Tanja Schjødt Jørgensen
This study was partly funded by grants from Nord-Forsk and FOREUM.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
Lennart T.H. Jacobsson
This study was partly funded by grants from Nord-Forsk and FOREUM.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
Johan Askling
This study was partly funded by grants from Nord-Forsk and FOREUM.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se. Accepted for publication February 19, 2021.
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- Katerina Chatzidionysiou,
- Merete Lund Hetland,
- Thomas Frisell,
- Daniela Di Giuseppe,
- Karin Hellgren,
- Bente Glintborg,
- Dan Nordström,
- Ritva Peltomaa,
- Kalle Aaltonen,
- Nina Trokovic,
- Eirik K. Kristianslund,
- Tore K. Kvien,
- Sella A. Provan,
- Bjorn Gudbjornsson,
- Gerdur Grondal,
- Lene Dreyer,
- Lars Erik Kristensen,
- Tanja Schjødt Jørgensen,
- Lennart T.H. Jacobsson and
- Johan Askling
- This study was partly funded by grants from Nord-Forsk and FOREUM.<br> K. Chatzidionysiou, MD, PhD, Associate Professor, T. Frisell, PhD, Associate Professor, D. Di Giuseppe, PhD, K. Hellgren, MD, PhD, J. Askling, MD, PhD, Professor, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; M.L. Hetland, MD, PhD, Professor, B. Glintborg, MD, PhD, Associate Professor, DANBIO and Copenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre of Head and Orthopedics, Rigshospitalet, and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, on behalf of the DANBIO Registry, Copenhagen, Denmark; D. Nordström, MD, PhD, Professor, R. Peltomaa, MD, PhD, N. Trokovic, MS, Helsinki University and Hospital (ROB-FIN), Departments of Medicine and Rheumatology, Helsinki, Finland; K. Aaltonen, MD, PhD, Pharmaceuticals Pricing Board, Ministry of Social Affairs and Health, Helsinki, Finland; E.K. Kristianslund, MD, PhD, T.K. Kvien, MD, PhD, Professor, S.A. Provan, MD, PhD, Professor, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway; B. Gudbjornsson, MD, PhD, Professor, Centre for Rheumatology Research, University Hospital, and Faculty of Medicine, University of Iceland, Reykjavik, Iceland; G. Grondal, MD, PhD, Professor, Department of Rheumatology and Centre for Rheumatology Research, University Hospital, Reykjavik, Iceland; L. Dreyer, MD, PhD, Professor, Department of Rheumatology, Aalborg University Hospital, and Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; L.E. Kristensen, MD, PhD, Professor, T.S. Jørgensen, MD, PhD, The Parker Institute, Copenhagen University Hospital, Bispebjerg and Frederiksberg, Copenhagen, Denmark; L.T. Jacobsson, MD, PhD, Professor, Department of Rheumatology and Inflammation Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
KC has received consultancy fees from Eli Lilly, AbbVie, and Pfizer. MLH has received grant/research support from BMS, MSD, AbbVie, Roche, Novartis, Biogen, and Pfizer; consultancy fees from Eli Lilly; and speaker's fees from Orion Pharma, Biogen, Pfizer, CellTrion, Merck, and Samsung Bioepis. DN has received consultancy fees from AbbVie, BMS, Celgene, MSD, Novartis, Pfizer, Roche, and UCB. BjG has received speaker fees from Novartis. TKK has received consulting fees, speaking fees, and/or honoraria from AbbVie, Amgen, Biogen, BMS, Celtrion, Egis, Eli Lilly, Evapharma, Ewopharma, Janssen, MSD, Mylan, Oktal Pharma, Orion Pharma, Pfizer, Roche, Sandoz, Sanofi, and UCB Pharma. LD has received grant/research support from BMS; consultancy fees from Janssen pharmaceuticals; and speaker's fees from Eli Lilly, UCB, and MSD. LEK has received consulting fees, speaking fees and/or honoraria from AbbVie, Amgen, Biogen, BMS, Eli Lilly, Janssen, Novartis, Pfizer, Sanofi, and UCB Pharma. TSJ has received consulting fees and/or speaking fees from AbbVie, Pfizer, Roche, Novartis, UCB, Biogen, and Eli Lilly. JA (as the principal investigator) and the Karolinska Institutet have entered into agreements with the following companies mainly regarding the safety monitoring of b/tsDMARDs in rheumatology: AbbVie, BMS, MSD, Eli Lilly, Pfizer, Roche, Samsung Bioepis, Sanofi, and UCB. The remaining authors declare no conflicts of interest relevant to this article.
Address correspondence to Dr. K. Chatzidionysiou, Rheumatology Unit, Karolinska University Hospital, D2:00, 171 76, Solna, Stockholm, Sweden. Email: aikaterini.chatzidionysiou@ki.se.
Accepted for publication February 19, 2021.
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In this issue
The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Effectiveness of a Second Biologic After Failure of a Non–tumor Necrosis Factor Inhibitor As First Biologic in Rheumatoid Arthritis
Katerina Chatzidionysiou, Merete Lund Hetland, Thomas Frisell, Daniela Di Giuseppe, Karin Hellgren, Bente Glintborg, Dan Nordström, Ritva Peltomaa, Kalle Aaltonen, Nina Trokovic, Eirik K. Kristianslund, Tore K. Kvien, Sella A. Provan, Bjorn Gudbjornsson, Gerdur Grondal, Lene Dreyer, Lars Erik Kristensen, Tanja Schjødt Jørgensen, Lennart T.H. Jacobsson, Johan Askling
The Journal of Rheumatology Mar 2021, jrheum.201467; DOI: 10.3899/jrheum.201467
Effectiveness of a Second Biologic After Failure of a Non–tumor Necrosis Factor Inhibitor As First Biologic in Rheumatoid Arthritis
Katerina Chatzidionysiou, Merete Lund Hetland, Thomas Frisell, Daniela Di Giuseppe, Karin Hellgren, Bente Glintborg, Dan Nordström, Ritva Peltomaa, Kalle Aaltonen, Nina Trokovic, Eirik K. Kristianslund, Tore K. Kvien, Sella A. Provan, Bjorn Gudbjornsson, Gerdur Grondal, Lene Dreyer, Lars Erik Kristensen, Tanja Schjødt Jørgensen, Lennart T.H. Jacobsson, Johan Askling
The Journal of Rheumatology Mar 2021, jrheum.201467; DOI: 10.3899/jrheum.201467