Research ArticleArticle
Open Access
Predicting Macrophage Activation Syndrome in Childhood-onset Systemic Lupus Erythematosus Patients at Diagnosis
Maya Gerstein, R. Ezequiel Borgia, Daniela Dominguez, Brian M. Feldman, Fangming Liao, Deborah M. Levy, Lawrence Ng, Mohamed Abdelhaleem, Earl D. Silverman and Linda T. Hiraki
The Journal of Rheumatology December 2020, jrheum.200292; DOI: https://doi.org/10.3899/jrheum.200292
Maya Gerstein
LTH is supported by a grant from the Arthritis Society (TAS). M. Gerstein, MD, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada, and Pediatric Rheumatology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; R.E. Borgia, MD, Division of Rheumatology, The Hospital for Sick Children, Toronto, and Department of Pediatrics, College of Medicine, University of Florida, Gainesville, Florida, USA; D. Dominguez, MD, MSc, B.M. Feldman, MD, MSc, FRCPC, F. Liao, MSc, D.M. Levy, MD, MS, FRCPC, L. Ng, BSc, E.D. Silverman, MD, FRCPC, L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario Canada; M. Abdelhaleem, MBBCh, PhD, FRCPC, Division of Haematopathology, The Hospital for Sick Children, Toronto, Ontario, Canada. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. L.T. Hiraki, Clinician Scientist, Division of Rheumatology, Research Institute, The Hospital for Sick Children, PGCRL, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki@sickkids.ca. Open Access Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication November 20, 2020.
R. Ezequiel Borgia
LTH is supported by a grant from the Arthritis Society (TAS). M. Gerstein, MD, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada, and Pediatric Rheumatology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; R.E. Borgia, MD, Division of Rheumatology, The Hospital for Sick Children, Toronto, and Department of Pediatrics, College of Medicine, University of Florida, Gainesville, Florida, USA; D. Dominguez, MD, MSc, B.M. Feldman, MD, MSc, FRCPC, F. Liao, MSc, D.M. Levy, MD, MS, FRCPC, L. Ng, BSc, E.D. Silverman, MD, FRCPC, L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario Canada; M. Abdelhaleem, MBBCh, PhD, FRCPC, Division of Haematopathology, The Hospital for Sick Children, Toronto, Ontario, Canada. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. L.T. Hiraki, Clinician Scientist, Division of Rheumatology, Research Institute, The Hospital for Sick Children, PGCRL, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki@sickkids.ca. Open Access Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication November 20, 2020.
Daniela Dominguez
LTH is supported by a grant from the Arthritis Society (TAS). M. Gerstein, MD, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada, and Pediatric Rheumatology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; R.E. Borgia, MD, Division of Rheumatology, The Hospital for Sick Children, Toronto, and Department of Pediatrics, College of Medicine, University of Florida, Gainesville, Florida, USA; D. Dominguez, MD, MSc, B.M. Feldman, MD, MSc, FRCPC, F. Liao, MSc, D.M. Levy, MD, MS, FRCPC, L. Ng, BSc, E.D. Silverman, MD, FRCPC, L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario Canada; M. Abdelhaleem, MBBCh, PhD, FRCPC, Division of Haematopathology, The Hospital for Sick Children, Toronto, Ontario, Canada. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. L.T. Hiraki, Clinician Scientist, Division of Rheumatology, Research Institute, The Hospital for Sick Children, PGCRL, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki@sickkids.ca. Open Access Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication November 20, 2020.
Brian M. Feldman
LTH is supported by a grant from the Arthritis Society (TAS). M. Gerstein, MD, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada, and Pediatric Rheumatology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; R.E. Borgia, MD, Division of Rheumatology, The Hospital for Sick Children, Toronto, and Department of Pediatrics, College of Medicine, University of Florida, Gainesville, Florida, USA; D. Dominguez, MD, MSc, B.M. Feldman, MD, MSc, FRCPC, F. Liao, MSc, D.M. Levy, MD, MS, FRCPC, L. Ng, BSc, E.D. Silverman, MD, FRCPC, L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario Canada; M. Abdelhaleem, MBBCh, PhD, FRCPC, Division of Haematopathology, The Hospital for Sick Children, Toronto, Ontario, Canada. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. L.T. Hiraki, Clinician Scientist, Division of Rheumatology, Research Institute, The Hospital for Sick Children, PGCRL, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki@sickkids.ca. Open Access Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication November 20, 2020.
Fangming Liao
LTH is supported by a grant from the Arthritis Society (TAS). M. Gerstein, MD, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada, and Pediatric Rheumatology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; R.E. Borgia, MD, Division of Rheumatology, The Hospital for Sick Children, Toronto, and Department of Pediatrics, College of Medicine, University of Florida, Gainesville, Florida, USA; D. Dominguez, MD, MSc, B.M. Feldman, MD, MSc, FRCPC, F. Liao, MSc, D.M. Levy, MD, MS, FRCPC, L. Ng, BSc, E.D. Silverman, MD, FRCPC, L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario Canada; M. Abdelhaleem, MBBCh, PhD, FRCPC, Division of Haematopathology, The Hospital for Sick Children, Toronto, Ontario, Canada. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. L.T. Hiraki, Clinician Scientist, Division of Rheumatology, Research Institute, The Hospital for Sick Children, PGCRL, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki@sickkids.ca. Open Access Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication November 20, 2020.
Deborah M. Levy
LTH is supported by a grant from the Arthritis Society (TAS). M. Gerstein, MD, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada, and Pediatric Rheumatology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; R.E. Borgia, MD, Division of Rheumatology, The Hospital for Sick Children, Toronto, and Department of Pediatrics, College of Medicine, University of Florida, Gainesville, Florida, USA; D. Dominguez, MD, MSc, B.M. Feldman, MD, MSc, FRCPC, F. Liao, MSc, D.M. Levy, MD, MS, FRCPC, L. Ng, BSc, E.D. Silverman, MD, FRCPC, L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario Canada; M. Abdelhaleem, MBBCh, PhD, FRCPC, Division of Haematopathology, The Hospital for Sick Children, Toronto, Ontario, Canada. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. L.T. Hiraki, Clinician Scientist, Division of Rheumatology, Research Institute, The Hospital for Sick Children, PGCRL, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki@sickkids.ca. Open Access Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication November 20, 2020.
Lawrence Ng
LTH is supported by a grant from the Arthritis Society (TAS). M. Gerstein, MD, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada, and Pediatric Rheumatology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; R.E. Borgia, MD, Division of Rheumatology, The Hospital for Sick Children, Toronto, and Department of Pediatrics, College of Medicine, University of Florida, Gainesville, Florida, USA; D. Dominguez, MD, MSc, B.M. Feldman, MD, MSc, FRCPC, F. Liao, MSc, D.M. Levy, MD, MS, FRCPC, L. Ng, BSc, E.D. Silverman, MD, FRCPC, L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario Canada; M. Abdelhaleem, MBBCh, PhD, FRCPC, Division of Haematopathology, The Hospital for Sick Children, Toronto, Ontario, Canada. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. L.T. Hiraki, Clinician Scientist, Division of Rheumatology, Research Institute, The Hospital for Sick Children, PGCRL, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki@sickkids.ca. Open Access Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication November 20, 2020.
Mohamed Abdelhaleem
LTH is supported by a grant from the Arthritis Society (TAS). M. Gerstein, MD, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada, and Pediatric Rheumatology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; R.E. Borgia, MD, Division of Rheumatology, The Hospital for Sick Children, Toronto, and Department of Pediatrics, College of Medicine, University of Florida, Gainesville, Florida, USA; D. Dominguez, MD, MSc, B.M. Feldman, MD, MSc, FRCPC, F. Liao, MSc, D.M. Levy, MD, MS, FRCPC, L. Ng, BSc, E.D. Silverman, MD, FRCPC, L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario Canada; M. Abdelhaleem, MBBCh, PhD, FRCPC, Division of Haematopathology, The Hospital for Sick Children, Toronto, Ontario, Canada. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. L.T. Hiraki, Clinician Scientist, Division of Rheumatology, Research Institute, The Hospital for Sick Children, PGCRL, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki@sickkids.ca. Open Access Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication November 20, 2020.
Earl D. Silverman
LTH is supported by a grant from the Arthritis Society (TAS). M. Gerstein, MD, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada, and Pediatric Rheumatology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; R.E. Borgia, MD, Division of Rheumatology, The Hospital for Sick Children, Toronto, and Department of Pediatrics, College of Medicine, University of Florida, Gainesville, Florida, USA; D. Dominguez, MD, MSc, B.M. Feldman, MD, MSc, FRCPC, F. Liao, MSc, D.M. Levy, MD, MS, FRCPC, L. Ng, BSc, E.D. Silverman, MD, FRCPC, L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario Canada; M. Abdelhaleem, MBBCh, PhD, FRCPC, Division of Haematopathology, The Hospital for Sick Children, Toronto, Ontario, Canada. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. L.T. Hiraki, Clinician Scientist, Division of Rheumatology, Research Institute, The Hospital for Sick Children, PGCRL, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki@sickkids.ca. Open Access Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication November 20, 2020.
Linda T. Hiraki
LTH is supported by a grant from the Arthritis Society (TAS). M. Gerstein, MD, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada, and Pediatric Rheumatology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel; R.E. Borgia, MD, Division of Rheumatology, The Hospital for Sick Children, Toronto, and Department of Pediatrics, College of Medicine, University of Florida, Gainesville, Florida, USA; D. Dominguez, MD, MSc, B.M. Feldman, MD, MSc, FRCPC, F. Liao, MSc, D.M. Levy, MD, MS, FRCPC, L. Ng, BSc, E.D. Silverman, MD, FRCPC, L.T. Hiraki, MD, FRCPC, ScD, Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario Canada; M. Abdelhaleem, MBBCh, PhD, FRCPC, Division of Haematopathology, The Hospital for Sick Children, Toronto, Ontario, Canada. The authors declare no conflicts of interest relevant to this article. Address correspondence to Dr. L.T. Hiraki, Clinician Scientist, Division of Rheumatology, Research Institute, The Hospital for Sick Children, PGCRL, 686 Bay Street, Toronto, ON M5G 0A4, Canada. Email: linda.hiraki@sickkids.ca. Open Access Article. For details see Reprints and Permissions at jrheum.org. Accepted for publication November 20, 2020.
In this issue
The Journal of Rheumatology
Vol. 51, Issue 3
1 Mar 2024
Predicting Macrophage Activation Syndrome in Childhood-onset Systemic Lupus Erythematosus Patients at Diagnosis
Maya Gerstein, R. Ezequiel Borgia, Daniela Dominguez, Brian M. Feldman, Fangming Liao, Deborah M. Levy, Lawrence Ng, Mohamed Abdelhaleem, Earl D. Silverman, Linda T. Hiraki
The Journal of Rheumatology Dec 2020, jrheum.200292; DOI: 10.3899/jrheum.200292
Predicting Macrophage Activation Syndrome in Childhood-onset Systemic Lupus Erythematosus Patients at Diagnosis
Maya Gerstein, R. Ezequiel Borgia, Daniela Dominguez, Brian M. Feldman, Fangming Liao, Deborah M. Levy, Lawrence Ng, Mohamed Abdelhaleem, Earl D. Silverman, Linda T. Hiraki
The Journal of Rheumatology Dec 2020, jrheum.200292; DOI: 10.3899/jrheum.200292