Abstract
Rheumatoid nodule1, one of the most characteristic manifestations of rheumatoid arthritis (RA), occurs in approximately 30% of patients, is generally associated with positive rheumatoid factor, smoking, and high disease activity2, and occurs in some patients with specific genotypes receiving methotrexate (MTX)3. An 83-year-old woman with a history of anticitrullinated protein antibody–positive RA treated by oral MTX, as well as gout, was hospitalized for a growing tumor of her right forearm.