Research ArticleAccepted Article
Predicting Response to Tocilizumab Monotherapy in Rheumatoid Arthritis: A Real-World Data Analysis Using Machine Learning
Fredrik D. Johansson, Jamie E. Collins, Vincent Yau, Hongshu Guan, Seoyoung C. Kim, Elena Losina, David Sontag, Jacklyn Stratton, Huong Trinh, Jeffrey Greenberg and Daniel H. Solomon
The Journal of Rheumatology May 2021, jrheum.201626; DOI: https://doi.org/10.3899/jrheum.201626
Fredrik D. Johansson
Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden; Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston MA; Genentech, South San Francisco, CA; Division of Rheumatology, Brigham and Women’s Hospital, Boston MA; Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston MA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge MA; NYU School of Medicine, New York, NY; Corrona, Waltham MA. This work was supported by a research grant from Roche/Genentech to Brigham and Women’s Hospital. DHS receives salary support from research grants to Brigham and Women’s Hospital from Abbvie, Amgen, Corrona, Janssen, Pfizer, and Roche/Genentech. He also serves on the editorial board of Arthritis & Rheumatology and on the FDA Arthritis Advisory Committee. FDJ receives salary support from research grants to Chalmers University of Technology from AstraZeneca. SCK received research grants to Brigham and Women’s Hospital from AbbVie, Pfizer, Roche, and Bristol-Myers Squibb for unrelated studies. JEC is a consultant to Boston Imaging Core Labs and serves as Associate Editor for Statistics at Osteoarthritis and Cartilage. Address correspondence to Fredrik D Johansson, Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden. E-mail: fredrik.johansson@chalmers.se.
Jamie E. Collins
Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden; Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston MA; Genentech, South San Francisco, CA; Division of Rheumatology, Brigham and Women’s Hospital, Boston MA; Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston MA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge MA; NYU School of Medicine, New York, NY; Corrona, Waltham MA. This work was supported by a research grant from Roche/Genentech to Brigham and Women’s Hospital. DHS receives salary support from research grants to Brigham and Women’s Hospital from Abbvie, Amgen, Corrona, Janssen, Pfizer, and Roche/Genentech. He also serves on the editorial board of Arthritis & Rheumatology and on the FDA Arthritis Advisory Committee. FDJ receives salary support from research grants to Chalmers University of Technology from AstraZeneca. SCK received research grants to Brigham and Women’s Hospital from AbbVie, Pfizer, Roche, and Bristol-Myers Squibb for unrelated studies. JEC is a consultant to Boston Imaging Core Labs and serves as Associate Editor for Statistics at Osteoarthritis and Cartilage. Address correspondence to Fredrik D Johansson, Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden. E-mail: fredrik.johansson@chalmers.se.
Vincent Yau
Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden; Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston MA; Genentech, South San Francisco, CA; Division of Rheumatology, Brigham and Women’s Hospital, Boston MA; Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston MA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge MA; NYU School of Medicine, New York, NY; Corrona, Waltham MA. This work was supported by a research grant from Roche/Genentech to Brigham and Women’s Hospital. DHS receives salary support from research grants to Brigham and Women’s Hospital from Abbvie, Amgen, Corrona, Janssen, Pfizer, and Roche/Genentech. He also serves on the editorial board of Arthritis & Rheumatology and on the FDA Arthritis Advisory Committee. FDJ receives salary support from research grants to Chalmers University of Technology from AstraZeneca. SCK received research grants to Brigham and Women’s Hospital from AbbVie, Pfizer, Roche, and Bristol-Myers Squibb for unrelated studies. JEC is a consultant to Boston Imaging Core Labs and serves as Associate Editor for Statistics at Osteoarthritis and Cartilage. Address correspondence to Fredrik D Johansson, Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden. E-mail: fredrik.johansson@chalmers.se.
Hongshu Guan
Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden; Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston MA; Genentech, South San Francisco, CA; Division of Rheumatology, Brigham and Women’s Hospital, Boston MA; Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston MA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge MA; NYU School of Medicine, New York, NY; Corrona, Waltham MA. This work was supported by a research grant from Roche/Genentech to Brigham and Women’s Hospital. DHS receives salary support from research grants to Brigham and Women’s Hospital from Abbvie, Amgen, Corrona, Janssen, Pfizer, and Roche/Genentech. He also serves on the editorial board of Arthritis & Rheumatology and on the FDA Arthritis Advisory Committee. FDJ receives salary support from research grants to Chalmers University of Technology from AstraZeneca. SCK received research grants to Brigham and Women’s Hospital from AbbVie, Pfizer, Roche, and Bristol-Myers Squibb for unrelated studies. JEC is a consultant to Boston Imaging Core Labs and serves as Associate Editor for Statistics at Osteoarthritis and Cartilage. Address correspondence to Fredrik D Johansson, Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden. E-mail: fredrik.johansson@chalmers.se.
Seoyoung C. Kim
Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden; Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston MA; Genentech, South San Francisco, CA; Division of Rheumatology, Brigham and Women’s Hospital, Boston MA; Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston MA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge MA; NYU School of Medicine, New York, NY; Corrona, Waltham MA. This work was supported by a research grant from Roche/Genentech to Brigham and Women’s Hospital. DHS receives salary support from research grants to Brigham and Women’s Hospital from Abbvie, Amgen, Corrona, Janssen, Pfizer, and Roche/Genentech. He also serves on the editorial board of Arthritis & Rheumatology and on the FDA Arthritis Advisory Committee. FDJ receives salary support from research grants to Chalmers University of Technology from AstraZeneca. SCK received research grants to Brigham and Women’s Hospital from AbbVie, Pfizer, Roche, and Bristol-Myers Squibb for unrelated studies. JEC is a consultant to Boston Imaging Core Labs and serves as Associate Editor for Statistics at Osteoarthritis and Cartilage. Address correspondence to Fredrik D Johansson, Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden. E-mail: fredrik.johansson@chalmers.se.
Elena Losina
Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden; Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston MA; Genentech, South San Francisco, CA; Division of Rheumatology, Brigham and Women’s Hospital, Boston MA; Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston MA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge MA; NYU School of Medicine, New York, NY; Corrona, Waltham MA. This work was supported by a research grant from Roche/Genentech to Brigham and Women’s Hospital. DHS receives salary support from research grants to Brigham and Women’s Hospital from Abbvie, Amgen, Corrona, Janssen, Pfizer, and Roche/Genentech. He also serves on the editorial board of Arthritis & Rheumatology and on the FDA Arthritis Advisory Committee. FDJ receives salary support from research grants to Chalmers University of Technology from AstraZeneca. SCK received research grants to Brigham and Women’s Hospital from AbbVie, Pfizer, Roche, and Bristol-Myers Squibb for unrelated studies. JEC is a consultant to Boston Imaging Core Labs and serves as Associate Editor for Statistics at Osteoarthritis and Cartilage. Address correspondence to Fredrik D Johansson, Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden. E-mail: fredrik.johansson@chalmers.se.
David Sontag
Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden; Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston MA; Genentech, South San Francisco, CA; Division of Rheumatology, Brigham and Women’s Hospital, Boston MA; Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston MA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge MA; NYU School of Medicine, New York, NY; Corrona, Waltham MA. This work was supported by a research grant from Roche/Genentech to Brigham and Women’s Hospital. DHS receives salary support from research grants to Brigham and Women’s Hospital from Abbvie, Amgen, Corrona, Janssen, Pfizer, and Roche/Genentech. He also serves on the editorial board of Arthritis & Rheumatology and on the FDA Arthritis Advisory Committee. FDJ receives salary support from research grants to Chalmers University of Technology from AstraZeneca. SCK received research grants to Brigham and Women’s Hospital from AbbVie, Pfizer, Roche, and Bristol-Myers Squibb for unrelated studies. JEC is a consultant to Boston Imaging Core Labs and serves as Associate Editor for Statistics at Osteoarthritis and Cartilage. Address correspondence to Fredrik D Johansson, Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden. E-mail: fredrik.johansson@chalmers.se.
Jacklyn Stratton
Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden; Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston MA; Genentech, South San Francisco, CA; Division of Rheumatology, Brigham and Women’s Hospital, Boston MA; Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston MA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge MA; NYU School of Medicine, New York, NY; Corrona, Waltham MA. This work was supported by a research grant from Roche/Genentech to Brigham and Women’s Hospital. DHS receives salary support from research grants to Brigham and Women’s Hospital from Abbvie, Amgen, Corrona, Janssen, Pfizer, and Roche/Genentech. He also serves on the editorial board of Arthritis & Rheumatology and on the FDA Arthritis Advisory Committee. FDJ receives salary support from research grants to Chalmers University of Technology from AstraZeneca. SCK received research grants to Brigham and Women’s Hospital from AbbVie, Pfizer, Roche, and Bristol-Myers Squibb for unrelated studies. JEC is a consultant to Boston Imaging Core Labs and serves as Associate Editor for Statistics at Osteoarthritis and Cartilage. Address correspondence to Fredrik D Johansson, Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden. E-mail: fredrik.johansson@chalmers.se.
Huong Trinh
Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden; Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston MA; Genentech, South San Francisco, CA; Division of Rheumatology, Brigham and Women’s Hospital, Boston MA; Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston MA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge MA; NYU School of Medicine, New York, NY; Corrona, Waltham MA. This work was supported by a research grant from Roche/Genentech to Brigham and Women’s Hospital. DHS receives salary support from research grants to Brigham and Women’s Hospital from Abbvie, Amgen, Corrona, Janssen, Pfizer, and Roche/Genentech. He also serves on the editorial board of Arthritis & Rheumatology and on the FDA Arthritis Advisory Committee. FDJ receives salary support from research grants to Chalmers University of Technology from AstraZeneca. SCK received research grants to Brigham and Women’s Hospital from AbbVie, Pfizer, Roche, and Bristol-Myers Squibb for unrelated studies. JEC is a consultant to Boston Imaging Core Labs and serves as Associate Editor for Statistics at Osteoarthritis and Cartilage. Address correspondence to Fredrik D Johansson, Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden. E-mail: fredrik.johansson@chalmers.se.
Jeffrey Greenberg
Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden; Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston MA; Genentech, South San Francisco, CA; Division of Rheumatology, Brigham and Women’s Hospital, Boston MA; Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston MA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge MA; NYU School of Medicine, New York, NY; Corrona, Waltham MA. This work was supported by a research grant from Roche/Genentech to Brigham and Women’s Hospital. DHS receives salary support from research grants to Brigham and Women’s Hospital from Abbvie, Amgen, Corrona, Janssen, Pfizer, and Roche/Genentech. He also serves on the editorial board of Arthritis & Rheumatology and on the FDA Arthritis Advisory Committee. FDJ receives salary support from research grants to Chalmers University of Technology from AstraZeneca. SCK received research grants to Brigham and Women’s Hospital from AbbVie, Pfizer, Roche, and Bristol-Myers Squibb for unrelated studies. JEC is a consultant to Boston Imaging Core Labs and serves as Associate Editor for Statistics at Osteoarthritis and Cartilage. Address correspondence to Fredrik D Johansson, Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden. E-mail: fredrik.johansson@chalmers.se.
Daniel H. Solomon
Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden; Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston MA; Genentech, South San Francisco, CA; Division of Rheumatology, Brigham and Women’s Hospital, Boston MA; Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston MA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge MA; NYU School of Medicine, New York, NY; Corrona, Waltham MA. This work was supported by a research grant from Roche/Genentech to Brigham and Women’s Hospital. DHS receives salary support from research grants to Brigham and Women’s Hospital from Abbvie, Amgen, Corrona, Janssen, Pfizer, and Roche/Genentech. He also serves on the editorial board of Arthritis & Rheumatology and on the FDA Arthritis Advisory Committee. FDJ receives salary support from research grants to Chalmers University of Technology from AstraZeneca. SCK received research grants to Brigham and Women’s Hospital from AbbVie, Pfizer, Roche, and Bristol-Myers Squibb for unrelated studies. JEC is a consultant to Boston Imaging Core Labs and serves as Associate Editor for Statistics at Osteoarthritis and Cartilage. Address correspondence to Fredrik D Johansson, Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden. E-mail: fredrik.johansson@chalmers.se.
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- Published online May 1, 2021.
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© 2021 The Journal of Rheumatology
Author Information
- Fredrik D. Johansson,
- Jamie E. Collins,
- Vincent Yau,
- Hongshu Guan,
- Seoyoung C. Kim,
- Elena Losina,
- David Sontag,
- Jacklyn Stratton,
- Huong Trinh,
- Jeffrey Greenberg and
- Daniel H. Solomon
-
Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden; Department of Orthopedic Surgery, Brigham and Women’s Hospital, Boston MA; Genentech, South San Francisco, CA; Division of Rheumatology, Brigham and Women’s Hospital, Boston MA; Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women’s Hospital, Boston MA; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge MA; NYU School of Medicine, New York, NY; Corrona, Waltham MA.
This work was supported by a research grant from Roche/Genentech to Brigham and Women’s Hospital.
DHS receives salary support from research grants to Brigham and Women’s Hospital from Abbvie, Amgen, Corrona, Janssen, Pfizer, and Roche/Genentech. He also serves on the editorial board of Arthritis & Rheumatology and on the FDA Arthritis Advisory Committee. FDJ receives salary support from research grants to Chalmers University of Technology from AstraZeneca. SCK received research grants to Brigham and Women’s Hospital from AbbVie, Pfizer, Roche, and Bristol-Myers Squibb for unrelated studies. JEC is a consultant to Boston Imaging Core Labs and serves as Associate Editor for Statistics at Osteoarthritis and Cartilage.
Address correspondence to Fredrik D Johansson, Department of Computer Science and Engineering, Chalmers University of Technology, Göteborg, Sweden. E-mail: fredrik.johansson@chalmers.se.
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The Journal of Rheumatology
Vol. 51, Issue 4
1 Apr 2024
Accepted manuscript
Predicting Response to Tocilizumab Monotherapy in Rheumatoid Arthritis: A Real-World Data Analysis Using Machine Learning
Fredrik D. Johansson, Jamie E. Collins, Vincent Yau, Hongshu Guan, Seoyoung C. Kim, Elena Losina, David Sontag, Jacklyn Stratton, Huong Trinh, Jeffrey Greenberg, Daniel H. Solomon
The Journal of Rheumatology May 2021, jrheum.201626; DOI: 10.3899/jrheum.201626
Accepted manuscript
Predicting Response to Tocilizumab Monotherapy in Rheumatoid Arthritis: A Real-World Data Analysis Using Machine Learning
Fredrik D. Johansson, Jamie E. Collins, Vincent Yau, Hongshu Guan, Seoyoung C. Kim, Elena Losina, David Sontag, Jacklyn Stratton, Huong Trinh, Jeffrey Greenberg, Daniel H. Solomon
The Journal of Rheumatology May 2021, jrheum.201626; DOI: 10.3899/jrheum.201626